A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Authors
Keywords
-
Journal
Science Translational Medicine
Volume 13, Issue 575, Pages eabd2655
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-01-07
DOI
10.1126/scitranslmed.abd2655
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The ageing epigenome and its rejuvenation
- (2020) Weiqi Zhang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
- (2020) Yusheng Cai et al. CELL RESEARCH
- Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
- (2020) Chuqian Liang et al. CELL RESEARCH
- A Single-Cell Transcriptomic Atlas of Human Skin Aging
- (2020) Zhiran Zou et al. DEVELOPMENTAL CELL
- Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence
- (2019) Payel Sen et al. MOLECULAR CELL
- The Genetics of Aging: A Vertebrate Perspective
- (2019) Param Priya Singh et al. CELL
- The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis
- (2019) Alkistis-Maria Papatheodoridi et al. HEPATOLOGY
- A single combination gene therapy treats multiple age-related diseases
- (2019) Noah Davidsohn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HBO1 is required for the maintenance of leukaemia stem cells
- (2019) Laura MacPherson et al. NATURE
- Senescent cell turnover slows with age providing an explanation for the Gompertz law
- (2019) Omer Karin et al. Nature Communications
- HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types
- (2018) Anne Zirkel et al. MOLECULAR CELL
- Single-cell bioluminescence imaging of deep tissue in freely moving animals
- (2018) Satoshi Iwano et al. SCIENCE
- Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome
- (2018) Zeming Wu et al. Protein & Cell
- HBO1 promotes cell proliferation in bladder cancer via activation of Wnt/β-catenin signaling
- (2017) Zhaohui Chen et al. MOLECULAR CARCINOGENESIS
- Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan
- (2017) Shuo Han et al. NATURE
- Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
- (2017) Nard Kubben et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human Ageing Genomic Resources: new and updated databases
- (2017) Robi Tacutu et al. NUCLEIC ACIDS RESEARCH
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- Repression of the Antioxidant NRF2 Pathway in Premature Aging
- (2016) Nard Kubben et al. CELL
- SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
- (2016) Huize Pan et al. CELL RESEARCH
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
- (2016) Bastiaan Evers et al. NATURE BIOTECHNOLOGY
- Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
- (2016) David W Morgens et al. NATURE BIOTECHNOLOGY
- Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
- (2016) Gozde Korkmaz et al. NATURE BIOTECHNOLOGY
- The Metabolic Impact on Histone Acetylation and Transcription in Ageing
- (2016) Shahaf Peleg et al. TRENDS IN BIOCHEMICAL SCIENCES
- Reorganization of chromosome architecture in replicative cellular senescence
- (2016) Steven W. Criscione et al. Science Advances
- Epigenetics and aging
- (2016) S. Pal et al. Science Advances
- DNA methylation and healthy human aging
- (2015) Meaghan J. Jones et al. AGING CELL
- A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
- (2015) W. Zhang et al. SCIENCE
- Nuclear lamina remodelling and its implications for human disease
- (2014) Alexandre Chojnowski et al. CELL AND TISSUE RESEARCH
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- CRISPR-Cas systems for editing, regulating and targeting genomes
- (2014) Jeffry D Sander et al. NATURE BIOTECHNOLOGY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome
- (2014) David A. Orlando et al. Cell Reports
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
- (2012) Bruno Bernardes de Jesus et al. EMBO Molecular Medicine
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development
- (2010) A. J. Kueh et al. MOLECULAR AND CELLULAR BIOLOGY
- Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
- (2010) Mariela Jaskelioff et al. NATURE
- Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
- (2010) G. Marino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential expression analysis for sequence count data
- (2010) Simon Anders et al. GENOME BIOLOGY
- ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders
- (2009) Jemima Barrowman et al. BIOLOGICAL CHEMISTRY
- Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation
- (2009) Alessio Zippo et al. CELL
- Histone H4 lysine 16 acetylation regulates cellular lifespan
- (2009) Weiwei Dang et al. NATURE
- Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
- (2008) Antonia Tomás-Loba et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Cellular senescence and organismal aging
- (2008) Jessie C. Jeyapalan et al. MECHANISMS OF AGEING AND DEVELOPMENT
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started