Article
Multidisciplinary Sciences
Qiang Huang, Yu-Jie Shen, Chi-Yao Hsueh, Yi-Fan Zhang, Yang Guo, Xiao-Hui Yuan, Chun-Yan Hu, Jiao-Yu Li, Lei Tao, Hong-Li Gong, Ming Zhang, Liang Zhou
Summary: It was found that CD63 protein is abnormally altered in head and neck squamous cell carcinoma tissue and is linked to prognosis. Overexpression of CD63 inhibits the progression and metastasis of cancer cells, and its interaction with KRT1 helps reduce metastasis.
Article
Oncology
Lingling Li, Piao Li, Wei Zhang, Haiting Zhou, Ergang Guo, Guoqing Hu, Linli Zhang
Summary: In this study, it was found that FERMT1 was upregulated in NPC tissues and correlated with the clinicopathological characteristics of NPC patients. Knockdown of FERMT1 significantly decreased cell proliferation, migration, and invasion by mediating epithelial-mesenchymal transition (EMT) and cell cycle arrest of NPC cells.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Boli Yang, Qiuyu Chen, Changshan Wan, Siyuan Sun, Lanping Zhu, Zhizhong Zhao, Weilong Zhong, Bangmang Wang
Summary: Transgelin is found to be expressed at low levels in ESCC, and its expression is positively correlated with the prognosis of ESCC patients. It inhibits the malignant progression of ESCC by suppressing the occurrence of EMT, as its overexpression significantly reduces cell invasion and proliferation abilities, while its knockdown promotes cell proliferation, migration, and invasion.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qian-Rui Xu, Xiao-Hui Du, Ting-Ting Huang, Yu-Chun Zheng, Yu-Ling Li, Dan-Yi Huang, Hao-Qiang Dai, En-Min Li, Wang-Kai Fang
Summary: Cell-cell junctions play a crucial role in regulating cellular processes and diseases such as cancer. Abnormal expression or localization of cell-cell junction molecules is associated with the progression of esophageal squamous cell carcinoma (ESCC). The study of cell-cell junctions is important for understanding disease mechanisms, diagnosis, and therapeutic developments.
Article
Oncology
Hui Wang, Hong Li, Qingtao Yan, Sumei Gao, Jianfang Gao, Zhenhua Wang, Yi Sun
Summary: Serum MMP-13 levels are significantly higher in patients with cSCC compared to healthy controls, particularly in those with invasive cSCC. Surgical removal of cSCC results in a significant decrease in serum MMP-13 levels. Serum MMP-13 can predict the invasiveness of cSCC and lymph node involvement with high sensitivity and specificity.
Article
Multidisciplinary Sciences
Esther Feng Ying Ng, Atsushi Kaida, Hitomi Nojima, Masahiko Miura
Summary: IGFBP-3 enhances cell migration independently of the cell cycle in TSCC and is associated with the MEK/ERK signaling pathway.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shun Takayama, Yoshihiro Morita, Ayano Nishimoto, Junya Nishimura, Katsuki Takebe, Satoko Kishimoto, Yuka Matsumiya-Matsumoto, Kazuhide Matsunaga, Tomoaki Imai, Narikazu Uzawa
Summary: Oral squamous cell carcinoma (OSCC) is a malignant tumor that can affect oral function and quality of life, and is associated with lymph node metastasis. This study found that GATA6 and ANXA10 may play important roles in regulating EMT and lymph node metastasis in OSCC cells. Inhibition of GATA6 and ANXA10 may promote EMT and increase lymph node metastasis, while overexpression of GATA6 can inhibit EMT and reduce lymph node metastasis.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Food Science & Technology
Ji Feng, Yin Xu, Zhouling Wei, Yiju Xia, Haoxiang Zhang, Caifei Shen, Pu Wang, Wu Yan, Dianchun Fang, Yu Fang
Summary: This study aimed to investigate the effects of capsaicin on invasion and metastasis of esophageal squamous cell carcinoma (ESCC) and the underlying mechanisms. It was found that Cldn3 expression in ESCC was associated with better prognosis. Capsaicin inhibited migration, invasion, and metastasis of ESCC by overexpressing Cldn3 and inhibiting EMT.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Yung-Wei Lin, Yu-Ching Wen, Chi-Hao Hsiao, Feng-Ru Lai, Shun-Fa Yang, Yi-Chieh Yang, Kuo-Hao Ho, Feng-Koo Hsieh, Michael Hsiao, Wei-Jiunn Lee, Ming-Hsien Chien
Summary: SPOCK1 is found to be upregulated in ccRCC tissues and is associated with advanced clinical stages and metastasis. Knockdown and overexpression of SPOCK1 in ccRCC cells affect cell clonogenic ability, migration/invasion ability, and tumor growth and invasion in vitro and in vivo. The mechanism involves the activation of the Snail/Slug-MMP-2 axis to promote EMT and cell motility.
Article
Oncology
Qiuyu Wu, Zhichao Zheng, Junwei Zhang, Zhengguo Piao, Mengyu Xin, Xi Xiang, Antong Wu, Tianyu Zhao, Songkai Huang, Yu Qiao, Jiayu Zhou, Shaofen Xu, Haoyu Cheng, Lihong Wu, Kexiong Ouyang
Summary: This study found that CHRDL1 is downregulated in oral squamous cell carcinoma (OSCC) and its knockdown enhances cell migration, invasion, and adhesion, confirming the inhibitory role of CHRDL1 in OSCC metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Weixuan Wang, Changmei Yang, Haiteng Deng
Summary: This study found that the expression level of the PGDH gene in lung adenocarcinoma tissues was significantly lower than that in pericarcinous tissues. Overexpression of 15-PGDH reduced cell proliferation rate, inhibited the PI3K/AKT/mTOR signaling pathway, down-regulated cell cycle and DNA repair-related proteins, induced G1/S cell cycle arrest, increased susceptibility to cisplatin, and inhibited the EMT process.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Oncology
Zihang Ling, Bin Cheng, Xiaoan Tao
Summary: Oral squamous cell carcinoma (OSCC) is the most common malignancy in global oral cancer, with a low survival rate due to tumor metastasis and recurrence. Epithelial-to-mesenchymal transition (EMT) plays a key role in tumor metastasis and has attracted significant attention. Further research on the role of EMT in OSCC may provide novel insights for developing strategies to combat this type of cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Nanami Nakamura, Hisako Fujihara, Koji Kawaguchi, Hiroyuki Yamada, Ryoko Nakayama, Masaaki Yasukawa, Yuta Kishi, Yoshiki Hamada, Mitsuko Masutani
Summary: Olaparib inhibits EMT and bone invasion in oral carcinoma, suggesting a new therapeutic strategy for this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Lingju Hong, Mingyuan Chen, Maotuan Huang, Weihong Chen, Xiahenazi Abudukeremu, Feifei She, Yanling Chen
Summary: In this study, FOXA2 expression was found to be downregulated in gallbladder cancer and inversely correlated with tumor metastasis, lymph node metastasis, and poor patient prognosis. FOXA2 inhibits epithelial-mesenchymal transition (EMT) and metastasis of gallbladder cancer cells through positive regulation of serine protein kinase inhibitor B5 (SERPINB5) expression. These findings suggest that FOXA2 may be a potential therapeutic target against gallbladder cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Leonardo Franz, Lorenzo Nicole, Anna Chiara Frigo, Giancarlo Ottaviano, Piergiorgio Gaudioso, Tommaso Saccardo, Francesca Visconti, Rocco Cappellesso, Stella Blandamura, Ambrogio Fassina, Gino Marioni
Summary: The mechanism of epithelial-mesenchymal transition (EMT) plays a crucial role in cancer development, tumor progression, and therapy resistance. In laryngeal carcinoma, the predictive value of pN+ status and Slug expression on disease-free survival was identified, supporting the hypothesis of a mutual concurrence of EMT and angiogenesis in driving aggressive phenotype in LSCC. Further studies are needed to characterize the predictive performance of prognostic models based on EMT and angiogenesis.
Article
Medicine, General & Internal
Tae-Oh Kim, Dong-Il Park, Yu Kyeong Han, Keunsoo Kang, Sae-Gwang Park, Hae Ryoun Park, Joo Mi Yi
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Dae-Gun Park, Da Jeong Kim, Bok Hee Woo, Hye Jung Kim, Young Whan Choi, Hae Ryoun Park
ARCHIVES OF ORAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ji Eun Jung, Joo Young Lee, In Ryoung Kim, Sang Mee Park, Ji Wan Kang, Yun Hak Kim, Hae Ryoun Park, Ji Hye Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Mi Ra Yu, Hye Jung Kim, Hae Ryoun Park
Article
Cell Biology
Hyun-Joo Park, Yeon Kim, Mi-Kyoung Kim, Hae-Ryoun Park, Hyung-Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae
Article
Dentistry, Oral Surgery & Medicine
J. H. Rho, H. J. Kim, J. Y. Joo, J. Y. Lee, J. H. Lee, H. R. Park
Summary: Periodontal pathogens play a significant role in the pathogenesis of atherosclerosis, leading to increased lipid accumulation within macrophages and disrupted lipid homeostasis, ultimately contributing to foam cell formation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Eun Jung Kwon, Hyun-Joo Kim, Bok Hee Woo, Ji-Young Joo, Yun Hak Kim, Hae Ryoun Park
Summary: This study aimed to identify differentially expressed exosomal RNAs in healthy subjects and patients with periodontitis, and compare their levels before and after treatment. The results showed that two microRNAs and two small nucleolar RNAs were commonly downregulated during periodontitis and recovered to healthy levels after treatment. These exosomal RNAs could serve as potential biomarkers for periodontitis.
Article
Multidisciplinary Sciences
Hyun-Joo Kim, Youngseuk Cho, Yunhwan Noh, Ji-Young Joo, Hae Ryoun Park
Summary: This study investigated the impact of Non-Communicable Diseases (NCDs) on dental health, with findings showing that individuals with NCDs had significantly higher DMFT scores compared to those without NCDs. Age, NCDs, and psychiatric problems were identified as risk factors for the DMFT score, with Hypertension (HT) being the most influential factor in a newly generated decision tree excluding age.
Article
Biochemistry & Molecular Biology
Yu Kyeong Han, Ha Young Park, Sae-Gwang Park, Jae Joon Hwang, Hae Ryoun Park, Joo Mi Yi
Summary: Growing evidence suggests that genetic and epigenetic factors, including environmental factors, contribute to the development of oral squamous cell carcinoma (OSCC). This study investigated the transcriptional silencing and promoter methylation of CD24, CD44, CD133, and CD147 genes in OSCC cell lines, and found that CD133 and CD147 methylation status is associated with poor survival in OSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ji-Young Joo, Hae Ryoun Park, Youngseuk Cho, Yunhwan Noh, Chang Hun Lee, Seung-Geun Lee
Summary: This study using data from the Korean National Health and Nutrition Examination Survey (KNHANES) found that hypouricemia is associated with an increased risk of periodontitis, while hyperuricemia is not.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eun-Kyung Kim, Hyun-Joo Kim, Ju-Youn Lee, Hae-Ryoun Park, Youngseuk Cho, Yunhwan Noh, Ji-Young Joo
Summary: This study retrospectively analyzed the dental and periodontal status of patients with periodontitis according to the presence of non-communicable diseases (NCDs) and their effects on periodontal treatment outcomes. The findings showed differences in the number of residual teeth and the DMFT index based on the presence of NCDs. The presence of osteoporosis was found to affect the recurrence of periodontitis.
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hyeryeong Kim, Aerin Choi, Mi-Kyung Gong, Hae Ryoun Park, Yong-Il Kim
