Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

(2022) Róbert Pálovics et al.   NATURE

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

(2021) Theodore T. Ho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

(2021) M. Grunewald et al.   SCIENCE

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

(2021) Yan Sun et al.   Science Advances

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

(2020) Si Wang et al.   CELL

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The aging skin microenvironment dictates stem cell behavior

(2020) Yejing Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging-induced IL27Ra Signaling Impairs Hematopoietic Stem Cells

(2020) Hanqing He et al.   BLOOD

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

(2020) Xuemei Xie et al.   NATURE IMMUNOLOGY

A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging

(2020) Jingyi Li et al.   National Science Review

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

(2020) Simona Valletta et al.   Nature Communications

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

(2020) Wakako Kuribayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Single-Cell Transcriptomic Atlas of Human Skin Aging

(2020) Zhiran Zou et al.   DEVELOPMENTAL CELL

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

(2019) Xing Zhang et al.   Protein & Cell

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

(2019) Emmalee R Adelman et al.   Cancer Discovery

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

(2019) Masayuki Yamashita et al.   Cell Stem Cell

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

(2019) Kathlyn J. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

(2018) Simon Haas et al.   Cell Stem Cell

CCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis

(2018) Dabin Lee et al.   Cell Death & Disease

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers

(2018) Rhonda J. Staversky et al.   Scientific Reports

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

A20 deficiency in multipotent progenitors perturbs quiescence of hematopoietic stem cells

(2018) Masahiro Marshall Nakagawa et al.   Stem Cell Research

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

(2016) A. Sinclair et al.   BLOOD

Dissecting the bone marrow HSC niches

(2016) Meng Zhao et al.   CELL RESEARCH

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

(2016) Suguna Rani Krishnaswami et al.   Nature Protocols

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

(2016) Amit Grover et al.   Nature Communications

ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver

(2015) Y. Zhao et al.   BLOOD

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

Blood-Borne Revitalization of the Aged Brain

(2015) Joseph M. Castellano et al.   JAMA Neurology

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential

(2012) T. Shimazu et al.   BLOOD

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2012) Jianwei Wang et al.   CELL

i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules

(2012) Carl Herrmann et al.   NUCLEIC ACIDS RESEARCH

Accelerated Aging versus Rejuvenation of the Immune System in Heterochronic Parabiosis

(2012) Iryna Pishel et al.   REJUVENATION RESEARCH

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche

(2011) M. Rehn et al.   BLOOD

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal

(2009) Marianne Santaguida et al.   CANCER CELL

Aging in the lympho-hematopoietic stem cell compartment

(2009) Hartmut Geiger et al.   TRENDS IN IMMUNOLOGY