Article
Health Care Sciences & Services
Ayse Banu Demir, Domenico Benvenuto, Bilge Karacicek, Yasemin Erac, Silvia Spoto, Silvia Angeletti, Massimo Ciccozzi, Metiner Tosun
Summary: This study investigates the HBV origins of specific microRNAs in liver cancer stem-like cells. The results show that enhanced expression of STIM1 or Orai1 significantly increases the expression of miR3653, and a novel region on the HBV-X protein may affect liver carcinogenesis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Hongjuan You, Dongchen Yuan, Yanwei Bi, Ning Zhang, Qi Li, Tao Tu, Xiao Wei, Qi Lian, Tong Yu, Delong Kong, Xiaoying Yang, Xiangye Liu, Xiaomei Liu, Fanyun Kong, Kuiyang Zheng, Renxian Tang
Summary: The study indicated that vimentin expression is increased in HBX-positive hepatoma cells and HBV-related HCC tissues, correlated with HBX. HBX enhances vimentin expression through LASP1 mediated signal pathways, contributing to EMT, proliferation, and migration of HCC cells.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Anda Huna, Beatrice Nawrocki-Raby, Teresita Padilla-Benavides, Julie Gavard, Sylvie Coscoy, David Bernard, Mathieu Boissan
Summary: NME1, not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis. Loss of NME1 leads to a hybrid phenotype associated with higher metastatic potential, while overexpression of NME1 results in a more epithelial phenotype. Additionally, NME1 inhibits key intracellular signaling pathways involved in inducing EMT, such as AKT and MAPK pathways, and affects the distribution and cell-cell adhesion of E-cadherin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Longxiyu Meng, Jie Gao, Wenjing Mo, Baojun Wang, Hongwei Shen, Wenmin Cao, Meng Ding, Wenli Diao, Wei Chen, Qing Zhang, Jiaxin Shu, Huiqi Dai, Hongqian Guo
Summary: This study reveals that MIOX is a crucial regulatory molecule in ccRCC, which impacts the growth, metastasis, and prognosis of the disease.
Review
Pharmacology & Pharmacy
Po-Chang Shih, Kuo-Ching Mei
Summary: Chemoresistance resulting from cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) leads to inconsistent chemotherapeutic efficacy. The presence of CSCs and EMT allows cancer cells to switch between differentiated and stem-like states, known as cellular plasticity. Phosphorylated signal transducer and activator of transcription 3 (pSTAT3) is increasingly recognized as a major factor in CSCs and EMT, with preclinical studies showing reversal of chemoresistance through STAT3 pathway inhibition. This review focuses on mechanisms involving STAT3 and its target genes in regulating EMT, and also discusses the status of clinical trials using STAT3 pathway inhibitors.
DRUG DISCOVERY TODAY
(2021)
Article
Cell & Tissue Engineering
Siyuan Tian, Xia Zhou, Miao Zhang, Lina Cui, Bo Li, Yansheng Liu, Rui Su, Keshuai Sun, Yinan Hu, Fangfang Yang, Guoyun Xuan, Shuoyi Ma, Xiaohong Zheng, Xinmin Zhou, Changcun Guo, Yulong Shang, Jingbo Wang, Ying Han
Summary: This study found that mesenchymal stem cells (MSCs) protect against liver fibrosis by delivering miR-148a through their secreted exosomes (MSC-EXOs) to regulate intrahepatic macrophage functions. This finding provides a potential therapeutic target for liver fibrosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Mingbo Jia, Ying Wang, Yingxue Guo, Pengyue Yu, Ying Sun, Yanke Song, Liyan Zhao
Summary: Glioblastoma is an aggressive and common intracranial malignant tumor with poor prognosis, and nitidine chloride (NC) may inhibit the epithelial-mesenchymal transition (EMT) process and stem cell-like properties of glioma cells through the JAK2/STAT3 signaling pathway.
