Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

(2021) Martin Jinye Zhang et al.   eLife

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

(2021) Yanpu Chen et al.   SCIENCE

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

(2020) Matthew J. Yousefzadeh et al.   AGING CELL

Arid5a, an RNA-Binding Protein in Immune Regulation: RNA Stability, Inflammation, and Autoimmunity

(2020) Kishan Kumar Nyati et al.   TRENDS IN IMMUNOLOGY

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

(2020) Tapash Jay Sarkar et al.   Nature Communications

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair

(2020) Bi-Sen Ding et al.   DEVELOPMENTAL CELL

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

(2019) Qin-Li Wan et al.   Aging-US

The metabolomic signature of extreme longevity: naked mole rats versus mice

(2019) Mélanie Viltard et al.   Aging-US

The molecular functions of hepatocyte nuclear factors – In and beyond the liver

(2018) Hwee Hui Lau et al.   JOURNAL OF HEPATOLOGY

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

In vivo reprogramming drives Kras-induced cancer development

(2018) Hirofumi Shibata et al.   Nature Communications

DNA Methylation Clocks in Aging: Categories, Causes, and Consequences

(2018) Adam E. Field et al.   MOLECULAR CELL

Epigenetic age-predictor for mice based on three CpG sites

(2018) Yang Han et al.   eLife

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

(2018) Nelly Olova et al.   AGING CELL

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

lmerTest Package: Tests in Linear Mixed Effects Models

(2017) Alexandra Kuznetsova et al.   Journal of Statistical Software

Transplantation of Thy1+ Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling

(2017) Norihisa Ichinohe et al.   STEM CELLS

Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma

(2017) Yulin Guo et al.   Clinical Epigenetics

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Metabolomic study of aging in mouse plasma by gas chromatography–mass spectrometry

(2016) Chan Seo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

(2016) Makiko Iwafuchi-Doi et al.   MOLECULAR CELL

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Quantifying alternative splicing from paired-end RNA-sequencing data

(2014) David Rossell et al.   Annals of Applied Statistics

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Collagen matrix support of pancreatic islet survival and function

(2014) Matthew Riopel   Frontiers in Bioscience-Landmark

Altered MCM Protein Levels and Autophagic Flux in Aged and Systemic Sclerosis Dermal Fibroblasts

(2014) Verónica I. Dumit et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

DNA methylation analysis of murine hematopoietic side population cells during aging

(2013) Oluwatosin Taiwo et al.   Epigenetics

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

The role of DNA damage and repair in aging through the prism of Koch-like criteria

(2012) Alexey A. Moskalev et al.   AGEING RESEARCH REVIEWS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

ROAST: rotation gene set tests for complex microarray experiments

(2010) Di Wu et al.   BIOINFORMATICS

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

GaGa: A parsimonious and flexible model for differential expression analysis

(2009) David Rossell   Annals of Applied Statistics

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging

(2008) Thore C. Brink et al.   BIOGERONTOLOGY

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL