Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster

(2016) Johannes H. Bauer et al.   Aging-US

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

(2016) Eugenia Morselli et al.   Aging-US

dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction

(2016) Vijay Parashar et al.   Aging-US

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy

(2016) Sean M. Armour et al.   Aging-US

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

(2016) Brenda Rascón et al.   Aging-US

Sirt1 activation by resveratrol is substrate sequence-selective

(2016) Mahadevan Lakshminarasimhan et al.   Aging-US

Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila

(2016) Julia Hoffmann et al.   Aging-US

Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner

(2016) Rachel Whitaker et al.   Aging-US

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation

(2015) Jessica L. Feldman et al.   BIOCHEMISTRY

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

(2015) Zhu Xu et al.   CELL CYCLE

SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

(2015) Myeong Jin Yoon et al.   Cell Metabolism

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-ageing pill pushed as bona fide drug

(2015) Erika Check Hayden   NATURE

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

(2015) Shangyu Hong et al.   NATURE MEDICINE

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

(2015) Clémence D Côté et al.   NATURE MEDICINE

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual FishNothobranchius guentheri

(2015) Tingting Liu et al.   REJUVENATION RESEARCH

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs

(2015) Fiorella Ghisays et al.   Cell Reports

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous

(2015) Szu-Chieh Mei et al.   PLOS BIOLOGY

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

(2015) James G. Krueger et al.   PLoS One

Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

(2014) Natalie Moroz et al.   AGING CELL

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage

(2014) Krishna S. Tummala et al.   CANCER CELL

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

SnapShot: Sirtuins, NAD, and Aging

(2014) Takashi Nakagawa et al.   Cell Metabolism

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

(2014) Melroy X. Miranda et al.   EUROPEAN HEART JOURNAL

Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis

(2014) Heather A. Hausenblas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol

(2014) Mathew Sajish et al.   NATURE

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

(2014) Richard D. Semba et al.   JAMA Internal Medicine

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

(2013) Yolanda Jimenez-Gomez et al.   Cell Metabolism

NAD+metabolism: A therapeutic target for age-related metabolic disease

(2013) Laurent Mouchiroud et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

(2013) Joao Tomé-Carneiro et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol Prevents  -Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

(2013) J. L. Fiori et al.   DIABETES

Early combination therapy for the treatment of type 2 diabetes mellitus: systematic review and meta-analysis

(2013) O. J. Phung et al.   DIABETES OBESITY & METABOLISM

Longitudinal Trajectories of Arterial Stiffness and the Role of Blood Pressure

(2013) Majd AlGhatrif et al.   HYPERTENSION

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+Biosynthesis in FK866-treated Tumor Cells

(2013) Alessia Grozio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration

(2013) J. Graff et al.   JOURNAL OF NEUROSCIENCE

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

(2012) Ethan Hoffmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri

(2012) Xin Yu et al.   EXPERIMENTAL GERONTOLOGY

Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum

(2012) T. Genade et al.   EXPERIMENTAL GERONTOLOGY

Natural genetic variation in yeast longevity

(2012) S. W. Stumpferl et al.   GENOME RESEARCH

Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

(2012) Jill P. Crandall et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways

(2012) Yue Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

(2012) Vincenzo Libri et al.   PLoS One

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

(2012) Kushal Kr. Banerjee et al.   Cell Reports

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

(2011) Evi M. Mercken et al.   AGEING RESEARCH REVIEWS

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The high-resolution crystal structure of periplasmicHaemophilus influenzaeNAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

(2011) Silvia Garavaglia et al.   BIOCHEMICAL JOURNAL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

(2011) Gizem Rizki et al.   PLoS Genetics

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

(2010) Yu Wang et al.   FEBS LETTERS

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

Differential Effects of Resveratrol and SRT1720 on Lifespan of AdultCaenorhabditis elegans

(2010) K. Zarse et al.   HORMONE AND METABOLIC RESEARCH

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Turning enzymes ON with small molecules

(2010) Julie A Zorn et al.   Nature Chemical Biology

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

(2010) R.H.X. Wong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Caloric restriction: From soup to nuts

(2009) Stephen R. Spindler   AGEING RESEARCH REVIEWS

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

(2009) Kathryn Moynihan Ramsey et al.   AGING CELL

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants

(2009) Sang-Kyu Park et al.   AGING CELL

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

(2009) G Boily et al.   ONCOGENE

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

(2009) William Mair et al.   PLoS One

Xenohormesis: Sensing the Chemical Cues of Other Species

(2008) Konrad T. Howitz et al.   CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart

(2008) J.L. Barger et al.   EXPERIMENTAL GERONTOLOGY

Linking sirtuins, IGF-I signaling, and starvation

(2008) Valter D. Longo   EXPERIMENTAL GERONTOLOGY

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

(2008) Judit Pallos et al.   HUMAN MOLECULAR GENETICS

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

(2008) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression

(2007) Vladimir N. Ivanov et al.   EXPERIMENTAL CELL RESEARCH