Article
Gastroenterology & Hepatology
Beatriz Aguilar-Bravo, Silvia Arino, Delia Blaya, Elisa Pose, Raquel A. Martinez Garcia de la Torre, Maria U. Latasa, Celia Martinez-Sanchez, Laura Zanatto, Laura Sererols-Vinas, Paula Cantallops-Vila, Silvia Affo, Mar Coll, Xavier Thillen, Laurent Dubuquoy, Matias A. Avila, Josepmaria Argemi, Arantza Lamas Paz, Yulia A. Nevzorova, Francisco Javier Cubero, Ramon Bataller, Juan Jose Lozano, Pere Gines, Philippe Mathurin, Pau Sancho-Bru
Summary: This study demonstrates the association of hepatocyte dedifferentiation with disease progression and poor outcome in alcohol-related hepatitis (AH). Hepatobiliary (HB) cells, expressing biliary and hepatocyte markers, are increased in patients with decompensated cirrhosis and AH. The CXCR4 pathway is identified as a new driver of hepatocyte-to-biliary reprogramming and a potential therapeutic target in AH.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Yuheng Zhang, Haozhen Ren, Jun Li, Ruifeng Xue, Hanyi Liu, Zhengyi Zhu, Chenyan Pan, Yunzhen Lin, Anyin Hu, Peng Gou, Jiahui Cai, Jingchao Zhou, Wei Zhu, Xiaolei Shi
Summary: This study reveals that HBV infection plays a crucial role in primary liver cancer development by modulating HBx-induced HMGB1 to promote invasiveness and angiogenesis of tumors, with HMGB1 potentially being a promising target for predicting venous metastasis in liver cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Sei Kuriyama, Gentaro Tanaka, Kurara Takagane, Go Itoh, Masamitsu Tanaka
Summary: In this study, the authors established metastatic cell lines to investigate the mechanisms underlying organ tropism of cancer cells. They identified PEDF as a key factor in kidney metastasis and found that it promotes cancer cell extravasation by increasing vascular permeability and inhibiting EndoMT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Ru Huang, Juan Deng, Chang-Peng Zhu, Shu-Qing Liu, Ya-Lu Cui, Fei Chen, Xin Zhang, Xia Tao, Wei-Fen Xie
Summary: This study aimed to evaluate the therapeutic potential of sulodexide in a mouse model of liver fibrosis and explore its underlying mechanisms. Sulodexide treatment significantly attenuated liver fibrosis induced by thioacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mice. Transcriptome analysis revealed that sulodexide downregulated fibrosis-related genes and liver sinusoidal endothelial cells (LSECs) capillarization-associated genes. Immunohistochemistry confirmed that sulodexide reduced the expression of LSEC capillarization-related genes in fibrotic liver tissues. Scanning electron microscopy showed preserved LSEC fenestrations upon sulodexide treatment. In conclusion, sulodexide attenuated liver fibrosis in mice by restoring differentiated LSECs, suggesting its potential as a therapy for liver fibrosis patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Hongfeng Yuan, Lina Zhao, Ying Yuan, Haolin Yun, Wei Zheng, Yu Geng, Guang Yang, Yufei Wang, Man Zhao, Xiaodong Zhang
Summary: The study shows that HBx attenuates HBV repression by degrading WDR77, leading to enhanced HBV replication in the liver.
Article
Biochemistry & Molecular Biology
Marta Sanchez-Diez, Nicolas Alegria-Aravena, Marta Lopez-Montes, Josefa Quiroz-Troncoso, Raquel Gonzalez-Martos, Adrian Menendez-Rey, Jose Luis Sanchez-Sanchez, Juan Manuel Pastor, Carmen Ramirez-Castillejo
Summary: Protein expression profiles in cancer cells are influenced by cellular factors and can affect their plasticity, transition, and drug resistance. This study examines ten biomarkers related to these features in three colorectal cancer cell lines and investigates their resistance to oxaliplatin. The results show variations in biomarker expression and resistance due to genetic variability. Further research in this area will provide valuable insights into understanding cellular response and preventing drug resistance.
Article
Oncology
Ana Pavlic, Kristian Urh, Katarina Stajer, Emanuela Bostjancic, Nina Zidar
Summary: The study analyzed the expression of the miR-200 family as EMT markers and their target genes in colorectal carcinoma. It found partial EMT at the invasive tumor front and partial MET in metastases based on miR-200 family and its target genes expression.
FRONTIERS IN ONCOLOGY
(2021)