Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

(2021) Ramu Manjula et al.   Frontiers in Pharmacology

SIRT7: a sentinel of genome stability

(2021) Ming Tang et al.   Open Biology

The Influence of Epigenetic Modifications on Metabolic Changes in White Adipose Tissue and Liver and Their Potential Impact in Exercise

(2021) Jessie E. Axsom et al.   Frontiers in Physiology

Review: The plant sirtuins

(2020) Weiping Zheng   PLANT SCIENCE

Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer

(2020) Daniela Tomaselli et al.   Frontiers in Oncology

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

(2020) Fangzhou Jiao et al.   Oxidative Medicine and Cellular Longevity

Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease

(2020) Swapnil Raj et al.   Frontiers in Pharmacology

Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice

(2019) Qianqian Liu et al.   BEHAVIOURAL BRAIN RESEARCH

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

(2019) Khatia Gabisonia et al.   NATURE

Cardioprotective Heme Oxygenase‐1‐PGC1α Signaling in Epicardial Fat Attenuates Cardiovascular Risk in Humans as in Obese Mice

(2019) Shailendra P. Singh et al.   Obesity

Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span

(2019) Do Hee Kim et al.   PLoS One

Sirtuins in Multiple Sclerosis: The crossroad of neurodegeneration, autoimmunity and metabolism

(2019) Forough Foolad et al.   Multiple Sclerosis and Related Disorders

Circuit Mechanisms of Neurodegenerative Diseases: A New Frontier With Miniature Fluorescence Microscopy

(2019) Craig T. Werner et al.   Frontiers in Neuroscience

Insights into the molecular regulation of monolignol-derived product biosynthesis in the growing hemp hypocotyl

(2018) Marc Behr et al.   BMC PLANT BIOLOGY

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology

(2018) Surinder Kumar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy

(2018) Sang-Won Min et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β Increases Tau by Mediating Sirtuin 3 in Alzheimer’s Disease

(2018) Junxiang Yin et al.   MOLECULAR NEUROBIOLOGY

The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure

(2018) Satoru Yanagisawa et al.   PLoS One

Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster

(2018) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of SIRT3 in the Brain Under Physiological and Pathological Conditions

(2018) Elena Sidorova-Darmos et al.   Frontiers in Cellular Neuroscience

Key proteins and pathways that regulate lifespan

(2017) Haihui Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

(2017) Luana Naia et al.   JOURNAL OF NEUROSCIENCE

Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)

(2017) James Boslett et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis

(2017) Adam Khader et al.   JOURNAL OF SURGICAL RESEARCH

Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway

(2017) Hongyan Li et al.   LIFE SCIENCES

Acetylome Profiling Reveals Extensive Lysine Acetylation of the Fatty Acid Metabolism Pathway in the DiatomPhaeodactylum tricornutum

(2017) Zhuo Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Correction for Papa and Germain, “SirT3 Regulates a Novel Arm of the Mitochondrial Unfolded Protein Response”

(2017) Luena Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders

(2017) J. Motyl et al.   MOLECULAR NEUROBIOLOGY

Safety Aspects of the Use of Quercetin as a Dietary Supplement

(2017) Susanne Andres et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis

(2017) Xiaoyun Liu et al.   Molecular Plant

CSF biomarkers for Alzheimer disease — approaching consensus

(2017) Douglas R. Galasko et al.   Nature Reviews Neurology

SIRT3 and mitochondrial metabolism in neurodegenerative diseases

(2017) Illari Salvatori et al.   NEUROCHEMISTRY INTERNATIONAL

Rice NAD+-dependent histone deacetylase OsSRT1 represses glycolysis and regulates the moonlighting function of GAPDH as a transcriptional activator of glycolytic genes

(2017) Hua Zhang et al.   NUCLEIC ACIDS RESEARCH

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

(2017) Martin Pannek et al.   Nature Communications

Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans

(2017) Hongdou Luo et al.   Frontiers in Aging Neuroscience

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

(2017) Rita Machado de Oliveira et al.   PLOS BIOLOGY

Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster

(2017) Yasunari Kayashima et al.   Scientific Reports

Sirtuins: not only animal proteins

(2016) I. Szućko   ACTA PHYSIOLOGIAE PLANTARUM

The role of sirtuins in aging and age-related diseases

(2016) Mateusz Wątroba et al.   Advances in Medical Sciences

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

(2016) Xiaonan Wang et al.   BRAIN RESEARCH

Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling

(2016) Yanping Miao et al.   BRAIN RESEARCH BULLETIN

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

The role of mitochondrial sirtuins in health and disease

(2016) Brenna Osborne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role ofSirt3in mitochondrial biogenesis and developmental competence of humanin vitromatured oocytes

(2016) Hong-Cui Zhao et al.   HUMAN REPRODUCTION

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

(2016) Gloria Biella et al.   JOURNAL OF ALZHEIMERS DISEASE

Sirtuins as modifiers of Parkinson's disease pathology

(2016) Bor Luen Tang   JOURNAL OF NEUROSCIENCE RESEARCH

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

(2016) Henryk Jęśko et al.   NEUROCHEMICAL RESEARCH

Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons

(2016) Johanna Mäkelä et al.   NEUROPHARMACOLOGY

Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer

(2016) GUOYU HUANG et al.   ONCOLOGY REPORTS

OsSRT1 is involved in rice seed development through regulation of starch metabolism gene expression

(2016) Hua Zhang et al.   PLANT SCIENCE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

(2016) Koichi Hasegawa et al.   Nature Communications

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

Enhancing NAD+salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease

(2016) Susann Lehmann et al.   Biology Open

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease

(2015) Lei Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Sirtuin regulation in aging and injury

(2015) Ninu Poulose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tumour-suppressive function of SIRT4 in human colorectal cancer

(2015) M Miyo et al.   BRITISH JOURNAL OF CANCER

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

(2015) K. Rajasekhar et al.   CHEMICAL COMMUNICATIONS

Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively

(2015) Qi-Lin Wang et al.   CHINESE MEDICAL JOURNAL

The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia

(2015) Frank M. Sacks   CURRENT OPINION IN LIPIDOLOGY

Systems biology of neurodegenerative diseases

(2015) Levi B. Wood et al.   Integrative Biology

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global and Specific Responses of the Histone Acetylome to Systematic Perturbation

(2015) Christian Feller et al.   MOLECULAR CELL

Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer’s Disease

(2015) Wenxiu Yang et al.   NEUROCHEMICAL RESEARCH

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

(2015) Emily Jane Gallagher et al.   PHYSIOLOGICAL REVIEWS

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Differential expression of sirtuins in the aging rat brain

(2015) Nady Braidy et al.   Frontiers in Cellular Neuroscience

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

(2014) Judith Eschbach et al.   ANNALS OF NEUROLOGY

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis

(2014) Wenzhi Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

(2014) Sungki Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DrosophilaSirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

(2014) Motiur Rahman et al.   JOURNAL OF CELL BIOLOGY

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

(2014) A. V. Witte et al.   JOURNAL OF NEUROSCIENCE

Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

(2014) Jun Fan et al.   MOLECULAR CELL

The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer’s Disease: A Meta-analysis

(2014) Wenjin Wei et al.   NEUROMOLECULAR MEDICINE

Expectation mismatch: Differences between self-generated and cue-induced expectations

(2014) R. Gaschler et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

SIRT6 Is Required for Normal Retinal Function

(2014) Dafne M. Silberman et al.   PLoS One

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Systemic regulation of mammalian ageing and longevity by brain sirtuins

(2014) Akiko Satoh et al.   Nature Communications

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

(2013) Y. Ren et al.   Animal

The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock

(2013) Jérôme Lugrin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

Targeting Sirtuin-1 in Huntington’s Disease: Rationale and Current Status

(2013) Wenzhen Duan   CNS DRUGS

SIRT1 and SIRT2: emerging targets in neurodegeneration

(2013) Gizem Donmez et al.   EMBO Molecular Medicine

Dexamethasone influences FGF-induced responses in lens epithelial explants and promotes the posterior capsule coverage that is a feature of glucocorticoid-induced cataract

(2013) Chunxiao Wang et al.   EXPERIMENTAL EYE RESEARCH

Yeast sirtuins and the regulation of aging

(2013) Margaret B. Wierman et al.   FEMS YEAST RESEARCH

Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1–42)-induced rat model of Alzheimer's disease

(2013) E. Turunc Bayrakdar et al.   FREE RADICAL RESEARCH

Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets

(2013) V. K. Nimmagadda et al.   JOURNAL OF IMMUNOLOGY

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

(2013) Catia C. Proenca et al.   PLoS One

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

The role of sirtuins in Alzheimer's disease

(2013) Rakhee Lalla et al.   Frontiers in Aging Neuroscience

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers

(2013) Sowmya Venkatasubramanian et al.   Journal of the American Heart Association

Potential role of sirtuins in livestock production

(2012) Y. Ghinis-Hozumi et al.   Animal

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

Drosophila melanogaster in the Study of Human Neurodegeneration

(2012) Frank Hirth   CNS & Neurological Disorders-Drug Targets

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Mitochondrial sirtuins - a new therapeutic target for repair and protection in multiple sclerosis

