Gut microbiota as the key controllers of “healthy” aging of elderly people

Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA

(2020) Naoko Satoh-Takayama et al.   IMMUNITY

Effects of probiotic supplementation on natural killer cell function in healthy elderly individuals: a meta-analysis of randomized controlled trials

(2020) Qifeng Gui et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

(2019) José Luís Fachi et al.   Cell Reports

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study

(2019) Nuria Salazar et al.   Nutrients

Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans

(2019) Jack Guinan et al.   Scientific Reports

The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health

(2019) Jillian L. Waters et al.   BMC BIOLOGY

Aging progression of human gut microbiota

(2019) Congmin Xu et al.   BMC MICROBIOLOGY

Enriched taxa were found among the gut microbiota of centenarians in East China

(2019) Na Wang et al.   PLoS One

Author Correction: Bidirectional regulatory potentials of short-chain fatty acids and their G-protein-coupled receptors in autoimmune neuroinflammation

(2019) Jeongho Park et al.   Scientific Reports

Effectiveness of probiotics on the occurrence of infections in older people: systematic review and meta-analysis

(2018) Patrick Alexander Wachholz et al.   AGE AND AGEING

The Gut Microbiota and Healthy Aging: A Mini-Review

(2018) Sangkyu Kim et al.   GERONTOLOGY

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

(2018) Pedro Gonçalves et al.   INFLAMMATORY BOWEL DISEASES

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

(2018) Mingming Sun et al.   Nature Communications

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

(2018) Monica Bodogai et al.   Science Translational Medicine

Biological Aging and the Human Gut Microbiota

(2017) Vincent J Maffei et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Akkermansia muciniphila and its role in regulating host functions

(2017) Muriel Derrien et al.   MICROBIAL PATHOGENESIS

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

(2017) Clara Belzer et al.   mBio

Gut dysbiosis following C-section instigates higher colonisation of toxigenic Clostridium perfringens in infants

(2017) R. Nagpal et al.   Beneficial Microbes

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

(2017) Meike Kespohl et al.   Frontiers in Immunology

Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort

(2017) Cian J. Hill et al.   Microbiome

Evolution of gut Bifidobacterium population in healthy Japanese infants over the first three years of life: a quantitative assessment

(2017) Ravinder Nagpal et al.   Scientific Reports

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

(2016) Fabian Rivera-Chávez et al.   Cell Host & Microbe

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Gut microbiota signatures of longevity

(2016) Fanli Kong et al.   CURRENT BIOLOGY

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Aging Converts Innate B1a Cells into Potent CD8+T Cell Inducers

(2016) Catalina Lee-Chang et al.   JOURNAL OF IMMUNOLOGY

Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys

(2016) E. L. Mitchell et al.   Journal of Nutrition Health & Aging

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

Oscillospira : a Central, Enigmatic Component of the Human Gut Microbiota

(2016) Tom Konikoff et al.   TRENDS IN MICROBIOLOGY

Signatures of early frailty in the gut microbiota

(2016) Matthew A. Jackson et al.   Genome Medicine

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

(2016) Melissa N. Conley et al.   PeerJ

Functional metagenomic profiling of intestinal microbiome in extreme ageing

(2016) Simone Rampelli et al.   Aging-US

Dietary Fiber Intake Regulates Intestinal Microflora and Inhibits Ovalbumin-Induced Allergic Airway Inflammation in a Mouse Model

(2016) Zhiyu Zhang et al.   PLoS One

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth

(2015) Peyman Ghorbani et al.   EUROPEAN RESPIRATORY JOURNAL

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

(2015) Jing Cheng et al.   ISME Journal

Composition and temporal stability of the gut microbiota in older persons

(2015) Ian B Jeffery et al.   ISME Journal

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Gut microbiota and aging

(2015) P. W. OToole et al.   SCIENCE

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity

(2014) C. Lee-Chang et al.   BLOOD

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Microbial shifts in the aging mouse gut

(2014) Morgan GI Langille et al.   Microbiome

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

(2013) Myriam N. Bouchlaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

(2013) Sebastiano Collino et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The interaction between gut microbiota and age-related changes in immune function and inflammation

(2013) Thea Magrone et al.   Immunity & Ageing

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Dietary and social modulation of gut microbiota in the elderly

(2012) James Kinross et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular monitoring of the development of intestinal microbiota in Japanese infants

(2012) H. Tsuji et al.   Beneficial Microbes

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

(2012) Trond Ulven   Frontiers in Endocrinology

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota

(2011) M. C. Rea et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Influence of gut microbiota on mouse B2 B cell ontogeny and function

(2011) Jenny Hansson et al.   MOLECULAR IMMUNOLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production

(2011) Mitsuharu Matsumoto et al.   PLoS One

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

(2011) B. D. Muegge et al.   SCIENCE

Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization

(2010) Christina L. Sherry et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcriptional Attenuation in Colon Carcinoma Cells in Response to Butyrate

(2010) M. C. Daroqui et al.   Cancer Prevention Research

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Human intestinal microbiota and healthy ageing

(2009) Kirsti Tiihonen et al.   AGEING RESEARCH REVIEWS

The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition

(2009) Harri Mäkivuokko et al.   BRITISH JOURNAL OF NUTRITION

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

(2009) Petra Louis et al.   FEMS MICROBIOLOGY LETTERS

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

(2008) Muthusamy Thangaraju et al.   BIOCHEMICAL JOURNAL

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH

The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

(2008) D. A. Sela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA