Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

Nuclear Stiffness Decreases with Disruption of the Extracellular Matrix in Living Tissues

(2021) Kaitlin P. McCreery et al.   Small

Identification of Common Genes and Pathways in Eight Fibrosis Diseases

(2021) Chang Gu et al.   Frontiers in Genetics

Mechanotranduction Pathways in the Regulation of Mitochondrial Homeostasis in Cardiomyocytes

(2021) Hongyu Liao et al.   Frontiers in Cell and Developmental Biology

Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis

(2021) Luis Placido et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T-cell senescence accelerates Angiotensin II-induced target organ damage

(2020) Xiao-Xi Pan et al.   CARDIOVASCULAR RESEARCH

The ECM path of senescence in aging: components and modifiers

(2020) Naama Levi et al.   FEBS Journal

Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

(2020) Marie Helena Docherty et al.   Frontiers in Pharmacology

Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments

(2020) Xiaoqiang Tang et al.   Frontiers in Endocrinology

Wnt signaling pathway in aging-related tissue fibrosis and therapies

(2020) He-He Hu et al.   AGEING RESEARCH REVIEWS

Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease

(2020) Pablo Astudillo   BIOCHEMICAL SOCIETY TRANSACTIONS

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Hypersensitivity pneumonitis

(2020) Ulrich Costabel et al.   Nature Reviews Disease Primers

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

(2020) Alexander Fedintsev et al.   AGEING RESEARCH REVIEWS

The Interplay of the Genetic Architecture, Aging, and Environmental Factors in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2020) Annie Pardo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

(2020) Kaj E.C. Blokland et al.   CLINICAL SCIENCE

Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

(2020) Mark Sweeney et al.   EMBO Molecular Medicine

Mitochondrial dysfunction in fibrotic diseases

(2020) Xinyu Li et al.   Cell Death Discovery

Active biomaterials for mechanobiology

(2020) Berna Özkale et al.   BIOMATERIALS

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

(2020) Jie Xu et al.   Frontiers in Pharmacology

Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer

(2020) Minjeong Jang et al.   Nature Biomedical Engineering

Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells

(2020) Mi Hu et al.   Bioactive Materials

Cellular nanoscale stiffness patterns governed by intracellular forces

(2019) Nicola Mandriota et al.   NATURE MATERIALS

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

(2019) Farid Alisafaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysyl oxidases: from enzyme activity to extracellular matrix cross-links

(2019) Sylvain D. Vallet et al.   Essays in Biochemistry

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

(2019) Antonio Totaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver stiffness correlates with serum osteopontin and TAZ expression in human liver cirrhosis

(2019) Zohreh Khajehahmadi et al.   Annals of the New York Academy of Sciences

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Measuring biological aging in humans: A quest

(2019) Luigi Ferrucci et al.   AGING CELL

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

(2018) Sandybell Anorga et al.   FASEB JOURNAL

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

(2018) Jonathan A. Kropski et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

(2018) Mariëlle Walraven et al.   MATRIX BIOLOGY

The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature

(2018) Maria De Luca   MECHANISMS OF AGEING AND DEVELOPMENT

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations

(2018) Marissa J. Schafer et al.   Current Rheumatology Reports

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

(2018) Mark G Jones et al.   eLife

The lung in rheumatoid arthritis - focus on interstitial lung disease

(2018) Paolo Spagnolo et al.   Arthritis & Rheumatology

YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

(2018) Satoshi Noguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse

(2018) Selma Osmanagic-Myers et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

(2018) Marta Varela-Eirín et al.   Cell Death & Disease

Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors

(2017) Erzsébet Bartolák-Suki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

(2016) Yair Romero et al.   AGING CELL

Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis

(2016) Aaron R. Froese et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Notch: A multi-functional integrating system of microenvironmental signals

(2016) Bryce LaFoya et al.   DEVELOPMENTAL BIOLOGY

Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis

(2016) Moisés Selman et al.   EUROPEAN RESPIRATORY JOURNAL

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Extracellular matrix stiffness dictates Wnt expression through integrin pathway

(2016) Jing Du et al.   Scientific Reports

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

(2015) A. Gutierrez-Fernandez et al.   EMBO JOURNAL

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cutaneous wound healing in aging small mammals: a systematic review

(2015) Dong Joo Kim et al.   WOUND REPAIR AND REGENERATION

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients

(2013) Mazen Noureddin et al.   HEPATOLOGY

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure

(2011) Stephanie Alexander et al.   TRENDS IN MOLECULAR MEDICINE

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

(2010) Hae Ri Choi et al.   AGING CELL

Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest)

(2010) Thierry Poynard et al.   BMC GASTROENTEROLOGY

CD28 Down-Regulation on Circulating CD4 T-Cells Is Associated with Poor Prognoses of Patients with Idiopathic Pulmonary Fibrosis

(2010) Syed R. Gilani et al.   PLoS One

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL