The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

(2021) Kristen R. Maynard et al.   NATURE NEUROSCIENCE

Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis

(2021) Won-Min Song et al.   Nature Communications

Inference and analysis of cell-cell communication using CellChat

(2021) Suoqin Jin et al.   Nature Communications

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

(2021) Ines Sturmlechner et al.   SCIENCE

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

(2020) Tamas Kiss et al.   GeroScience

AP-1 imprints a reversible transcriptional programme of senescent cells

(2020) Ricardo Iván Martínez-Zamudio et al.   NATURE CELL BIOLOGY

The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects

(2020) Yogesh Saini et al.   Cancers

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease

(2020) Annie G. Bryant et al.   Frontiers in Neurology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

(2020) Minghui Wang et al.   NEURON

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence

(2019) Kasit Chatsirisupachai et al.   AGING CELL

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease

(2019) Qian Wang et al.   Nature Communications

Insights into replicative senescence of human testicular peritubular cells

(2019) Nina Schmid et al.   Scientific Reports

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

The adult human testis transcriptional cell atlas

(2018) Jingtao Guo et al.   CELL RESEARCH

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Techniques to Induce and Quantify Cellular Senescence

(2017) Nicole Noren Hooten et al.   Jove-Journal of Visualized Experiments

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence

(2016) Crystal A. Tonnessen-Murray et al.   Cold Spring Harbor Perspectives in Medicine

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Multiscale Embedded Gene Co-expression Network Analysis

(2015) Won-Min Song et al.   PLoS Computational Biology

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence

(2013) H. Cui et al.   CANCER RESEARCH

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality

(2013) Seong-Jun Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells

(2010) Kyoung Eun Lee et al.   CANCER CELL

p53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase

(2010) M. Zemskova et al.   MOLECULAR CANCER RESEARCH

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

ING1a expression increases during replicative senescence and induces a senescent phenotype

(2008) Mohamed A. Soliman et al.   AGING CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Interferon Regulatory Factors IRF5 and IRF7 Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts

(2008) Q. Li et al.   MOLECULAR CANCER RESEARCH

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY