Cell non-autonomous regulation of health and longevity

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans

(2020) Ashley E. Frakes et al.   SCIENCE

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

(2020) Andrew Rallis et al.   Cell Reports

UPRER promotes lipophagy independent of chaperones to extend life span

(2020) Joseph R. Daniele et al.   Science Advances

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

(2020) Matthew J. Yousefzadeh et al.   GeroScience

Sensory perception of dead conspecifics induces aversive cues and modulates lifespan through serotonin in Drosophila

(2019) Tuhin S. Chakraborty et al.   Nature Communications

Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans

(2019) Soudabeh Imanikia et al.   CURRENT BIOLOGY

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

XBP-1 Remodels Lipid Metabolism to Extend Longevity

(2019) Soudabeh Imanikia et al.   Cell Reports

The flight response impairs cytoprotective mechanisms by activating the insulin pathway

(2019) María José De Rosa et al.   NATURE

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

(2019) Jorge Iván Castillo-Quan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

(2019) Yue Zhang et al.   eLife

Regulation of lifespan by neural excitation and REST

(2019) Joseph M. Zullo et al.   NATURE

Proteostasis collapse is a driver of cell aging and death

(2019) Mantu Santra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism

(2019) Aude D. Bouagnon et al.   PLOS BIOLOGY

Brain–gut communications via distinct neuroendocrine signals bidirectionally regulate longevity inC. elegans

(2018) Bi Zhang et al.   GENES & DEVELOPMENT

Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

(2018) Kathrin Steck et al.   eLife

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

A functional study of all 40 C. elegans insulin-like peptides

(2018) Shanqing Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis

(2018) Alicia N. Minniti et al.   AGING CELL

Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2

(2018) Stephanie Post et al.   AGING CELL

Food responsiveness regulates episodic behavioral states in Caenorhabditis elegans

(2017) Richard J. McCloskey et al.   JOURNAL OF NEUROPHYSIOLOGY

The hypothalamus at the crossroads of psychopathology and neurosurgery

(2017) Daniel A. N. Barbosa et al.   Neurosurgical Focus

Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger

(2017) Qili Liu et al.   SCIENCE

Perceptive costs of reproduction drive ageing and physiology in male Drosophila

(2017) Zachary M. Harvanek et al.   Nature Ecology & Evolution

An automated compound screening for anti-aging effects on the function of C. elegans sensory neurons

(2017) Daphne Bazopoulou et al.   Scientific Reports

Basal body temperature as a biomarker of healthy aging

(2016) Eleanor M. Simonsick et al.   AGE

Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides

(2016) Murat Artan et al.   GENES & DEVELOPMENT

AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators

(2016) Elizabeth Moreno-Arriola et al.   PLoS One

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Serotonin signaling mediates protein valuation and aging

(2016) Jennifer Ro et al.   eLife

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

(2015) Jennifer Nicola M. Rea et al.   BIOGERONTOLOGY

What is hormesis and its relevance to healthy aging and longevity?

(2015) Edward J. Calabrese et al.   BIOGERONTOLOGY

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

(2015) Kristopher Burkewitz et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase

(2015) Marcus C. Tatum et al.   CURRENT BIOLOGY

Endocrine aspects of organelle stress — cell non-autonomous signaling of mitochondria and the ER

(2015) Robert Schinzel et al.   CURRENT OPINION IN CELL BIOLOGY

Adaptive Physiological Response to Perceived Scarcity as a Mechanism of Sensory Modulation of Life Span

(2015) Michael J. Waterson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

(2015) Rachel Kaletsky et al.   NATURE

Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

(2015) Natalia V. Bobkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gustatory and metabolic perception of nutrient stress inDrosophila

(2015) Nancy J. Linford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

(2015) S. F. Leiser et al.   SCIENCE

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity

(2015) Peter M. Douglas et al.   Cell Reports

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling

(2014) Céline E. Riera et al.   CELL

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling

(2014) I. Ostojic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling

(2014) M. J. Waterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

(2014) M. Eren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans

(2014) Ramesh Ratnappan et al.   PLoS Genetics

Integrin-linked kinase modulates longevity and thermotolerance inC. elegansthrough neuronal control of HSF-1

(2013) Caroline Kumsta et al.   AGING CELL

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

DRD4 Genotype Predicts Longevity in Mouse and Human

(2013) D. L. Grady et al.   JOURNAL OF NEUROSCIENCE

Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1

(2013) Scott F. Leiser et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward

(2013) C. M. Gendron et al.   SCIENCE

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

(2013) M. Catarina Silva et al.   PLoS Genetics

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction

(2013) Kavitha Kannan et al.   Frontiers in Physiology

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

(2012) Michael J. Steinbaugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO

(2012) Konstantinos Boulias et al.   Cell Metabolism

Unique roles of glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects

(2012) Andrea Bednářová et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

New genes that extend Caenorhabditis elegans’ lifespan in response to reproductive signals

(2011) Mark McCormick et al.   AGING CELL

Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan

(2011) Rochele Yamamoto et al.   AGING CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Monoamines and neuropeptides interact to inhibit aversive behaviour inCaenorhabditis elegans

(2011) Holly Mills et al.   EMBO JOURNAL

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

(2010) Susan J. Broughton et al.   AGING CELL

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Partial ablation of adult Drosophilainsulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance

(2010) Aaron Haselton et al.   CELL CYCLE

Insulin Signaling, Lifespan and Stress Resistance Are Modulated by Metabotropic GABA Receptors on Insulin Producing Cells in the Brain of Drosophila

(2010) Lina E. Enell et al.   PLoS One

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

(2010) Tracy M. Yamawaki et al.   PLOS BIOLOGY

Carbon Dioxide Sensing Modulates Lifespan and Physiology in Drosophila

(2010) Peter C. Poon et al.   PLOS BIOLOGY

Manipulation of Behavioral Decline in Caenorhabditis elegans with the Rag GTPase raga-1

(2010) Matthew A. Schreiber et al.   PLoS Genetics

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

A High-Throughput Screen for Chemicals that Increase the Lifespan of Caenorhabditis elegans

(2009) Michael Petrascheck et al.   Annals of the New York Academy of Sciences

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Regulation of the Longevity Response to Temperature by Thermosensory Neurons in Caenorhabditis elegans

(2009) Seung-Jae Lee et al.   CURRENT BIOLOGY

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

(2009) Dickon M. Humphrey et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms

(2008) Supriya Srinivasan et al.   Cell Metabolism

Insulin, cGMP, and TGF-β Signals Regulate Food Intake and Quiescence in C. elegans: A Model for Satiety

(2008) Young-jai You et al.   Cell Metabolism

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY