Cytoplasmic DNA: sources, sensing, and role in aging and disease

A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

(2021) Hong Sun et al.   Cell Reports

Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation

(2021) Yan Wang et al.   IMMUNITY

Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration

(2021) Shinichi Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation and chromatin tethering prevent cGAS activation during mitosis

(2021) Tuo Li et al.   SCIENCE

CGAS is a micronucleophagy receptor for the clearance of micronuclei

(2021) Mengmeng Zhao et al.   Autophagy

Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

(2021) Julio Aguado et al.   AGING CELL

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

(2021) Jery Joy et al.   DEVELOPMENTAL CELL

Nuclear cGAS: guard or prisoner?

(2021) Carina C Oliveira Mann et al.   EMBO JOURNAL

Virus-induced senescence is driver and therapeutic target in COVID-19

(2021) Soyoung Lee et al.   NATURE

The role of retrotransposable elements in ageing and age-associated diseases

(2021) Vera Gorbunova et al.   NATURE

Senolytics reduce coronavirus-related mortality in old mice

(2021) Christina D. Camell et al.   SCIENCE

53BP1: a DSB escort

(2020) Zachary Mirman et al.   GENES & DEVELOPMENT

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

The anti-viral dynamin family member MxB participates in mitochondrial integrity

(2020) Hong Cao et al.   Nature Communications

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

(2020) Bo Zhao et al.   Nature Communications

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

The World Goes Bats: Living Longer and Tolerating Viruses

(2020) Vera Gorbunova et al.   Cell Metabolism

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

(2020) Baoyu Zhao et al.   NATURE

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

SIRT1 is downregulated by autophagy in senescence and ageing

(2020) Caiyue Xu et al.   NATURE CELL BIOLOGY

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

(2020) Jasper Iske et al.   Nature Communications

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

(2020) Junhong Guan et al.   CANCER CELL

cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

(2020) Carolina Uggenti et al.   NATURE GENETICS

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

(2019) Yuk Yuen Lan et al.   AGING CELL

A non‐death function of the mitochondrial apoptosis apparatus in immunity

(2019) Dominik Brokatzky et al.   EMBO JOURNAL

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Micronuclei and Genome Chaos: Changing the System Inheritance

(2019) Christine J. Ye et al.   Genes

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

(2019) James Chapman et al.   FEBS LETTERS

Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences

(2019) Xuan Song et al.   JOURNAL OF NEUROSCIENCE

SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina

(2019) Berta N Vazquez et al.   NUCLEIC ACIDS RESEARCH

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance

(2019) Larysa V. Yuzefovych et al.   PLoS One

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

(2018) Athena Georgilis et al.   CANCER CELL

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

The epigenetic alterations of endogenous retroelements in aging

(2018) Maurizio Cardelli   MECHANISMS OF AGEING AND DEVELOPMENT

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Senotherapeutics for healthy ageing

(2018) Laura J. Niedernhofer et al.   NATURE REVIEWS DRUG DISCOVERY

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Caloric restriction and cellular senescence

(2018) Luigi Fontana et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

cGAS Micro-Manages Genotoxic Stress

(2017) Mona Motwani et al.   IMMUNITY

DNA damage-induced immune response: Micronuclei provide key platform

(2017) Nelson O. Gekara   JOURNAL OF CELL BIOLOGY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Mobile DNA in Health and Disease

(2017) Haig H. Kazazian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity

(2017) Taranjit Singh Rai et al.   NUCLEIC ACIDS RESEARCH

Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in Taiwan

(2017) Pei-Ying Wu et al.   PLoS One

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Evidence Suggesting Absence of Mitochondrial DNA Methylation

(2017) Mie Mechta et al.   Frontiers in Genetics

Dengue virus activates cGAS through the release of mitochondrial DNA

(2017) Bo Sun et al.   Scientific Reports

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

(2017) Thomas Briston et al.   Scientific Reports

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

(2016) Antonia Di Micco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Restricting retrotransposons: a review

(2016) John L. Goodier   Mobile DNA

Cell senescence is an antiviral defense mechanism

(2016) Maite Baz-Martínez et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

What might retrotransposons teach us about aging?

(2015) Patrick H. Maxwell   CURRENT GENETICS

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia

(2014) Aksana Kaefer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

The origins and processing of ultra fine anaphase DNA bridges

(2014) Ying Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

LINE-1 of Evidence for Fetal Oocyte Attrition by Retrotransposon

(2014) Shinichiro Chuma   DEVELOPMENTAL CELL

A Role for Retrotransposon LINE-1 in Fetal Oocyte Attrition in Mice

(2014) Safia Malki et al.   DEVELOPMENTAL CELL

Antiretroviral Therapy

(2014) Alice K. Pau et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Association of CHMP4B and Autophagy with Micronuclei: Implications for Cataract Formation

(2014) Antonia P. Sagona et al.   Biomed Research International

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Clinical significance of serum mitochondrial DNA in lung cancer

(2013) Yu-Lei Hou et al.   CLINICAL BIOCHEMISTRY

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging

(2013) Edwin Leeansyah et al.   JOURNAL OF INFECTIOUS DISEASES

Regionally Specific and Genome-Wide Analyses Conclusively Demonstrate the Absence of CpG Methylation in Human Mitochondrial DNA

(2013) E. E. Hong et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Activation of transposable elements during aging and neuronal decline in Drosophila

(2013) Wanhe Li et al.   NATURE NEUROSCIENCE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Mitochondrial Regulation of Cell Death

(2013) S. W. G. Tait et al.   Cold Spring Harbor Perspectives in Biology

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

(2012) Remi-Martin Laberge et al.   AGING CELL

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

(2012) Kyle R. Hukezalie et al.   PLoS One

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

(2012) Z. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

C. elegans Germ Cells Show Temperature and Age-Dependent Expression of Cer1, a Gypsy/Ty3-Related Retrotransposon

(2012) Shannon Dennis et al.   PLoS Pathogens

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

(2011) Evi M. Mercken et al.   AGEING RESEARCH REVIEWS

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition

(2011) Lixin Dai et al.   BMC BIOCHEMISTRY

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

(2011) Hiroki Kaneko et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Retrotransposition is associated with genome instability during chronological aging

(2011) P. H. Maxwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Human mitochondrial transcription factor A is required for the segregation of mitochondrial DNA in cultured cells

(2010) Katsumi Kasashima et al.   EXPERIMENTAL CELL RESEARCH

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Levels of Circulating Cell-Free Nuclear and Mitochondrial DNA in Benign and Malignant Ovarian Tumors

(2010) Rebecca R. Zachariah et al.   OBSTETRICS AND GYNECOLOGY

Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker

(2009) Jörg Ellinger et al.   BJU INTERNATIONAL

Nuclear lamins: key regulators of nuclear structure and activities

(2009) Miron Prokocimer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

(2008) John L. Goodier et al.   CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition

(2008) R. Brad Jones et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY