Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

Novel Synthetic Biscoumarins Target Tumor Necrosis Factor-α in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Hosadurga Kumar Keerthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines

(2014) Hosadurga K. Keerthy et al.   PLoS One

Artemin Reduces Sensitivity to Doxorubicin and Paclitaxel in Endometrial Carcinoma Cells through Specific Regulation of CD24

(2014) Vijay Pandey et al.   Translational Oncology

Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma

(2013) F. Li et al.   Cancer Prevention Research

Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons

(2013) Sachiko Murase et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Investigational Janus kinase inhibitors

(2013) Constantine S Tam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

In Silico Target Predictions: Defining a Benchmarking Data Set and Comparison of Performance of the Multiclass Naïve Bayes and Parzen-Rosenblatt Window

(2013) Alexios Koutsoukas et al.   Journal of Chemical Information and Modeling

Discovery of 1-Methyl-1H-imidazole Derivatives as Potent Jak2 Inhibitors

(2013) Qibin Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

(2013) Kanjoormana Aryan Manu et al.   PLoS One

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

(2012) Sangkil Nam et al.   Molecular Oncology

Targeting STAT3 in hepatocellular carcinoma: Sorafenib again…

(2011) Olivier Rosmorduc et al.   JOURNAL OF HEPATOLOGY

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

From in silico target prediction to multi-target drug design: Current databases, methods and applications

(2011) Alexios Koutsoukas et al.   Journal of Proteomics

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

(2010) Peramaiyan Rajendran et al.   BRITISH JOURNAL OF PHARMACOLOGY

A small oxazine compound as an anti-tumor agent: A novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α

(2010) Basappa et al.   CANCER LETTERS

Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo

(2010) Peramaiyan Rajendran et al.   CLINICAL CANCER RESEARCH

Future perspectives in hepatocellular carcinoma

(2010) Marcus A. Wörns et al.   DIGESTIVE AND LIVER DISEASE

Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor

(2010) Alfonso Quintás-Cardama et al.   INVESTIGATIONAL NEW DRUGS

Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses

(2009) Lawrence J. Wilson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Interleukin-6 Mediates G0/G1 Growth Arrest in Hepatocellular Carcinoma Through a STAT 3-Dependent Pathway

(2007) Dairmuid M. Moran et al.   JOURNAL OF SURGICAL RESEARCH