The antagonistic pleiotropy of insulin‐like growth factor 1

Genetics of 35 blood and urine biomarkers in the UK Biobank

(2021) Nasa Sinnott-Armstrong et al.   NATURE GENETICS

Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways

(2020) Md. Abdul Alim Al‐Bari et al.   Annals of the New York Academy of Sciences

Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults

(2020) William B. Zhang et al.   Cells

IGF-1 and cardiometabolic diseases: a Mendelian randomisation study

(2020) Susanna C. Larsson et al.   DIABETOLOGIA

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

(2019) Gabriela E. Farias Quipildor et al.   GeroScience

Identifying dementia cases with routinely collected health data: A systematic review

(2018) Tim Wilkinson et al.   Alzheimers & Dementia

40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain

(2018) Sriram Gubbi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

(2018) Kai Mao et al.   Nature Communications

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

(2018) Sreemathi Logan et al.   Molecular Metabolism

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research

(2016) Sofiya Milman et al.   Cell Metabolism

Fifty seven years of follow-up of the Israeli cohort of Laron Syndrome patients—From discovery to treatment

(2016) Zvi Laron et al.   GROWTH HORMONE & IGF RESEARCH

Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

(2016) Olga Spadaro et al.   Cell Reports

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

(2015) Evie van der Spoel et al.   Aging-US

Impact of Age-Adjusted Insulin-Like Growth Factor 1 on Major Cardiovascular Events After Acute Myocardial Infarction: Results From the Fast-MI Registry

(2015) Olivier Bourron et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men

(2012) Johan Svensson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin-Like Growth Factors and Insulin: At the Crossroad Between Tumor Development and Longevity

(2012) R. Novosyadlyy et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

(2011) Rodrigo Troncoso et al.   CARDIOVASCULAR RESEARCH

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Meta-Analysis and Dose-Response Metaregression: Circulating Insulin-Like Growth Factor I (IGF-I) and Mortality

(2011) Anne Marij G. Burgers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

Mortality and Serum Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein 3 Concentrations

(2009) Nele Friedrich et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

(2009) Y. Ikeno et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population

(2008) Mikkel Andreassen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL