Hallmarks of T cell aging

A fresh look at the T helper subset dogma

(2021) Jasper J. P. van Beek et al.   NATURE IMMUNOLOGY

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

(2021) Ke Xu et al.   SCIENCE

T-cell senescence accelerates Angiotensin II-induced target organ damage

(2020) Xiao-Xi Pan et al.   CARDIOVASCULAR RESEARCH

Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

(2020) Nina Dumauthioz et al.   Cellular & Molecular Immunology

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

(2020) Hassen Kared et al.   Nature Communications

Sexual-dimorphism in human immune system aging

(2020) Eladio J. Márquez et al.   Nature Communications

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

(2020) Leo Swadling et al.   Cell Reports

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

(2020) Andrew G. Ramstead et al.   Cell Reports

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

(2020) Rachel Thomas et al.   Immunity & Ageing

A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation

(2020) Michiel G. H. Betjes et al.   Immunity & Ageing

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity

(2020) Daniel DiToro et al.   IMMUNITY

Can blocking inflammation enhance immunity during aging?

(2020) Emma S. Chambers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulating T cell differentiation through the polyamine spermidine

(2020) Guilhermina M. Carriche et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T Cell–Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation

(2020) H. Atakan Ekiz et al.   JOURNAL OF IMMUNOLOGY

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

(2020) Kilian Schober et al.   NATURE IMMUNOLOGY

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

(2020) Shota Yoshida et al.   Nature Communications

Uremia-Associated Ageing of the Thymus and Adaptive Immune Responses

(2020) Michiel GH Betjes   Toxins

FOXO1 deficiency impairs proteostasis in aged T cells

(2020) Jun Jin et al.   Science Advances

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

(2020) Ji Sun Moon et al.   AGING CELL

Chromosomal alterations among age-related haematopoietic clones in Japan

(2020) Chikashi Terao et al.   NATURE

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

(2020) Santosha A. Vardhana et al.   NATURE IMMUNOLOGY

The function of the thymus and its impact on modern medicine

(2020) Jacques F. A. P. Miller   SCIENCE

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

(2020) Aitziber Buqué et al.   Nature Communications

When the Damage Is Done: Injury and Repair in Thymus Function

(2020) Sinéad Kinsella et al.   Frontiers in Immunology

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

(2020) Maha Almanan et al.   Science Advances

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblast (FREF) to counteract age-related inflammation

(2020) Jiyoung Oh et al.   JCI Insight

How age and infection history shape the antigen‐specific CD8 + T‐cell repertoire: Implications for vaccination strategies in older adults

(2020) Josien Lanfermeijer et al.   AGING CELL

DCAF1 regulates Treg senescence via the ROS axis during immunological aging

(2020) Zengli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

(2020) Yi-Ru Yu et al.   NATURE IMMUNOLOGY

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

(2020) Julia Böhme et al.   Nature Communications

Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair

(2020) Yehezqel Elyahu et al.   AGEING RESEARCH REVIEWS

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

CD57+ Memory T Cells Proliferate In Vivo

(2020) Raya Ahmed et al.   Cell Reports

New Insights into Lymphocyte Differentiation and Aging from Telomere Length and Telomerase Activity Measurements

(2019) Tinhinane Fali et al.   JOURNAL OF IMMUNOLOGY

Impact of CMV upon immune aging: facts and fiction

(2019) Mladen Jergović et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion

(2019) Huang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of the Thymus in the Immune Response

(2019) Puspa Thapa et al.   Thoracic Surgery Clinics

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

(2019) Yun Ji et al.   Nature Communications

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

When Fasting Gets Tough, the Tough Immune Cells Get Going—or Die

(2019) Roberta Buono et al.   CELL

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Restoring thymic function: Then and now

(2019) Abed El-Hakim El-Kadiry et al.   CYTOKINE

T and B‐cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity

(2019) Silvia Preite et al.   IMMUNOLOGICAL REVIEWS

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

(2019) Yehezqel Elyahu et al.   Science Advances

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

(2019) Arsun Bektas et al.   Aging-US

Polyamines reverse immune senescence via the translational control of autophagy

(2019) Hanlin Zhang et al.   Autophagy

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

(2019) Ke-qi Fan et al.   CELL

Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence

(2019) Yoshiyuki Arata et al.   GENES TO CELLS

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

(2019) Kosuke Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

(2019) Chulwoo Kim et al.   Cell Reports

Cell generation dynamics underlying naive T-cell homeostasis in adult humans

(2019) Jeff E. Mold et al.   PLOS BIOLOGY

Autophagy in T Cell Function and Aging

(2019) Fernando Macian   Frontiers in Cell and Developmental Biology

Mitochondrial mass governs the extent of human T cell senescence

(2019) Lauren A. Callender et al.   AGING CELL

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood

(2018) Niharika Arora Duggal et al.   AGING CELL

Proteodynamics in aging human T cells – The need for its comprehensive study to understand the fine regulation of T lymphocyte functions

(2018) Jacek M. Witkowski et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial activity in T cells

(2018) Gabriela Desdín-Micó et al.   MITOCHONDRION

Thymic involution and rising disease incidence with age

(2018) Sam Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

(2018) Martine J. Kallemeijn et al.   Frontiers in Immunology

Impaired CMV Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres

(2018) Iulia Popescu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients

(2018) Thomas Crépin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

(2018) Junpei Suzuki et al.   Nature Communications

Regulation of miR-181a expression in T cell aging

(2018) Zhongde Ye et al.   Nature Communications

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

(2018) Evgeny S. Egorov et al.   Frontiers in Immunology

Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians

(2018) Enzo Tedone et al.   AGING CELL

Short telomere syndromes cause a primary T cell immunodeficiency

(2018) Christa L. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction

(2018) Souheil-Antoine Younes et al.   JOURNAL OF CLINICAL INVESTIGATION

Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life

(2018) Takashi Senda et al.   Mucosal Immunology

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

(2018) Noga Ron-Harel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence

(2018) Weili Xu et al.   EBioMedicine

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation

(2017) Milica Vukmanovic-Stejic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The chromatin accessibility signature of human immune aging stems from CD8+T cells

(2017) Duygu Ucar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+T Cells

(2017) Kyosuke Sato et al.   JOURNAL OF IMMUNOLOGY

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

(2017) Yotam Raz et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity

(2016) Takuya Maeda et al.   CANCER RESEARCH

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

Reduced T-Cell Thymic Export Reflected by sj-TREC in Patients with Coronary Artery Disease

(2016) Shuaibo Huang et al.   Journal of Atherosclerosis and Thrombosis

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

(2016) F Thol et al.   LEUKEMIA

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

(2016) Yun-Hee Youm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner

(2016) Jason T. White et al.   Nature Communications

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

(2016) Agnieszka M Kabat et al.   eLife

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

(2016) Julie S Lefebvre et al.   Scientific Reports

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Naive T Cell Maintenance and Function in Human Aging

(2015) Jörg J. Goronzy et al.   JOURNAL OF IMMUNOLOGY

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency

(2014) P. Stepensky et al.   BLOOD

miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation

(2014) Ruozhen Hu et al.   IMMUNITY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Thymus and aging: morphological, radiological, and functional overview

(2013) Rita Rezzani et al.   AGE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34

(2013) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells

(2013) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Thymic Involution: Where Endocrinology Meets Immunology

(2011) Adrienne E. Calder et al.   NEUROIMMUNOMODULATION

Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice

(2010) Yee Ting Wong et al.   AGE

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

(2009) Evelyna Derhovanessian et al.   CURRENT OPINION IN IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE