Hallmarks of aging: An expanding universe

Meta-hallmarks of aging and cancer

(2023) Carlos López-Otín et al.   Cell Metabolism

DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome

(2022) Yosra Bejaoui et al.   AGING CELL

Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice

(2022) Leigh Goedeke et al.   AGING CELL

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

(2022) Peng Xu et al.   Molecular Neurodegeneration

Telomere dysfunction in ageing and age-related diseases

(2022) Francesca Rossiello et al.   NATURE CELL BIOLOGY

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

(2022) João A. Amorim et al.   Nature Reviews Endocrinology

Caloric restriction in humans reveals immunometabolic regulators of health span

(2022) O. Spadaro et al.   SCIENCE

Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis

(2022) Eirini Lionaki et al.   Nature Communications

Noncoding RNAs in age-related cardiovascular diseases

(2022) Amela Jusic et al.   AGEING RESEARCH REVIEWS

Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

(2022) Dafni Chondronasiou et al.   AGING CELL

Biological mechanisms of aging predict age‐related disease co‐occurrence in patients

(2022) Helen C. Fraser et al.   AGING CELL

Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

(2022) Jennifer M. Hafycz et al.   AGING CELL

Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review

(2022) Chris P. Ponting et al.   Annual Review of Genomics and Human Genetics

Acetylation in the regulation of autophagy

(2022) Yinfeng Xu et al.   Autophagy

The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease

(2022) Brage Brakedal et al.   Cell Metabolism

Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

(2022) Shuai Ma et al.   Cell Stem Cell

Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases

(2022) Vidhi Bhatt et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice

(2022) Li Xu et al.   Journal of Genetics and Genomics

Somatic genomic changes in single Alzheimer’s disease neurons

(2022) Michael B. Miller et al.   NATURE

Somatic mutation rates scale with lifespan across mammals

(2022) Alex Cagan et al.   NATURE

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

(2022) Róbert Pálovics et al.   NATURE

Environmental factors shaping the gut microbiome in a Dutch population

(2022) R. Gacesa et al.   NATURE

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

(2022) Zhenqiu Huang et al.   NATURE GENETICS

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

(2022) Karla A. Lee et al.   NATURE MEDICINE

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

(2022) John A. McCulloch et al.   NATURE MEDICINE

The gut microbiome as a modulator of healthy ageing

(2022) Tarini Shankar Ghosh et al.   Nature Reviews Gastroenterology & Hepatology

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

(2022) Patrice D. Cani et al.   Nature Reviews Gastroenterology & Hepatology

Making sense of the ageing methylome

(2022) Kirsten Seale et al.   NATURE REVIEWS GENETICS

Telomere-mediated Lung Disease

(2022) Jonathan K. Alder et al.   PHYSIOLOGICAL REVIEWS

Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues

(2022) Barbara Arbeithuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective role of chaperone-mediated autophagy against atherosclerosis

(2022) Julio Madrigal-Matute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A hypothalamic pathway for Augmentor α–controlled body weight regulation

(2022) Mansoor Ahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

(2022) Victoria Acosta-Rodríguez et al.   SCIENCE

miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing

(2022) Wen-Zhen He et al.   Cell Death & Disease

In vivo partial cellular reprogramming enhances liver plasticity and regeneration

(2022) Tomoaki Hishida et al.   Cell Reports

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

(2022) Diljeet Gill et al.   eLife

Premature aging in mice with error-prone protein synthesis

(2022) Dimitri Shcherbakov et al.   Science Advances

TET2-Driven Clonal Hematopoiesis and Response to Canakinumab

(2022) Eric C. Svensson et al.   JAMA Cardiology

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

(2022) Mahmoud Abdellatif et al.   CIRCULATION

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

(2022) Hanna Lucie Sladitschek-Martens et al.   NATURE

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

(2022) Maurice Michel et al.   SCIENCE

LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes

(2022) Francesco Della Valle et al.   Science Translational Medicine

Diverse partial reprogramming strategies restore youthful gene expression and transiently suppress cell identity

(2022) Antoine E. Roux et al.   Cell Systems

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

(2022) Matthew Simon et al.   EMBO JOURNAL

Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise

(2021) Carolyn Chee et al.   AGING CELL

Telomeres: history, health, and hallmarks of aging

(2021) Deepavali Chakravarti et al.   CELL

In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

(2021) Luke W. Koblan et al.   NATURE

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

(2021) Wei Wang et al.   Science Translational Medicine

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

(2021) Joseph C. Reynolds et al.   Nature Communications

Gut microbiota as the key controllers of “healthy” aging of elderly people

(2021) Emeline Ragonnaud et al.   Immunity & Ageing

Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans

(2021) Paola Sebastiani et al.   AGING CELL

Lonafarnib: First Approval

(2021) Sohita Dhillon   DRUGS

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization

(2021) Ci Ji Lim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Applying genomic and transcriptomic advances to mitochondrial medicine

(2021) William L. Macken et al.   Nature Reviews Neurology

Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol

(2021) Ziqian Shen et al.   AGING CELL

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

Hallmarks of T cell aging

(2021) Maria Mittelbrunn et al.   NATURE IMMUNOLOGY

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

(2021) Mihoko Yoshino et al.   SCIENCE

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

(2021) YongTian Liang et al.   Cell Reports

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

(2021) Yu-Xuan Lu et al.   eLife

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

(2021) Moisés Selman et al.   AGEING RESEARCH REVIEWS

The antagonistic pleiotropy of insulin‐like growth factor 1

(2021) William B. Zhang et al.   AGING CELL

Youthful and age‐related matreotypes predict drugs promoting longevity

(2021) Cyril Statzer et al.   AGING CELL

Type I Interferon signaling controls the accumulation and transcriptomes of monocytes in the aged lung

(2021) Shanti S. D’Souza et al.   AGING CELL

Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?

(2021) Vojo Deretic et al.   Autophagy

Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction

(2021) Chenran Wang et al.   Autophagy

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

(2021) Daniel J. Puleston et al.   CELL

Increased fidelity of protein synthesis extends lifespan

(2021) Victoria Eugenia Martinez-Miguel et al.   Cell Metabolism

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria

(2021) Alvaro González‐Dominguez et al.   EMBO Molecular Medicine

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

(2021) Sujeong Yang et al.   MOLECULAR PSYCHIATRY

The role of retrotransposable elements in ageing and age-associated diseases

(2021) Vera Gorbunova et al.   NATURE

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

(2021) Yuko Sato et al.   NATURE

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

(2021) Yanpu Chen et al.   SCIENCE

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

(2021) M. Grunewald et al.   SCIENCE

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

(2021) Davide D’Amico et al.   TRENDS IN MOLECULAR MEDICINE

Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging

(2021) Thomas A. Rando et al.   Cold Spring Harbor Perspectives in Biology

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

(2021) A. Roichman et al.   Nature Communications

Lactobacillus plantarum GKM3 Promotes Longevity, Memory Retention, and Reduces Brain Oxidation Stress in SAMP8 Mice

(2021) Shih-Wei Lin et al.   Nutrients

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

(2021) Francesco Napoletano et al.   Cell Reports

IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms−

(2021) Qi Wu et al.   Journal for ImmunoTherapy of Cancer

Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator

(2021) Cameron G. McCarthy et al.   JCI Insight

Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan

(2021) Silvana Duran‐Ortiz et al.   AGING CELL

Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis

(2021) Shou‐Zen Fan et al.   AGING CELL

Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

(2021) Oleksandr Demidenko et al.   Aging-US

Molecular Pathology of Laminopathies

(2021) Ji-Yeon Shin et al.   Annual Review of Pathology-Mechanisms of Disease

Cytoplasmic DNA: sources, sensing, and role in aging and disease

(2021) Karl N. Miller et al.   CELL

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

(2021) Giulia Salvadori et al.   Cell Metabolism

The transcription factor code in iPSC reprogramming

(2021) Weixian Deng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Strategies for late phase preclinical and early clinical trials of senolytics

(2021) Erin O. Wissler Gerdes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Circadian autophagy drives iTRF-mediated longevity

(2021) Matt Ulgherait et al.   NATURE

The role of cellular senescence in cardiac disease: basic biology and clinical relevance

(2021) Mozhdeh Mehdizadeh et al.   Nature Reviews Cardiology

Pharmacological targeting of endoplasmic reticulum stress in disease

(2021) Stefan J. Marciniak et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease

(2021) Subodh Kumar et al.   Redox Biology

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

(2021) Alain P. Gobert et al.   GASTROENTEROLOGY

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2020) Samantha M. Solon-Biet et al.   Cell Metabolism

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells

(2020) Kazutaka Murata et al.   Cell Stem Cell

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

(2020) Liam D. Cassidy et al.   Nature Communications

AMPK‐mediated formation of stress granules is required for dietary restriction‐induced longevity in Caenorhabditis elegans

(2020) Chen‐Ting Kuo et al.   AGING CELL

Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

(2020) Melod Mehdipour et al.   Aging-US

Identification of ALK in Thinness

(2020) Michael Orthofer et al.   CELL

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

The ECM path of senescence in aging: components and modifiers

(2020) Naama Levi et al.   FEBS Journal

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

(2020) Satish Sati et al.   MOLECULAR CELL

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Moderation of mitochondrial respiration mitigates metabolic syndrome of aging

(2020) Mojdeh Tavallaie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

(2020) Yonghan He et al.   Nature Communications

Adjusting for age improves identification of gut microbiome alterations in multiple diseases

(2020) Tarini S Ghosh et al.   eLife

Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults

(2020) William B. Zhang et al.   Cells

Wnt signaling pathway in aging-related tissue fibrosis and therapies

(2020) He-He Hu et al.   AGEING RESEARCH REVIEWS

Progress and trends in the development of therapies for Hutchinson–Gilford progeria syndrome

(2020) Wing‐Fu Lai et al.   AGING CELL

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

(2020) Kelvin Yen et al.   Aging-US

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging

(2020) Jan Vijg et al.   CELL

Pathophysiology of premature aging characteristics in Mendelian progeroid disorders

(2020) Raoul C.M. Hennekam   European Journal of Medical Genetics

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila

(2020) Carina Marianne Weigelt et al.   MOLECULAR CELL

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

(2020) Erika Kelmer Sacramento et al.   Molecular Systems Biology

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Classical and Nonclassical Intercellular Communication in Senescence and Ageing

(2020) Juan Antonio Fafián-Labora et al.   TRENDS IN CELL BIOLOGY

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy

(2020) Juliette Humeau et al.   Cell Death & Disease

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

(2020) Takumi Hirata et al.   Nature Communications

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

(2020) Alexander Fedintsev et al.   AGEING RESEARCH REVIEWS

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

(2020) Paul D. Robbins et al.   Annual Review of Pharmacology and Toxicology

ATP-dependent chromatin remodelers in ageing and age-related disorders

(2020) Pynskhem Bok Swer et al.   BIOGERONTOLOGY

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

(2020) José A. Nicolás-Ávila et al.   CELL

A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism

(2020) W. Reid Thompson et al.   GENETICS IN MEDICINE

The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk

(2020) Allan Balmain   NATURE GENETICS

Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats

(2020) Semil Selcen Gocmez et al.   PHYSIOLOGY & BEHAVIOR

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

(2020) Simona Valletta et al.   Nature Communications

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice

(2020) Alberto Rodríguez-Matellán et al.   Stem Cell Reports

Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?

(2020) Jan Frohlich et al.   GeroScience

Effect of rapamycin on aging and age-related diseases—past and future

(2020) Ramasamy Selvarani et al.   GeroScience

Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice

(2020) Clara Sciorati et al.   Aging-US

Hallmarks of Health

(2020) Carlos López-Otín et al.   CELL

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Epigenetic influence of environmentally neurotoxic metals

(2020) Omamuyovwi M. Ijomone et al.   NEUROTOXICOLOGY

Translation elongation rate varies among organs and decreases with age

(2020) Maxim V Gerashchenko et al.   NUCLEIC ACIDS RESEARCH

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

(2020) Huiliang Zhang et al.   eLife

Cell non-autonomous regulation of health and longevity

(2020) Hillary A Miller et al.   eLife

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

(2020) Ghada Alsaleh et al.   eLife

Autophagy-mediated metabolic effects of aspirin

(2020) Francesca Castoldi et al.   Cell Death Discovery

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Transforming medicine with the microbiome

(2019) Niv Zmora et al.   Science Translational Medicine

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome

(2019) Olaya Santiago-Fernández et al.   NATURE MEDICINE

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

The Genetics of Aging: A Vertebrate Perspective

(2019) Param Priya Singh et al.   CELL

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

(2019) Erin Munkácsy et al.   AGING CELL

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

Telomere shortening rate predicts species life span

(2019) Kurt Whittemore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

(2019) Lu Yang et al.   Nature Communications

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

(2019) Marisa Stebegg et al.   Nature Communications

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

(2019) Slaven Stekovic et al.   Cell Metabolism

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

SIRT6, a Mammalian deacylase with multitasking abilities

(2019) Andrew R Chang et al.   PHYSIOLOGICAL REVIEWS

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Mitochondria—Striking a balance between host and endosymbiont

(2019) Richard J. Youle   SCIENCE

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice

(2019) Fabiola Marín‐Aguilar et al.   AGING CELL

Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice

(2019) Dov B. Ballak et al.   AGING CELL

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER

(2019) Robert Thomas Schinzel et al.   CELL

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury

(2019) Monica Chang-Panesso et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

Cellular survival over genomic perfection

(2019) Serena Nik-Zainal et al.   SCIENCE

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

(2019) Leigh Goedeke et al.   Science Translational Medicine

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

(2019) Irene Hernando-Herraez et al.   Nature Communications

Mice with hyper-long telomeres show less metabolic aging and longer lifespans

(2019) Miguel A. Muñoz-Lorente et al.   Nature Communications

Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty

(2019) Nicholas J. W. Rattray et al.   Nature Communications

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

(2019) Camilla S. L. Tuttle et al.   AGING CELL

Alternative splicing in aging and longevity

(2019) Malini Bhadra et al.   HUMAN GENETICS

Defining Adult Stem Cells by Function, not by Phenotype

(2018) Hans Clevers et al.   Annual Review of Biochemistry

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

The gut microbiota influences anticancer immunosurveillance and general health

(2018) Bertrand Routy et al.   Nature Reviews Clinical Oncology

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo

(2018) Markus C. Doeser et al.   STEM CELLS

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

(2018) Juan Manuel Povedano et al.   eLife

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Mouse Models to Disentangle the Hallmarks of Human Aging

(2018) Alicia R. Folgueras et al.   CIRCULATION RESEARCH

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

(2018) John J. McNeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Mitochondria-Targeted Drugs

(2018) Roman A. Zinovkin et al.   Current Molecular Pharmacology

Giant tortoise genomes provide insights into longevity and age-related disease

(2018) Víctor Quesada et al.   Nature Ecology & Evolution

Fine-tuning PERK signaling for neuroprotection

(2017) Mark Halliday et al.   JOURNAL OF NEUROCHEMISTRY

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

(2017) Yotam Raz et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

(2016) C. Bar et al.   BLOOD

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Whole-Genome Sequencing of a Healthy Aging Cohort

(2016) Galina A. Erikson et al.   CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

(2016) Sarah J. Mitchell et al.   Cell Metabolism

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Is Senescence Reversible?

(2016) Shweta Chakradeo et al.   CURRENT DRUG TARGETS

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

A Disease or Not a Disease? Aging As a Pathology

(2016) Timothy V. Gladyshev et al.   TRENDS IN MOLECULAR MEDICINE

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury

(2016) Xiang Gao et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

(2015) Cathy Slack et al.   CELL

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

(2015) Andrew C. Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

(2015) Natalia V. Bobkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

IGF-I regulates the age-dependent signaling peptide humanin

(2014) Changhan Lee et al.   AGING CELL

Progeria: A Paradigm for Translational Medicine

(2014) Leslie B. Gordon et al.   CELL

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

(2014) B. J. North et al.   EMBO JOURNAL

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

Collagenase-resistant collagen promotes mouse aging and vascular cell senescence

(2013) Faran Vafaie et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster

(2013) Eleni N. Tsakiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

(2010) Hae Ri Choi et al.   AGING CELL

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

(2008) Antonia Tomás-Loba et al.   CELL