Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice

Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH

(2021) Leigh Goedeke et al.   Molecular Metabolism

Targeting the Mitochondria-Proteostasis Axis to Delay Aging

(2021) Andreas Zimmermann et al.   Frontiers in Cell and Developmental Biology

Circadian regulation of mitochondrial uncoupling and lifespan

(2020) Matt Ulgherait et al.   Nature Communications

Long-Term Feeding of a High-Fat Diet Ameliorated Age-Related Phenotypes in SAMP8 Mice

(2020) Hideaki Oike et al.   Nutrients

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

(2020) Ying Ann Chiao et al.   eLife

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

(2020) Kun Lyu et al.   Cell Metabolism

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

(2020) Abudukadier Abulizi et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial pathways in human health and aging

(2020) Rebecca Bornstein et al.   MITOCHONDRION

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

(2019) Frode Norheim et al.   Cell Metabolism

Cellular energetics and mitochondrial uncoupling in canine aging

(2019) Justin W. Nicholatos et al.   GeroScience

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

(2019) Leigh Goedeke et al.   Science Translational Medicine

Current nutritional and pharmacological anti-aging interventions

(2019) Manuel Ros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Free Radical Theory of Frailty

(2018) Jose Viña et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

(2018) Leigh Goedeke et al.   HEPATOLOGY

The impact of aging, calorie restriction and dietary fat on mitochondrial ultrastructure, dynamics and autophagy markers in mouse skeletal muscle

(2018) Elena Gutiérrez-Casado et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4

(2018) Wei He et al.   Scientific Reports

Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer

(2018) Yongliang Wang et al.   Cell Reports

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

(2018) Hao Shi et al.   Molecular Metabolism

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice

(2018) Abudukadier Abulizi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice

(2017) Abudukadier Abulizi et al.   FASEB JOURNAL

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

(2017) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

Caloric Restriction Research: New Perspectives on the Biology of Aging

(2017) Rozalyn M Anderson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

(2017) Darren J. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

(2017) Kasper W. ter Horst et al.   Cell Reports

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

(2016) Sarah J. Mitchell et al.   Cell Metabolism

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy

(2016) Valéria Nunes-Souza et al.   Oxidative Medicine and Cellular Longevity

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

(2016) Yih-Woei C. Fridell et al.   Aging-US

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Obesity induced by high fat diet attenuates postinfarct myocardial remodeling and dysfunction in adult B6D2F1 mice

(2015) Marcos Poncelas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Oxidative Stress Is Related to Frailty, Not to Age or Sex, in a Geriatric Population: Lipid and Protein Oxidation as Biomarkers of Frailty

(2014) Marta Inglés et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

(2014) Dimitry A. Chistiakov et al.   Biomed Research International

Off-label use of hormones as an antiaging strategy: a review

(2014) Nikolaos Samaras et al.   Clinical Interventions in Aging

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Many Faces of Mitochondrial Uncoupling During Age: Damage or Defense?

(2013) F. Bellanti et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies

(2013) Maria Fedorova et al.   MASS SPECTROMETRY REVIEWS

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Pathobiology of Aging Mice and GEM

(2012) C. F. Brayton et al.   VETERINARY PATHOLOGY

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Mitochondrial uncoupling and lifespan

(2010) Shona A. Mookerjee et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Diet-induced Obesity in Two C57BL/6 Substrains With Intact or Mutant Nicotinamide Nucleotide Transhydrogenase (Nnt) Gene

(2010) Anthony Nicholson et al.   Obesity

C. elegans longevity pathways converge to decrease mitochondrial membrane potential

(2009) Bernard D. Lemire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage

(2009) N. Neretti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL