WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

(2016) Dongwon Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Axin2marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling

(2016) Xinhong Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

(2016) H. Matsumura et al.   SCIENCE

Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients

(2016) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients

(2016) Binghui Zeng et al.   Genes

WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

(2015) Apple Long et al.   CARCINOGENESIS

Normal Taste Acceptance and Preference of PANX1 Knockout Mice

(2015) Michael G. Tordoff et al.   CHEMICAL SENSES

Progress and renewal in gustation: new insights into taste bud development

(2015) L. A. Barlow   DEVELOPMENT

Wntless Regulates Dentin Apposition and Root Elongation in the Mandibular Molar

(2015) C.H. Bae et al.   JOURNAL OF DENTAL RESEARCH

Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

(2015) Rene C. Adam et al.   NATURE

Lgr6 marks nail stem cells and is required for digit tip regeneration

(2015) Jessica A. Lehoczky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates

(2015) Dany Gaillard et al.   PLoS Genetics

Dynamics of Lgr6 + Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis

(2015) Anja Füllgrabe et al.   Stem Cell Reports

The WNT10A gene in ectodermal dysplasias and selective tooth agenesis

(2014) Gabriele Mues et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Clinical features andWNT10Amutations in seven unrelated cases of Schöpf-Schulz-Passarge syndrome

(2014) C. Tziotzios et al.   BRITISH JOURNAL OF DERMATOLOGY

Involvement of Wnt, Eda and Shh at defined stages of sweat gland development

(2014) C.-Y. Cui et al.   DEVELOPMENT

Plasticity of epithelial stem cells in tissue regeneration

(2014) C. Blanpain et al.   SCIENCE

Taurodontism, variations in tooth number, and misshapened crowns inWnt10anull mice and human kindreds

(2014) Jie Yang et al.   Molecular Genetics & Genomic Medicine

Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis

(2013) Yeon Sook Choi et al.   Cell Stem Cell

Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

(2013) Stefanie Heilmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratin 9 Is Required for the Structural Integrity and Terminal Differentiation of the Palmoplantar Epidermis

(2013) Dun Jack Fu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wnt activation in nail epithelium couples nail growth to digit regeneration

(2013) Makoto Takeo et al.   NATURE

Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling

(2013) X. Lim et al.   SCIENCE

Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue

(2013) Karen K. Yee et al.   STEM CELLS

Late diagnosis of ectodermal dysplasia syndrome

(2012) Robert H Granger et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair

(2012) Catherine P. Lu et al.   CELL

ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal Differentiation

(2012) George L. Sen et al.   DEVELOPMENTAL CELL

Neural Crest Deletion of Dlx3 Leads to Major Dentin Defects through Down-regulation of Dspp

(2012) Olivier Duverger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations inWNT10Aare present in more than half of isolated hypodontia cases

(2012) Marie-José van den Boogaard et al.   JOURNAL OF MEDICAL GENETICS

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

(2012) Panteleimon Rompolas et al.   NATURE

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

(2012) L. A. Garza et al.   Science Translational Medicine

Wnt Proteins

(2012) K. Willert et al.   Cold Spring Harbor Perspectives in Biology

A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse

(2011) Anna Ferrer-Vaquer et al.   BMC DEVELOPMENTAL BIOLOGY

Taste bud cells of adult mice are responsive to Wnt/β-catenin signaling: Implications for the renewal of mature taste cells

(2011) Dany Gaillard et al.   GENESIS

Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4

(2010) Sayumi Fujimori et al.   DEVELOPMENTAL BIOLOGY

The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12

(2010) Danielle R. Reed et al.   HUMAN MOLECULAR GENETICS

Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases

(2010) Céline Cluzeau et al.   HUMAN MUTATION

β-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors

(2010) F. Liu et al.   JOURNAL OF DENTAL RESEARCH

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

(2009) Axel Bohring et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

(2009) Kim B. Jensen et al.   Cell Stem Cell

Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction

(2009) Yuhang Zhang et al.   DEVELOPMENTAL CELL

Dlx3 is a crucial regulator of hair follicle differentiation and cycling

(2008) J. Hwang et al.   DEVELOPMENT

Activation of  -catenin signaling programs embryonic epidermis to hair follicle fate

(2008) Y. Zhang et al.   DEVELOPMENT

A dermal HOX transcriptional program regulates site-specific epidermal fate

(2008) J. L. Rinn et al.   GENES & DEVELOPMENT

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

(2008) Ilaria Malanchi et al.   NATURE

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

(2008) Steven Hoseong Yang et al.   NATURE GENETICS

Wnt/β-catenin signaling directs multiple stages of tooth morphogenesis

(2007) Fei Liu et al.   DEVELOPMENTAL BIOLOGY