Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis
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Title
Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis
Authors
Keywords
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Journal
Genes
Volume 13, Issue 1, Pages 138
Publisher
MDPI AG
Online
2022-01-14
DOI
10.3390/genes13010138
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- Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis
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- Meta-analysis of genome-wide studies identifiesWNT16andESR1SNPs associated with bone mineral density in premenopausal women
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- Van Buchem disease: Clinical, biochemical, and densitometric features of patients and disease carriers
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- Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cells
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- Mutations inWNT10Aare present in more than half of isolated hypodontia cases
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- Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers
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- Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells
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- Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
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- Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis
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- High-Affinity Dkk1 Receptor Kremen1 Is Internalized by Clathrin-Mediated Endocytosis
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- Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
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- Targeted deletion of Sost distal enhancer increases bone formation and bone mass
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- Structural Basis of Wnt Recognition by Frizzled
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- Secreted and Transmembrane Wnt Inhibitors and Activators
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- Alternative Wnt Pathways and Receptors
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- Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus
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- WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
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- The Role of BMPs in Bone Anabolism and their Potential Targets SOST and DKK1
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- The role of WNT10B in physiology and disease
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- Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells
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- Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells
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- Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
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- Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism
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- Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling
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- Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling
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- Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
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- Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
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- Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor
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- Sostdown-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
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- Expression patterns of lgr4 and lgr6 during zebrafish development
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- Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia
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- Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function
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- Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury
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- Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover
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- Determinants of serum sclerostin in healthy pre- and postmenopausal women
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- DNA methylation contributes to the regulation of sclerostin expression in human osteocytes
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- Mef2cdeletion in osteocytes results in increased bone mass
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- WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
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- Sclerostin and Its Association with Physical Activity, Age, Gender, Body Composition, and Bone Mineral Content in Healthy Adults
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- Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
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- Lrp5 functions in bone to regulate bone mass
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- The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells
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- Mesodermal Progenitor Cells (MPCs) Differentiate into Mesenchymal Stromal Cells (MSCs) by Activation of Wnt5/Calmodulin Signalling Pathway
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- The Emerging Role of Dickkopf-1 in Bone Biology: Is It the Main Switch Controlling Bone and Joint Remodeling?
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- Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
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- LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome
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- Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis
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- Dynamics of the transition from osteoblast to osteocyte
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- R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway
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- Sclerostin is a direct target of osteoblast-specific transcription factor osterix
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- Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling
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- Genetic Analysis of Lrp5 Function in Osteoblast Progenitors
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- Two families confirm Schöpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum
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- Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
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- Wnt modulators in the biotech pipeline
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- Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3β-dependent and β-catenin-independent mechanism
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- Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells
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- First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function
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- Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways
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- sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial Repair
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- Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6
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- Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice
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- Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells
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- Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength
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- PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
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- Relation of age, gender, and bone mass to circulating sclerostin levels in women and men
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- Serum Sclerostin Levels Negatively Correlate with Parathyroid Hormone Levels and Free Estrogen Index in Postmenopausal Women
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- Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
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- Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome
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- Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
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- Opposite Spectrum of Activity of Canonical Wnt Signaling in the Osteogenic Context of Undifferentiated and Differentiated Mesenchymal Cells: Implications for Tissue Engineering
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- WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes
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- Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin
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- Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells
- (2009) Sun Wook Cho et al. BONE
- Identification of differentially expressed genes between osteoblasts and osteocytes
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- Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis
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- Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
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- Regulation of bone formation and remodeling by G-protein-coupled receptor 48
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- Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range
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- Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
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- Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
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- Characterization of the Structural Features and Interactions of Sclerostin
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- Role of Wnt-5a in the Determination of Human Mesenchymal Stem Cells into Preadipocytes
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- The Matricellular Protein Periostin Is Required forSostInhibition and the Anabolic Response to Mechanical Loading and Physical Activity
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- Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals
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- Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects
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- Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
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- Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells
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- Effects of age and gender on WNT gene expression in human bone marrow stromal cells
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- Secreted frizzled related protein 1 is a target to improve fracture healing
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- Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
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- Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
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- Proximal events in Wnt signal transduction
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- Motor Neurons with Axial Muscle Projections Specified by Wnt4/5 Signaling
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- Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo
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- Wnt Signaling from Development to Disease: Insights from Model Systems
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- Wnt signaling: A win for bone
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- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
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- Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts
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- The role of Dickkopf-1 in bone development, homeostasis, and disease
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- The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations
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- Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
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- Ratio of Wnt3a to BMP4 doses is critical to their synergistic effects on proliferation of differentiating mouse embryonic stem cells
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- Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
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- Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling
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- Parathyroid hormone signaling through low-density lipoprotein-related protein 6
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- Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β-catenin and the planar cell polarity pathways during early trunk formation in mouse
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- Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation
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- Msx2 Exerts Bone Anabolism via Canonical Wnt Signaling
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- Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk
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- Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd
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- Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
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- Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
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- Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*
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- Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
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- Brachy-syndactyly caused by loss ofSfrp2function
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- Expanding functions of lipoprotein receptors
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- Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
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- Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
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- Lgr5 marks cycling, yet long-lived, hair follicle stem cells
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- The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate
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- Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival
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- Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development
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- Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2
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- Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
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- Context-Dependent Activation or Inhibition of Wnt- -Catenin Signaling by Kremen
- (2008) C. S. Cselenyi et al. Science Signaling
- Alternative Wnt Signaling Is Initiated by Distinct Receptors
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- Wnt signaling and skeletal development
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- A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer
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