The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk

Tobacco smoking and somatic mutations in human bronchial epithelium

(2020) Kenichi Yoshida et al.   NATURE

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice

(2020) Yun Rose Li et al.   Nature Communications

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

Capturing the primordial Kras mutation initiating urethane carcinogenesis

(2020) Siqi Li et al.   Nature Communications

The mutational signature profile of known and suspected human carcinogens in mice

(2020) Laura Riva et al.   NATURE GENETICS

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis

(2019) Soo Ki Kim et al.   JOURNAL OF GASTROENTEROLOGY

FXR Regulates Intestinal Cancer Stem Cell Proliferation

(2019) Ting Fu et al.   CELL

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia

(2019) Christine M. McMahon et al.   Cancer Discovery

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver

(2019) Simon F. Brunner et al.   NATURE

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Cellular survival over genomic perfection

(2019) Serena Nik-Zainal et al.   SCIENCE

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

(2018) Jesse J. Salk et al.   NATURE REVIEWS GENETICS

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

(2018) Kazuaki Suda et al.   Cell Reports

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Recurrent acute thermal lesion induces esophageal hyperproliferative premalignant lesions in mice esophagus

(2016) D.C.M. Rapozo et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Substantial contribution of extrinsic risk factors to cancer development

(2015) Song Wu et al.   NATURE

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers

(2015) Melissa Q McCreery et al.   NATURE MEDICINE

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

(2015) Dany Nassar et al.   NATURE MEDICINE

Cancer risk: Role of chance overstated

(2015) C. Wild et al.   SCIENCE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers

(2014) Courtney Schaal et al.   MOLECULAR CANCER RESEARCH

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE