Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice

Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression

(2016) Natalie H. Kelly et al.   BONE

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

(2015) N. Lara-Castillo et al.   BONE

Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption

(2015) Hajar Razi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6

(2014) Nilsson Holguin et al.   BONE

The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations

(2014) Kyu Sang Joeng et al.   HUMAN MOLECULAR GENETICS

The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice

(2014) Nilsson Holguin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Age-Related Impairment of Bones' Adaptive Response to Loading in Mice Is Associated With Sex-Related Deficiencies in Osteoblasts but No Change in Osteocytes

(2014) Lee B Meakin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation

(2014) Si Hui Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch from Canonical to Noncanonical Wnt Signaling Mediates High Glucose-Induced Adipogenesis

(2014) Emily C. Keats et al.   STEM CELLS

WNT7B Promotes Bone Formation in part through mTORC1

(2014) Jianquan Chen et al.   PLoS Genetics

Inactivation of Lrp5 in osteocytes reduces Young's modulus and responsiveness to the mechanical loading

(2013) Liming Zhao et al.   BONE

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight

(2013) Lee B. Meakin et al.   BONE

Adaptation of Tibial Structure and Strength to Axial Compression Depends on Loading History in Both C57BL/6 and BALB/c Mice

(2013) Nilsson Holguin et al.   CALCIFIED TISSUE INTERNATIONAL

Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice

(2013) Tarpit K. Patel et al.   JOURNAL OF BIOMECHANICS

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

(2013) Behzad Javaheri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

(2013) Christine M. Laine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton

(2012) Sundar Srinivasan et al.   AGEING RESEARCH REVIEWS

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition

(2012) Toshihiro Sugiyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tibial Loading Increases Osteogenic Gene Expression and Cortical Bone Volume in Mature and Middle-Aged Mice

(2012) Matthew J. Silva et al.   PLoS One

Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging

(2011) Maureen E. Lynch et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

(2011) A. Moustafa et al.   OSTEOPOROSIS INTERNATIONAL

Short-term low-strain vibration enhances chemo-transport yet does not stimulate osteogenic gene expression or cortical bone formation in adult mice

(2010) Akhilesh A. Kotiya et al.   BONE

Aging changes mechanical loading thresholds for bone formation in rats

(2010) Charles H. Turner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis

(2010) A.M. Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression

(2010) Michael D Brodt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gene expression patterns in bone following mechanical loading

(2010) Sara M Mantila Roosa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Rescuing Loading Induced Bone Formation at Senescence

(2010) Sundar Srinivasan et al.   PLoS Computational Biology

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor α and disuse

(2009) Gul Zaman et al.   BONE

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE