Sphingolipid metabolites in inflammatory disease

Adiponectin Inhibits Tumor Necrosis Factor-α–Induced Vascular Inflammatory Response via Caveolin-Mediated Ceramidase Recruitment and Activation

(2014) Yajing Wang et al.   CIRCULATION RESEARCH

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

(2014) Kuzhuvelil B Harikumar et al.   NATURE IMMUNOLOGY

Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

(2014) J. R. Teijaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1–Phosphate, FTY720, and Sphingosine-1–Phosphate Receptors in the Pathobiology of Acute Lung Injury

(2013) Viswanathan Natarajan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M

(2013) Makoto Kurano et al.   ATHEROSCLEROSIS

Co-evolution of sphingomyelin and the ceramide transport protein CERT

(2013) Kentaro Hanada   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

(2013) G. Zhang et al.   BLOOD

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

(2013) D.-H. Nguyen-Tran et al.   Disease Models & Mechanisms

Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice

(2013) Hong Cui et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation

(2013) Mohamad M. Adada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Apolipoprotein M (ApoM) Overexpression Stimulates Formation of Larger ApoM/Sphingosine 1-Phosphate-enriched Plasma High Density Lipoprotein

(2013) Mingxia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages

(2013) Yuquan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression

(2013) Ana Olivera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase

(2013) Jennifer A. Mietla et al.   JOURNAL OF LIPID RESEARCH

Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed I B Kinase Activation

(2013) K. Blackwell et al.   MOLECULAR AND CELLULAR BIOLOGY

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma

(2013) Minal Çalışkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet Activating Factor-Induced Ceramide Micro-Domains Drive Endothelial NOS Activation and Contribute to Barrier Dysfunction

(2013) Sanda Predescu et al.   PLoS One

Editorial Retraction

(2013) P. Puneet et al.   SCIENCE

Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

(2013) T. S. Worgall et al.   Science Translational Medicine

Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization

(2013) M Ali et al.   Cell Death & Disease

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Evidence for a link between histone deacetylation and Ca2+homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts

(2012) Katja Ihlefeld et al.   BIOCHEMICAL JOURNAL

Connecting vesicular transport with lipid synthesis: FAPP2

(2012) Giovanni D'Angelo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

(2012) P Gergely et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingolipid Signaling in Metabolic Disorders

(2012) Timothy Hla et al.   Cell Metabolism

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes

(2012) Joo-Won Park et al.   HEPATOLOGY

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

(2012) Megan M. Price et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis

(2012) Deanna L. Siow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 1α Mediates Ceramide-induced ERM Protein Dephosphorylation

(2012) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress

(2012) Tal I. Arnon et al.   NATURE

Sphingosine Kinase 1 Deficiency Exacerbates LPS-Induced Neuroinflammation

(2012) Natalia M. Grin’kina et al.   PLoS One

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

(2011) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

(2011) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

(2011) Nadia F. Lamour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression

(2011) Jody L. Hankins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

Oral l-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

(2011) Kevin Garofalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis

(2011) Yasuaki Sanada et al.   PLoS One

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood

(2011) T. I. Arnon et al.   SCIENCE

Critical roles for Rac GTPases in T-cell migration to and within lymph nodes

(2010) M. Faroudi et al.   BLOOD

Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model

(2010) Sachi Tsunemi et al.   CLINICAL IMMUNOLOGY

A Novel Function of Sphingosine Kinase 1 Suppression of JNK Activity in Preventing Inflammation and Injury

(2010) Anke Di et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse Macrophage Lipidome

(2010) Edward A. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kruppel-Like Factor 2 Is Required for Trafficking but Not Quiescence in Postactivated T Cells

(2010) K. Takada et al.   JOURNAL OF IMMUNOLOGY

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure

(2010) I. L. Grigorova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model

(2008) Teruaki Nishiuma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

(2008) Ashley J. Snider et al.   FASEB JOURNAL

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY