IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms−

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

(2020) Liam D. Cassidy et al.   Nature Communications

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Puncta intended: connecting the dots between autophagy and cell stress networks

(2020) Cally J. Ho et al.   Autophagy

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy

(2020) Juliette Humeau et al.   Cell Death & Disease

Hallmarks of Health

(2020) Carlos López-Otín et al.   CELL

Autophagy-mediated metabolic effects of aspirin

(2020) Francesca Castoldi et al.   Cell Death Discovery

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective

(2019) Giovanni Vitale et al.   Frontiers in Endocrinology

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

(2019) Yihua Wang et al.   Autophagy

Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer

(2019) Thomas B. Karasic et al.   JAMA Oncology

A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

(2019) Sarah Lévesque et al.   OncoImmunology

A discovery platform for the identification of caloric restriction mimetics with broad health-improving effects

(2019) Oliver Kepp et al.   Autophagy

3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE 3 and TFEB

(2019) Guo Chen et al.   EMBO Molecular Medicine

Growth factors stimulate anabolic metabolism by directing nutrient uptake

(2019) Craig B. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study

(2019) Margaret von Mehren et al.   CLINICAL CANCER RESEARCH

eIF2α phosphorylation is pathognomonic for immunogenic cell death

(2018) Lucillia Bezu et al.   CELL DEATH AND DIFFERENTIATION

Phase 2 study evaluating intermittent and continuous linsitinib and weekly paclitaxel in patients with recurrent platinum resistant ovarian epithelial cancer

(2018) Amit Oza et al.   GYNECOLOGIC ONCOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

A Phase I Dose‐Escalation Study of Linsitinib (OSI‐906), a Small‐Molecule Dual Insulin‐Like Growth Factor‐1 Receptor/Insulin Receptor Kinase Inhibitor, in Combination with Irinotecan in Patients with Advanced Cancer

(2018) S. Lindsey Davis et al.   ONCOLOGIST

TumGrowth: An open-access web tool for the statistical analysis of tumor growth curves

(2018) David P. Enot et al.   OncoImmunology

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

(2018) Kristina B. Emdal et al.   Science Signaling

Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial

(2017) Marta Schirripa et al.   INTERNATIONAL JOURNAL OF CANCER

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

(2017) Graeme Hewitt et al.   TRENDS IN CELL BIOLOGY

Phase II randomized study of the IGF-1R pathway modulator AXL1717 compared to docetaxel in patients with previously treated, locally advanced or metastatic non-small cell lung cancer

(2016) Michael Bergqvist et al.   ACTA ONCOLOGICA

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

(2016) Sylvain Ladoire et al.   Autophagy

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors

(2016) V. M. Macaulay et al.   CLINICAL CANCER RESEARCH

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer

(2015) Sylvain Ladoire et al.   Autophagy

Cellular adaptation to nutrient deprivation: crosstalk between the mTORC1 and eIF2α signaling pathways and implications for autophagy

(2015) Jordan C Wengrod et al.   CELL CYCLE

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study

(2015) Martin Fassnacht et al.   LANCET ONCOLOGY

Quantification of cellular viability by automated microscopy and flow cytometry

(2015) Allan Sauvat et al.   Oncotarget

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

(2014) R. L. Jones et al.   CLINICAL CANCER RESEARCH

A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer

(2014) Johanna C. Bendell et al.   INVESTIGATIONAL NEW DRUGS

IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples

(2014) Frency Varghese et al.   PLoS One

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

(2013) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Starvation, detoxification, and multidrug resistance in cancer therapy

(2012) Changhan Lee et al.   DRUG RESISTANCE UPDATES

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

(2011) Rodrigo Troncoso et al.   CARDIOVASCULAR RESEARCH

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

(2010) N Berndt et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Clinical Significance of Insulin-Like Growth Factor Type 1 Receptor and Epidermal Growth Factor Receptor in Patients with Advanced Gastric Cancer

(2008) Junichi Matsubara et al.   ONCOLOGY