Somatic mutant clones colonize the human esophagus with age

Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues

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Cancer-Associated Mutations in Endometriosis without Cancer

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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

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Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

(2017) Jiang Chang et al.   Nature Communications

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

(2016) Genta Sawada et al.   GASTROENTEROLOGY

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

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Tissue-specific mutation accumulation in human adult stem cells during life

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Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma

(2015) Ling Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR

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(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

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(2015) I. Martincorena et al.   SCIENCE

High burden and pervasive positive selection of somatic mutations in normal human skin

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Subclonal variant calling with multiple samples and prior knowledge

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Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

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Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

(2014) Maria P. Alcolea et al.   NATURE CELL BIOLOGY

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

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Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

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(2013) B. Vogelstein et al.   SCIENCE

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

The Life History of 21 Breast Cancers

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Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms

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GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program

(2012) Amelia Soto Hopkin et al.   PLoS Genetics

NOTCH1 and NOTCH3 Coordinate Esophageal Squamous Differentiation Through a CSL-Dependent Transcriptional Network

(2010) Shinya Ohashi et al.   GASTROENTEROLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

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