T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

An evolutionary perspective on immunometabolism

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Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

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Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

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Find drugs that delay many diseases of old age

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mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

(2018) Nicole M. Chapman et al.   Nature Communications

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

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TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

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De novo NAD+ synthesis enhances mitochondrial function and improves health

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Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

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Emerging concepts of T cell metabolism as a target of immunotherapy

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NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

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NAD+ in aging, metabolism, and neurodegeneration

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

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T-helper-1-cell cytokines drive cancer into senescence

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

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