(2012) C. M. Rice et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells

(2012) Tomohiro Kozako et al.   INTERNATIONAL JOURNAL OF CANCER

trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

(2012) Jinrong Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Protects against  -Synuclein Aggregation by Activating Molecular Chaperones

(2012) G. Donmez et al.   JOURNAL OF NEUROSCIENCE

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

(2012) Gaoxiang Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization and differential expression analysis of complete coding sequences of Vitis vinifera L. sirtuin genes

(2012) M. Cucurachi et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

(2012) Vincenzo Libri et al.   PLoS One

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

The neurobiology of sirtuins and their role in neurodegeneration

(2012) Gizem Donmez   TRENDS IN PHARMACOLOGICAL SCIENCES

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

(2012) Kushal Kr. Banerjee et al.   Cell Reports

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

SIRT2 activity is required for the survival of C6 glioma cells

(2011) Xin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

Advances in porcine genomics and proteomics--a toolbox for developing the pig as a model organism for molecular biomedical research

(2011) E. Bendixen et al.   Briefings in Functional Genomics

Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network

(2011) V. Audrito et al.   CANCER RESEARCH

Effects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts

(2011) Yang Baohua et al.   CELL BIOLOGY INTERNATIONAL

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Cellular and molecular effects of sirtuins in health and disease

(2011) Yoshiyuki Horio et al.   CLINICAL SCIENCE

Bioenergetic dysfunction in Huntington's disease human cybrids

(2011) I. Luisa Ferreira et al.   EXPERIMENTAL NEUROLOGY

Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

(2011) Guangbo Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells

(2011) Ke Long Jin et al.   Journal of Gynecologic Oncology

Biological role of lutein in the light-induced retinal degeneration

(2011) Mariko Sasaki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver

(2011) Helena Schirmer et al.   MOLECULAR BIOLOGY REPORTS

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction

(2011) Albert Giralt et al.   Molecular Neurodegeneration

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial dysfunction in ALS

(2011) Mauro Cozzolino et al.   PROGRESS IN NEUROBIOLOGY

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Zebrafish as a Model Organism to Evaluate Drugs Potentially Able to Modulate Sirtuin Expression

(2011) Talita Carneiro Brandão Pereira et al.   Zebrafish

Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease

(2011) Jake G Hoekstra et al.   Alzheimers Research & Therapy

Ageing and neurodegenerative diseases

(2010) Chia-Wei Hung et al.   AGEING RESEARCH REVIEWS

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Mitochondria and Huntington's Disease Pathogenesis

(2010) Susan E. Browne   Annals of the New York Academy of Sciences

Sirtuin activators: Designing molecules to extend life span

(2010) Antoni Camins et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

(2010) Sergio E. Baranzini et al.   BRAIN

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

dSir2 and longevity in Drosophila

(2010) Stewart Frankel et al.   EXPERIMENTAL GERONTOLOGY

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

(2010) Daniel J. Ho et al.   EXPERIMENTAL NEUROLOGY

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2010) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis

(2010) DAVID C. NIEMAN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

(2010) Chi-Hsien Peng et al.   SENSORS

Anti-aging herbal medicine—How and why can they be used in aging-associated neurodegenerative diseases?

(2009) Yuen-Shan Ho et al.   AGEING RESEARCH REVIEWS

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

(2009) J. Mark Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Function of Sirtuins in Biological Tissues

(2009) Balaji Shoba et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Sirtuin inhibitors

(2009) Francisco J Alcaín et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sirtuin activators

(2009) Francisco J Alcaín et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Subcellular localization of rice histone deacetylases in organelles

(2009) Pil Joong Chung et al.   FEBS LETTERS

Drosophila melanogaster as a Model Organism of Brain Diseases

(2009) Astrid Jeibmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nicotinic Acid-Mediated Activation of Both Membrane and Nuclear Receptors towards Therapeutic Glucocorticoid Mimetics for Treating Multiple Sclerosis

(2009) W. Todd Penberthy   PPAR Research

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

(2008) Keitaro Kojima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

Therapeutic role of sirtuins in neurodegenerative disease

(2008) Tiago Fleming Outeiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free-Energy Calculations, and Biological Testing

(2008) Urszula Uciechowska et al.   ChemMedChem

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast

(2008) E. Easlon et al.   GENES & DEVELOPMENT

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

(2008) Judit Pallos et al.   HUMAN MOLECULAR GENETICS

Porcine sirtuin 1 gene clone, expression pattern, and regulation by resveratrol1

(2008) T. Shan et al.   JOURNAL OF ANIMAL SCIENCE

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

(2008) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode

(2008) Robert C. Neugebauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE

Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila

(2008) A. J. Griswold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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