The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy

Identification of novel regulators of STAT3 activity

(2020) Elina Parri et al.   PLoS One

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

(2020) Grégory La Sala et al.   Nature Communications

Targeting STAT3 in Cancer with Nucleotide Therapeutics

(2019) Yue-Ting K. Lau et al.   Cancers

Resveratrol Downregulates STAT3 Expression and Astrocyte Activation in Primary Astrocyte Cultures of Rat

(2019) Moli Wu et al.   NEUROCHEMICAL RESEARCH

Stat3-mediated alterations in lysosomal membrane protein composition

(2018) Bethan Lloyd-Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells

(2018) Prajna Guha et al.   ONCOGENE

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas

(2018) Yi-Ru Pan et al.   Nature Communications

The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma

(2018) Ying Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MCL-1 inhibition in cancer treatment

(2018) Weiguo Xiang et al.   OncoTargets and Therapy

Strategies and Approaches of Targeting STAT3 for Cancer Treatment

(2016) Steffanie L. Furtek et al.   ACS Chemical Biology

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy

(2015) Joaquim Bosch-Barrera et al.   CANCER TREATMENT REVIEWS

The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3  in Esophageal Squamous Cell Carcinoma

(2015) H.-F. Zhang et al.   CLINICAL CANCER RESEARCH

STAT3 the oncogene - still eluding therapy?

(2015) Matthew S. Wake et al.   FEBS Journal

Phase 1 and pharmacological trial of OPB-31121, a signal transducer and activator of transcription-3 inhibitor, in patients with advanced hepatocellular carcinoma

(2015) Takuji Okusaka et al.   HEPATOLOGY RESEARCH

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

(2015) M Buchert et al.   ONCOGENE

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

(2015) W Huang et al.   ONCOGENE

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

(2015) Beatrice Grabner et al.   Nature Communications

STAT3 regulated ARF expression suppresses prostate cancer metastasis

(2015) Jan Pencik et al.   Nature Communications

A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

(2014) Wei Huang et al.   ACS Chemical Biology

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

(2014) Sutapa Ray et al.   CELLULAR SIGNALLING

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

(2014) U Bharadwaj et al.   ONCOGENE

Therapeutic Targeting of the JAK/STAT Pathway

(2013) Saara Aittomäki et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells

(2013) Lucy Liu et al.   CANCER BIOLOGY & THERAPY

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

Activation of the FGFR-STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation

(2013) L. R. Bohrer et al.   CANCER RESEARCH

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

(2013) X. Zhang et al.   CANCER RESEARCH

HIC1 interacts with and modulates the activity of STAT3

(2013) Ying-Mei Lin et al.   CELL CYCLE

Therapeutic and Preventive Effects of an Epidermal Growth Factor Receptor Inhibitor on Oral Squamous Cell Carcinoma

(2013) H Ge et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model

(2013) Toshi Murakami et al.   LUNG CANCER

The Stat3 paradox: A killer and an oncogene

(2013) Henrike K. Resemann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AZD1480: A Phase I Study of a Novel JAK2 Inhibitor in Solid Tumors

(2013) E. R. Plimack et al.   ONCOLOGIST

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

(2013) Olga A. Timofeeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein–Barr virus-encoded small non-coding RNAs induce cancer cell chemoresistance and migration

(2013) Aditi Sengupta Banerjee et al.   VIROLOGY

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases

(2013) F Hayakawa et al.   Blood Cancer Journal

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

STAT3 can serve as a hit in the process of malignant transformation of primary cells

(2012) M Demaria et al.   CELL DEATH AND DIFFERENTIATION

Plasticity and cross-talk of Interleukin 6-type cytokines

(2012) Christoph Garbers et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Signal Transducer and Activator of Transcription 3 (STAT3) Protein Suppresses Adenoma-to-carcinoma Transition inApcmin/+Mice via Regulation of Snail-1 (SNAI) Protein Stability

(2012) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2012) Bikash Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

(2012) Sangkil Nam et al.   Molecular Oncology

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dormancy Signatures and Metastasis in Estrogen Receptor Positive and Negative Breast Cancer

(2012) Ryung S. Kim et al.   PLoS One

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 negatively regulates thyroid tumorigenesis

(2012) J. P. Couto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alkylation of Cysteine 468 in Stat3 Defines a Novel Site for Therapeutic Development

(2011) Ralf Buettner et al.   ACS Chemical Biology

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

(2011) Steven Fletcher et al.   ChemMedChem

Curcumin

(2011) Mark G. Alexandrow et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells

(2011) Yu Zhang et al.   GASTROENTEROLOGY

Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter

(2011) Mi-Kyung Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

Current Status of Src Inhibitors in Solid Tumor Malignancies

(2011) L. N. Puls et al.   ONCOLOGIST

STAT3 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Matrix Metalloproteinase-7 Expression in Nude Mice

(2011) Hai dong Li et al.   PLoS One

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway

(2010) Y. Dong et al.   CARCINOGENESIS

Nuclear Localization of Signal Transducer and Activator of Transcription 3 in Head and Neck Squamous Cell Carcinoma Is Associated with a Better Prognosis

(2010) E. Pectasides et al.   CLINICAL CANCER RESEARCH

STAT3α Is Oncogenic for Endometrial Carcinoma Cells and Mediates the Oncogenic Effects of Autocrine Human Growth Hormone

(2010) Jian-Zhong Tang et al.   ENDOCRINOLOGY

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

(2010) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL

Inhibition of Ataxia Telangiectasia Mutated Kinase Activity Enhances TRAIL-Mediated Apoptosis in Human Melanoma Cells

(2009) V. N. Ivanov et al.   CANCER RESEARCH

Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression

(2009) J. J. Ranger et al.   CANCER RESEARCH

Up-regulation of C-Terminal Tensin-like Molecule Promotes the Tumorigenicity of Colon Cancer through  -Catenin

(2009) Y.-C. Liao et al.   CANCER RESEARCH

STAT3 Regulation of Glioblastoma Pathogenesis

(2009) Nuria la Iglesia et al.   CURRENT MOLECULAR MEDICINE

Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene

(2009) Isaia Barbieri et al.   MOLECULAR CARCINOGENESIS

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Prognostic Relevance of Tensin4 Expression in Human Gastric Cancer

(2008) Katsuya Sakashita et al.   ANNALS OF SURGICAL ONCOLOGY

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

(2008) D.-S. Shin et al.   CANCER RESEARCH

WP1066, a Novel JAK2 Inhibitor, Suppresses Proliferation and Induces Apoptosis in Erythroid Human Cells Carrying the JAK2 V617F Mutation

(2008) S. Verstovsek et al.   CLINICAL CANCER RESEARCH

Of alphas and betas: distinct and overlapping functions of STAT3 isoforms

(2008) Sarah Dewilde   Frontiers in Bioscience-Landmark

Th17 cells: a new fate for differentiating helper T cells

(2008) Zhi Chen et al.   IMMUNOLOGIC RESEARCH

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer

(2008) Abdulkader Albasri et al.   JOURNAL OF PATHOLOGY

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS