Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease

(2021) Gerald J. Shami et al.   Scientific Reports

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA–cGAS–STING Signaling Axis

(2021) Sylvia Torres-Odio et al.   JOURNAL OF IMMUNOLOGY

Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice

(2021) Jasvinder Singh Bhatti et al.   MITOCHONDRION

Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu

(2021) Ricardo P. Garay   EXPERT OPINION ON INVESTIGATIONAL DRUGS

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

(2021) Baback Roshanravan et al.   PLoS One

Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

(2020) Peivasteh Safarpour et al.   BMC Family Practice

[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis

(2020) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

(2020) María Luisa Castejón et al.   Antioxidants

The road ahead for health and lifespan interventions

(2020) Marta Gonzalez-Freire et al.   AGEING RESEARCH REVIEWS

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis

(2020) Joseph M. Salamoun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Moderation of mitochondrial respiration mitigates metabolic syndrome of aging

(2020) Mojdeh Tavallaie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy

(2020) Sergio Davinelli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

(2020) Stephanie J. Alexopoulos et al.   Nature Communications

Metformin and Its Benefits for Various Diseases

(2020) Ziquan Lv et al.   Frontiers in Endocrinology

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

(2020) Weiqi Hong et al.   Frontiers in Cell and Developmental Biology

Nicotinamide riboside—A missing piece in the puzzle of exercise therapy for older adults?

(2020) Carlo Custodero et al.   EXPERIMENTAL GERONTOLOGY

Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span

(2020) Michael B. Zemel   JOURNAL OF MEDICINAL FOOD

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

(2020) Jasvinder Singh Bhatti et al.   MOLECULAR NEUROBIOLOGY

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes

(2020) Sophie Hallakou‐Bozec et al.   DIABETES OBESITY & METABOLISM

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

(2019) Naohide Kanemoto et al.   Nature Communications

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia Via Promoting Glucose Oxidation

(2019) Haowen Jiang et al.   DIABETES

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

(2019) Leigh Goedeke et al.   Science Translational Medicine

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Dietary epicatechin, a novel anti-aging bioactive small molecule

(2019) Hongwei Si et al.   CURRENT MEDICINAL CHEMISTRY

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Lon in maintaining mitochondrial and endoplasmic reticulum homeostasis

(2018) Jieyeqi Yang et al.   ARCHIVES OF TOXICOLOGY

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

(2018) Charles S. Dela Cruz et al.   MITOCHONDRION

Molecular structural diversity of mitochondrial cardiolipins

(2018) Gregor Oemer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

(2018) Megan M. Senchuk et al.   PLoS Genetics

Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations

(2018) Andrea Stoccoro et al.   Epigenomics

The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes

(2018) Irene Escribano-Lopez et al.   Scientific Reports

Mitochondrial quality control as a key determinant of cell survival

(2018) Lucia Sedlackova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue

(2018) Rosario Pardo et al.   FASEB JOURNAL

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender

(2018) Cristiana Porcu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation

(2017) Audrey Lafargue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome

(2017) Stephanie E Siegmund et al.   HUMAN MOLECULAR GENETICS

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm

(2017) Aakanksha Jain et al.   JOURNAL OF IMMUNOLOGY

Significance of Resveratrol in Clinical Management of Chronic Diseases

(2017) Awais Wahab et al.   MOLECULES

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress

(2017) C. Binsch et al.   Molecular Metabolism

Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus

(2017) Shipra Bhansali et al.   Frontiers in Endocrinology

The Oxygen Paradox, the French Paradox, and age-related diseases

(2017) Joanna M. S. Davies et al.   GeroScience

Quantification of global mitochondrial DNA methylation levels and inverse correlation with age at two CpG sites

(2016) Shakhawan K. Mawlood et al.   Aging-US

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

(2016) Marta Blanch et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity

(2016) Rainey E. Patterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nutrient sensing and utilization: Getting to the heart of metabolic flexibility

(2016) Timothy M. Griffin et al.   BIOCHIMIE

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Targeting Mitochondria in Cardiovascular Diseases

(2016) Filomena Silva et al.   CURRENT PHARMACEUTICAL DESIGN

Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging

(2016) Elisa Fabbri et al.   DIABETES

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic syndrome and risk of major coronary events among the urban diabetic patients: North Indian Diabetes and Cardiovascular Disease Study—NIDCVD-2

(2016) Gurjit Kaur Bhatti et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

A novel mutation m.8561C>G in MT-ATP6/8 causing a mitochondrial syndrome with ataxia, peripheral neuropathy, diabetes mellitus, and hypergonadotropic hypogonadism

(2016) Laura Kytövuori et al.   JOURNAL OF NEUROLOGY

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

(2016) N. S. Morsci et al.   JOURNAL OF NEUROSCIENCE

Calorie restriction as an intervention in ageing

(2016) Guillermo López-Lluch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

(2016) Luca Valenti et al.   LIVER INTERNATIONAL

Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions

(2016) Jun Peng et al.   MITOCHONDRION

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

(2016) Melissa F. Brereton et al.   Nature Communications

FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

(2016) Ineke Dhondt et al.   Cell Reports

NAMPT-Mediated NAD + Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

(2016) Kelly L. Stromsdorfer et al.   Cell Reports

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Mitochondrial proteases and protein quality control in ageing and longevity

(2015) Marie-Paule Hamon et al.   AGEING RESEARCH REVIEWS

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans

(2015) Stefano Ciciliot et al.   DIABETOLOGIA

Mitochondrial disease in adults: what's old and what's new?

(2015) P. F. Chinnery   EMBO Molecular Medicine

Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study

(2015) Bram G Janssen et al.   Epigenetics

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors

(2015) Bernd Bufe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

(2015) Christal D. Sohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans

(2015) Louise D. Zheng et al.   Clinical Epigenetics

Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease

(2015) Andrea A Baccarelli et al.   Clinical Epigenetics

p66Shc-induced redox changes drive endothelial insulin resistance

(2014) Francesco Paneni et al.   ATHEROSCLEROSIS

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

(2014) Morten Scheibye-Knudsen et al.   Autophagy

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

(2014) Arun Baksi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Roles of mitochondrial ubiquitin ligase MITOL/MARCH5 in mitochondrial dynamics and diseases

(2014) S. Nagashima et al.   JOURNAL OF BIOCHEMISTRY

The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality

(2014) Margalit Goldgof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluating the number of mitochondrial DNA copies in leukocytes and adipocytes from metabolic syndrome patients: Pilot study

(2014) O. I. Mozhey et al.   MOLECULAR BIOLOGY

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study

(2014) R. Cooper et al.   BMJ-British Medical Journal

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Changes of mitochondria in atherosclerosis: Possible determinant in the pathogenesis of the disease

(2013) Igor A. Sobenin et al.   ATHEROSCLEROSIS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

(2013) Y.-Y. Fu et al.   DIABETOLOGIA

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern

(2013) D. Bellizzi et al.   DNA RESEARCH

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

(2013) S. Gispert et al.   HUMAN MOLECULAR GENETICS

Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging

(2013) Matthias Oelze et al.   HYPERTENSION

Mitochondrial DNA mutations and essential hypertension (Review)

(2013) YU DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes

(2013) Soo Jin Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A novel heteroplasmic mitochondrial DNA mutation, A8890G, in a patient with juvenile-onset metabolic syndrome: A case report

(2013) WEI YE et al.   Molecular Medicine Reports

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice

(2013) James Lester Figarola et al.   PLoS One

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

(2012) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Fatty Acid Oxidation in Obesity

(2012) Dolors Serra et al.   ANTIOXIDANTS & REDOX SIGNALING

Chaperone–protease networks in mitochondrial protein homeostasis

(2012) Wolfgang Voos   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence

(2012) Hae-Ok Byun et al.   EXPERIMENTAL CELL RESEARCH

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells Do Not Require Glycolysis and Are Not Initiated by Fluctuations in Mitochondrial Bioenergetics

(2012) Isabel Goehring et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

(2012) Santhosh Satapati et al.   JOURNAL OF LIPID RESEARCH

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro

(2012) M. F. Lodeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mortality improvement in evolutionary context

(2012) O. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice

(2011) Holly M. Brown-Borg et al.   AGE

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

(2011) Thomas Koeck et al.   Cell Metabolism

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

(2011) Carlo Viscomi et al.   Cell Metabolism

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

(2011) Pam R. Taub et al.   CTS-Clinical and Translational Science

Calorie restriction and prevention of age-associated chronic disease

(2011) Daniela Omodei et al.   FEBS LETTERS

Preservation of β-Cell Function: The Key to Diabetes Prevention

(2011) Ralph A. DeFronzo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men

(2011) Marika Leenders et al.   JOURNAL OF NUTRITION

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

(2011) Brendan A I Payne et al.   NATURE GENETICS

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

(2010) Agnieszka A. Kendrick et al.   BIOCHEMICAL JOURNAL

Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes

(2010) Agnieszka Biala et al.   BLOOD PRESSURE

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

(2010) Kristel Brys et al.   BMC BIOLOGY

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

(2010) Ines Pagel-Langenickel et al.   ENDOCRINE REVIEWS

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

A Mitochondria-Targeted Vitamin E Derivative Decreases Hepatic Oxidative Stress and Inhibits Fat Deposition in Mice

(2010) Gaowei Mao et al.   JOURNAL OF NUTRITION

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

(2010) Vittoria Infantino et al.   MOLECULAR GENETICS AND METABOLISM

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

T16189C mitochondrial DNA variant is associated with metabolic syndrome in Caucasian subjects

(2010) Vincenzo Ostilio Palmieri et al.   NUTRITION

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial dysfunction and lipotoxicity

(2009) Patrick Schrauwen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Coronary Aging in HIV‐Infected Patients

(2009) Giovanni Guaraldi et al.   CLINICAL INFECTIOUS DISEASES

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations?

(2009) R. S Bhopal et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1  in Long-Lived Mclk1+/- Mouse Mutants

(2009) D. Wang et al.   JOURNAL OF IMMUNOLOGY

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

(2009) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities

(2008) Shane R. Thomas et al.   ANTIOXIDANTS & REDOX SIGNALING

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

(2008) E. Phielix et al.   DIABETES

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

(2008) João S. Teodoro et al.   MITOCHONDRION

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA mutations and aging: devils in the details?

(2008) Konstantin Khrapko et al.   TRENDS IN GENETICS