MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test

(2020) Xinqiang Yin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice

(2020) Yin Xinqiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Internalization mechanisms of cell-penetrating peptides

(2020) Ivana Ruseska et al.   Beilstein Journal of Nanotechnology

Mitochondria as intracellular signaling platforms in health and disease

(2020) Jay X. Tan et al.   JOURNAL OF CELL BIOLOGY

MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction

(2019) Huanyu Lu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

(2019) Bérénice A. Benayoun et al.   GENOME RESEARCH

Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c

(2019) Qingyang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipids and insulin regulate mitochondrial‐derived peptide (MOTS‐c) in PCOS and healthy subjects

(2019) Manjunath Ramanjaneya et al.   CLINICAL ENDOCRINOLOGY

Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation

(2019) Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects

(2019) Manjunath Ramanjaneya et al.   Frontiers in Endocrinology

MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation

(2019) Zhao Yan et al.   PHARMACOLOGICAL RESEARCH

Enabling Healthful Aging for All — The National Academy of Medicine Grand Challenge in Healthy Longevity

(2019) Victor J. Dzau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitocellular communication: Shaping health and disease

(2019) Adrienne Mottis et al.   SCIENCE

Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

(2019) Ming Wei et al.   CardioRenal Medicine

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

(2018) Kyung Hwa Kim et al.   Cell Metabolism

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

(2018) Luis Rodrigo Cataldo et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

(2018) Caiqi Du et al.   PEDIATRIC DIABETES

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

(2018) Kai Mao et al.   Nature Communications

Synthetic molecular evolution of hybrid cell penetrating peptides

(2018) W. Berkeley Kauffman et al.   Nature Communications

Mitochondria are physiologically maintained at close to 50 °C

(2018) Dominique Chrétien et al.   PLOS BIOLOGY

A Mitochondrial-Derived Peptide Exercises the Nuclear Option

(2018) Kailash C. Mangalhara et al.   Cell Metabolism

From Lifespan to Healthspan

(2018) S. Jay Olshansky   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aging as a Biological Target for Prevention and Therapy

(2018) Nir Barzilai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

A Mitochondrial Encoded Messenger at the Nucleus

(2018) Cheryl Yong et al.   Cells

Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men.

(2018) Christopher Paul Hedges et al.   JOURNAL OF APPLIED PHYSIOLOGY

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Development of a mass spectrometry-based detection method for the mitochondrion-derived peptide MOTS-c in plasma samples for doping control purposes

(2018) A. Knoop et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Mitochondrially derived peptides as novel regulators of metabolism

(2017) Su-Jeong Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Business of Anti-Aging Science

(2017) João Pedro de Magalhães et al.   TRENDS IN BIOTECHNOLOGY

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

Rethinking HSF1 in Stress, Development, and Organismal Health

(2017) Jian Li et al.   TRENDS IN CELL BIOLOGY

Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation

(2016) Wei Ming et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

(2016) Matthijs K. C. Hesselink et al.   Nature Reviews Endocrinology

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

(2015) Noriyuki Fuku et al.   AGING CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance

(2015) Kim Zarse et al.   Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

The role of mitochondrial derived peptides (MDPs) in metabolism

(2015) Rafael Alis et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Healthy aging: The ultimate preventative medicine

(2015) M. Kaeberlein et al.   SCIENCE

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Exercise Pills: At the Starting Line

(2015) Shunchang Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

The Demographic and Biomedical Case for Late-Life Interventions in Aging

(2010) M. J. Rae et al.   Science Translational Medicine

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Free radicals and exercise: An introduction

(2007) Lester Packer et al.   FREE RADICAL BIOLOGY AND MEDICINE