Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mandy Berndt-Paetz, Shanfu Han, Annett Weimann, Annabell Reinhold, Sandra Nuernberger, Jochen Neuhaus
Summary: Three-dimensional tumor models, such as organoids, are valuable tools for bladder cancer research as they accurately mimic the structure and characteristics of solid tumors. These models can be used for functional studies and development of anti-cancer drugs.
Article
Biochemistry & Molecular Biology
Rocio Jimenez-Guerrero, Alejandro Belmonte-Fernandez, M. Luz Flores, Monica Gonzalez-Moreno, Begona Perez-Valderrama, Francisco Romero, Miguel A. Japon, Carmen Saez
Summary: This study reveals the role of the Wnt/β-catenin pathway in paclitaxel resistance in bladder cancer cells with CSC-like properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Pharmacology & Pharmacy
Zhibao Zheng, Na Luan, Kai Tu, Feiyan Liu, Jianwei Wang, Jianguo Sun
Summary: PCDH7 expression in colorectal cancer cells is positively correlated with cell proliferation and drug resistance, while negatively correlated with cell migration and invasion. PCDH7 mediates drug resistance by inhibiting cell apoptosis through upregulating Mcl-1 expression and activating the Wnt signaling pathway. The Mcl-1 inhibitor S63845 can attenuate the anti-apoptotic effect of PCDH7 and sensitizes PCDH7-overexpressing colorectal cancer cells to ABT-263.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Tinghao Li, Hang Tong, Hubin Yin, Yi Luo, Junlong Zhu, Zijia Qin, Siwen Yin, Weiyang He
Summary: The study revealed that starvation-induced autophagy modulates glucose metabolic reprogramming by enhancing Axin1 degradation and beta-catenin nuclear translocation in bladder cancer cells, promoting the transcriptional expression of LDHA and further malignant progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Junhao Zhou, Hu Tian, Xi Zhi, Zhuoyu Xiao, Taoyi Chen, Haoyu Yuan, Qi Chen, Mingkun Chen, Jiankun Yang, Qizhao Zhou, Kangyi Xue, Wenbin Guo, Ming Xia, Jiming Bao, Cheng Yang, Haifeng Duan, Hongyi Wang, Zhipeng Huang, Ting Zhu, Cundong Liu
Summary: The study found that ATF5 is elevated in bladder urothelial cancer tissues, especially in recurrent cases, which is associated with a poor prognosis. Overexpression of ATF5 significantly enhances tumor sphere formation in bladder cancer cells, while silencing ATF5 inhibits this capability. Mechanistically, ATF5 can directly bind to and stimulate the promoter of the DVL I gene, leading to activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Raffaella Soldi, Tithi Ghosh Halder, Samuel Sampson, Hariprasad Vankayalapati, Alexis Weston, Trason Thode, Kapil N. Bhalla, Serina Ng, Ryan Rodriguez Del Villar, Kevin Drenner, Mohan R. Kaadige, Stephen K. Horrigan, Surinder K. Batra, Ravi Salgia, Sunil Sharma
Summary: This study demonstrates that BC-2059 selectively targets the TBL1/beta-catenin protein complex, suggesting its potential as a therapeutic for tumors with deregulated Wnt signaling pathway.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Prem Swaroop Yadav, Shuhao Feng, Qian Cong, Hanjun Kim, Yuchen Liu, Yingzi Yang
Summary: Job syndrome is a rare genetic disorder characterized by immune dysfunction and skeletal developmental abnormalities. Current treatment options are limited, but enhancing Wnt/β-catenin signaling could potentially reduce bone symptoms in patients with Job syndrome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Pengfei Bao, Peng Li, Xiaoqing Zhou, Huijiang Zhang, Shengjie You, Zhaoyu Xu, Qi Wu
Summary: This study aimed to investigate the effects of scaffold matrix attachment region binding protein 1 (SMAR1) on the development of bladder cancer (BCa). The results showed that down-regulation of SMAR1 was associated with worse prognoses in BCa patients. SMAR1 was found to inhibit the viability, proliferation, migration, invasion, and Warburg effect of BCa cells. It is suggested that SMAR1 may suppress the Wnt/beta-catenin signaling pathway to inhibit the progression of BCa.
Article
Oncology
Chenchen Liu, Aiwen Shen, Junquan Song, Lei Cheng, Meng Zhang, Yanong Wang, Xiaowen Liu
Summary: This study identifies a novel Wnt-transactivated lncRNA, CCAT5, which plays a critical role in gastric cancer metastasis. CCAT5 has been shown to promote the growth and metastasis of gastric cancer and accelerate cancer progression through its interaction with the STAT3 signaling pathway. The study also demonstrates that targeting CCAT5 can effectively attenuate the growth and metastasis of Wnt(high) gastric cancer.
CANCER COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li, Lei Ding
Summary: The study demonstrates that Cldn7 deficiency in CRC promotes stemness properties through Sox9-mediated Wnt/beta -catenin signaling. This finding elucidates the inhibitory role of Cldn7 in CRC and reveals a potential molecular mechanism, contributing to further research on Cldn7 and cancer stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biophysics
Shuangkuan Du, Yongjie Sui, Wei Ren, Jiancheng Zhou, Chun Du
Summary: PYCR1 is highly expressed in bladder cancer and may promote cancer progression by affecting the Akt/Wnt/β-catenin signaling pathway. Silencing of PYCR1 shows promising potential as a therapeutic strategy for bladder cancer.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Genetics & Heredity
Amira Awadalla, Hassan Abol-Enein, Eman T. Hamam, Asmaa E. Ahmed, Salma M. Khirallah, Ahmed El-Assmy, Sally Abdallah Mostafa, Ahmed O. Babalghith, Mohamed Ali, Mona Abdel-Rahim, Ahmed A. Shokeir, Ahmed M. Harraz
Summary: This study aims to investigate the role of a set of microRNAs and their target genes in the pathogenesis of bladder cancer. The results showed that the expression levels of let-7a-5P, miR-124-3P, miR-449a-5P, and miR-138-5P decreased while miR-23a-5P increased. Higher expression levels of beta-catenin, FZD4, IRS2, WNT7a, and SOS1 were associated with worse survival, while lower levels of HDAC1, HDAC2, HIF1 alpha, and PTEN were associated with lower survival. These miRNAs and their targeted genes may serve as accurate biomarkers for prognosis in bladder cancer.