Alternative splicing in aging and longevity

Introns are mediators of cell response to starvation

(2019) Julie Parenteau et al.   NATURE

Excised linear introns regulate growth in yeast

(2019) Jeffrey T. Morgan et al.   NATURE

Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer’s disease

(2019) Swarnaseetha Adusumalli et al.   AGING CELL

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood

(2019) Benjamin P. Lee et al.   BIOGERONTOLOGY

Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels

(2019) Benjamin P. Lee et al.   EXPERIMENTAL GERONTOLOGY

mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control

(2019) Jae-Woong Chang et al.   NUCLEIC ACIDS RESEARCH

Proper splicing contributes to visual function in the aging Drosophila eye

(2018) Rachel Stegeman et al.   AGING CELL

Global accumulation of circRNAs during aging in Caenorhabditis elegans

(2018) Mariela Cortés-López et al.   BMC GENOMICS

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys

(2018) Timothy W. Rhoads et al.   Cell Metabolism

FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence

(2018) Eva Latorre et al.   FASEB JOURNAL

Comprehensive map of age-associated splicing changes across human tissues and their contributions to age-associated diseases

(2018) Kun Wang et al.   Scientific Reports

NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells

(2018) Mohammed E. Sayed et al.   ONCOGENE

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells

(2017) Ilaria Passacantilli et al.   NUCLEIC ACIDS RESEARCH

Beyond Read-Counts: Ribo-seq Data Analysis to Understand the Functions of the Transcriptome

(2017) Lorenzo Calviello et al.   TRENDS IN GENETICS

Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity

(2017) Syed Shamsh Tabrez et al.   Nature Communications

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

(2017) Heehwa G. Son et al.   Nature Communications

Biological Age Predictors

(2017) Juulia Jylhävä et al.   EBioMedicine

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

(2016) Benjamin P. Lee et al.   AGING CELL

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

Modulation of nonsense mediated decay by rapamycin

(2016) Rocio T. Martinez-Nunez et al.   NUCLEIC ACIDS RESEARCH

Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

(2016) Pushkar Malakar et al.   Scientific Reports

CircRNA accumulation in the aging mouse brain

(2016) Hannah Gruner et al.   Scientific Reports

Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging

(2015) Sofía A. Rodríguez et al.   AGING CELL

Combinatorial control ofDrosophilacircular RNA expression by intronic repeats, hnRNPs, and SR proteins

(2015) Marianne C. Kramer et al.   GENES & DEVELOPMENT

Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis

(2015) Jingwen Song et al.   MOLECULAR AND CELLULAR BIOLOGY

mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

(2015) Jae-Woong Chang et al.   Nature Communications

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Widespread intron retention in mammals functionally tunes transcriptomes

(2014) Ulrich Braunschweig et al.   GENOME RESEARCH

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer

(2014) Ioannis Sanidas et al.   MOLECULAR CELL

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus

(2014) Roman M. Stilling et al.   Frontiers in Cellular Neuroscience

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

Embryonic expression of the common progeroid lamin A splice mutation arrests postnatal skin development

(2013) Tomás McKenna et al.   AGING CELL

Dynamic Integration of Splicing within Gene Regulatory Pathways

(2013) Ulrich Braunschweig et al.   CELL

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

Changes in splicing factor expression are associated with advancing age in man

(2013) Alice C. Holly et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Competition between Pre-mRNAs for the Splicing Machinery Drives Global Regulation of Splicing

(2013) Elizabeth M. Munding et al.   MOLECULAR CELL

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

RSR-2, the Caenorhabditis elegans Ortholog of Human Spliceosomal Component SRm300/SRRM2, Regulates Development by Influencing the Transcriptional Machinery

(2013) Laura Fontrodona et al.   PLoS Genetics

The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus

(2012) Zhihong Zhou et al.   MOLECULAR CELL

The Sam68 STAR RNA-Binding Protein Regulates mTOR Alternative Splicing during Adipogenesis

(2012) Marc-Étienne Huot et al.   MOLECULAR CELL

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

(2012) Y Tang et al.   ONCOGENE

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

Pre-mRNA splicing in disease and therapeutics

(2012) Ravi K. Singh et al.   TRENDS IN MOLECULAR MEDICINE

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1

(2012) Vered Ben-Hur et al.   Cell Reports

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

(2011) Lorna W. Harries et al.   AGING CELL

Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence

(2011) Francisco J. Blanco et al.   AGING CELL

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

(2011) J. R. Tollervey et al.   GENOME RESEARCH

A conserved splicing mechanism of the LMNA gene controls premature aging

(2011) Isabel C. Lopez-Mejia et al.   HUMAN MOLECULAR GENETICS

Evolution of SR protein and hnRNP splicing regulatory factors

(2011) Anke Busch et al.   Wiley Interdisciplinary Reviews-RNA

Recent trends in chronic disease, impairment and disability among older adults in the United States

(2011) William W Hung et al.   BMC Geriatrics

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

Akt2 Regulation of Cdc2-Like Kinases (Clk/Sty), Serine/Arginine-Rich (SR) Protein Phosphorylation, and Insulin-Induced Alternative Splicing of PKCβII Messenger Ribonucleic Acid

(2008) Kun Jiang et al.   ENDOCRINOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE