YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

(2021) Guilherme Pedreira de Freitas Nader et al.   CELL

Aged skeletal stem cells generate an inflammatory degenerative niche

(2021) Thomas H. Ambrosi et al.   NATURE

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

The aging skin microenvironment dictates stem cell behavior

(2020) Yejing Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

(2020) Gururaj Rao Kidiyoor et al.   Nature Communications

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

(2020) Tracy A Bedrosian et al.   EMBO JOURNAL

Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the ‘tissue skeleton’ gene network as a component of skin chrono-ageing

(2019) Valérie Haydont et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

YAP1‐LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

(2019) Chunbo He et al.   EMBO REPORTS

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease

(2019) Melanie Maurer et al.   Annual Review of Biomedical Engineering

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

(2019) Antonio Totaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing

(2019) Salah Mahmoudi et al.   NATURE

The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging

(2019) Collin Yvès Ewald   GERONTOLOGY

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence

(2018) Giulia Santinon et al.   EMBO JOURNAL

Aortic dilatation in Marfan syndrome

(2018) Paolo Salvi et al.   JOURNAL OF HYPERTENSION

Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility

(2018) Valérie Haydont et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

(2018) Marion Claudia Salzer et al.   CELL

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

(2017) Jeong-Ki Kim et al.   Nature Communications

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

(2017) Antonio Totaro et al.   Nature Communications

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

(2016) Tito Panciera et al.   Cell Stem Cell

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Comparison of mice with accelerated aging caused by distinct mechanisms

(2015) Aditi U. Gurkar et al.   EXPERIMENTAL GERONTOLOGY

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

(2015) Daniel M. Waldera Lupa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

(2015) Gerhard Sengle et al.   MATRIX BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

The hallmarks of fibroblast ageing

(2014) Julia Tigges et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Dysfunctional Mechanosensing in Aneurysms

(2014) J. D. Humphrey et al.   SCIENCE

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

(2013) F Fausti et al.   CELL DEATH AND DIFFERENTIATION

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

(2013) Oliver Dreesen et al.   JOURNAL OF CELL BIOLOGY

Inhibitory signalling to the Arp2/3 complex steers cell migration

(2013) Irene Dang et al.   NATURE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Negative control of Smad activity by ectodermin/Tif1  patterns the mammalian embryo

(2010) L. Morsut et al.   DEVELOPMENT

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Looking Older

(2008) Gary J. Fisher et al.   ARCHIVES OF DERMATOLOGY