The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1)

(2015) Ra Ham Lee et al.   DRUG DEVELOPMENT RESEARCH

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis

(2014) James H. Tabibian et al.   HEPATOLOGY

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

(2014) Rachel A. Gioscia-Ryan et al.   JOURNAL OF PHYSIOLOGY-LONDON

How tyrosine kinase inhibitors impair metabolism and endocrine system function: A systematic updated review

(2014) Massimo Breccia et al.   LEUKEMIA RESEARCH

Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice

(2013) Carolyn M. Roos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of mTOR Signaling by Quercetin in Cancer Treatment and Prevention

(2013) Ansgar Bruning   Anti-Cancer Agents in Medicinal Chemistry

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110δ subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors

(2013) Yan Xing et al.   LEUKEMIA RESEARCH

Targeting Plasminogen Activator Inhibitor-1 Inhibits Angiogenesis and Tumor Growth in a Human Cancer Xenograft Model

(2013) E. Gomes-Giacoia et al.   MOLECULAR CANCER THERAPEUTICS

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412

(2013) S Ståhl et al.   Cell Death & Disease

MiR-125b Inhibits Tumor Growth and Promotes Apoptosis of Cervical Cancer Cells by Targeting Phosphoinositide 3-Kinase Catalytic Subunit Delta

(2012) Fang Cui et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Translating advances from the basic biology of aging into clinical application

(2012) James L. Kirkland   EXPERIMENTAL GERONTOLOGY

Eph receptors and ephrins as targets for cancer therapy

(2012) Hong-Qing Xi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer

(2012) Sarat Chandarlapaty   Cancer Discovery

Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1

(2011) Siying Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

(2011) J. C. Montero et al.   CLINICAL CANCER RESEARCH

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2

(2011) M. Delhase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

(2010) Oanh N. L. Le et al.   AGING CELL

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells

(2010) Nélida C. Olave et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aging, Depot Origin, and Preadipocyte Gene Expression

(2010) Mark J. Cartwright et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dependence receptors: a new paradigm in cell signaling and cancer therapy

(2010) D Goldschneider et al.   ONCOGENE

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Interference With Netrin-1 and Tumor Cell Death in Non–Small Cell Lung Cancer

(2009) Céline Delloye-Bourgeois et al.   JNCI-Journal of the National Cancer Institute

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis

(2008) Céline Furne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer

(2008) Q Chang et al.   BRITISH JOURNAL OF CANCER

SerpinB2 Protection of Retinoblastoma Protein from Calpain Enhances Tumor Cell Survival

(2008) L. Tonnetti et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY