Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction

(2013) Jiong Li et al.   Cell Reports

Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche

(2012) Ryohichi Sugimura et al.   CELL

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism

(2012) Qian Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts

(2012) J. B. Regard et al.   Cold Spring Harbor Perspectives in Biology

Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells

(2011) Weimin Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway

(2011) Krista M. Heinonen et al.   PLoS One

MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells

(2011) Amitabh C Pandey et al.   Stem Cell Research & Therapy

Functions of nuclear factor κB in bone

(2010) Brendan F. Boyce et al.   Annals of the New York Academy of Sciences

TAB2 Scaffolds TAK1 and NLK in Repressing Canonical Wnt Signaling

(2010) Meng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

(2010) Patrick Garnero et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shcSignaling Cascade: Counter Regulation by Estrogens or Androgens

(2010) Maria Almeida et al.   MOLECULAR ENDOCRINOLOGY

When pathways collide: collaboration and connivance among signalling proteins in development

(2010) Helen McNeill et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel functions for NFκB: inhibition of bone formation

(2010) Susan A. Krum et al.   Nature Reviews Rheumatology

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

BCOR regulates mesenchymal stem cell function by epigenetic mechanisms

(2009) Zhipeng Fan et al.   NATURE CELL BIOLOGY

Inhibition of osteoblastic bone formation by nuclear factor-κB

(2009) Jia Chang et al.   NATURE MEDICINE

Proinflammatory cytokines and osteoporosis

(2009) Robert R. McLean   Current Osteoporosis Reports

Wnt-ligand-dependent interaction of TAK1 (TGF-β-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

(2008) Andreas Winkel et al.   CELLULAR SIGNALLING

Ubiquitin Ligase Smurf1 Mediates Tumor Necrosis Factor-induced Systemic Bone Loss by Promoting Proteasomal Degradation of Bone Morphogenetic Signaling Proteins

(2008) Ruolin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts

(2008) Shuting Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Building bone to reverse osteoporosis and repair fractures

(2008) Sundeep Khosla et al.   JOURNAL OF CLINICAL INVESTIGATION