Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

(2020) Jingwei Ma et al.   Nature Communications

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease

(2018) Esha Gauba et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

(2018) David E. Sanin et al.   IMMUNITY

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

(2017) Tomohiro Aoki et al.   Science Signaling

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

(2017) Tomohiro Aoki et al.   Science Signaling

Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE2 Signaling in Alzheimer’s Disease

(2016) Nathaniel S. Woodling et al.   ACS Chemical Neuroscience

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome

(2016) Vishaldeep K. Sidhu et al.   NEUROBIOLOGY OF AGING

Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs

(2016) Amira Latif-Hernandez et al.   Frontiers in Cellular Neuroscience

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

A comprehensive quantification method for eicosanoids and related compounds by using liquid chromatography/mass spectrometry with high speed continuous ionization polarity switching

(2015) Masaki Yamada et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A Selective Prostaglandin E2 Receptor Subtype 2 (EP2) Antagonist Increases the Macrophage-Mediated Clearance of Amyloid-Beta Plaques

(2015) Brian M. Fox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

(2015) Colm Cunningham et al.   Alzheimers Research & Therapy

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

(2014) Jenny U. Johansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage

(2014) Atsushi Yamashita et al.   PLoS One

Human cognitive aging: Corriger la fortune?

(2014) U. Lindenberger   SCIENCE

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia

(2013) J. U. Johansson et al.   JOURNAL OF NEUROSCIENCE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease

(2013) Aida Attar et al.   PLoS One

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist

(2011) KJ af Forselles et al.   BRITISH JOURNAL OF PHARMACOLOGY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Aging impairs hippocampus-dependent long-term memory for object location in mice

(2011) Mathieu E. Wimmer et al.   NEUROBIOLOGY OF AGING