Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ming Cai, Wei-Jian Ni, Ying-Hong Wang, Jing-Ji Wang, Hong Zhou
Summary: The morbidity and mortality of malignant tumors are increasing, and current treatment strategies are limited. TMEM88, a double-transmembrane protein, has been found to be involved in cell proliferation, differentiation, apoptosis, and tumor progression. Abnormal changes in TMEM88 have been discovered in various malignant tumors, attracting attention for its potential therapeutic value. This article aims to describe the changes in TMEM88 in malignant tumors and summarize the corresponding molecular mechanisms, exploring the potential of targeting TMEM88 for the treatment of malignant tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Article
Oncology
Ayumi Kanemaru, Yuki Ito, Michiko Yamaoka, Yuki Shirakawa, Kou Yonemaru, Shunsuke Miyake, Misaki Ando, Masako Ota, Takeshi Masuda, Akitake Mukasa, Jian-Dong Li, Hideyuki Saito, Takuichiro Hide, Hirofumi Jono
Summary: The downregulation of tumor suppressor CYLD is associated with poor prognosis in GBM patients. The Wnt/β-catenin signaling pathway is significantly activated in CYLD-downregulated GBM patients. Inhibiting this pathway can suppress the malignant characteristics induced by CYLD downregulation in GBM.
Article
Cell Biology
Xiu-Ling Liang, Yu-Long Wang, Pei-Rong Wang
Summary: MiR-200a plays a crucial role in the malignant progression of tumors, with potential implications for Wilm's tumor. Lower expression of miR-200a in Wilm's tumor tissues and cells is associated with poorer outcomes and increased cell death. Additionally, miR-200a targets and inhibits CDC7 in Wilm's tumor cells, impacting cell viability and apoptosis. Further research into the miR-200a/CDC7 axis and its effects on the Wnt/beta-catenin signaling pathway provide a foundation for potential targeted molecular therapies for Wilm's tumor.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Cell Biology
Dimitri Papukashvili, Nino Rcheulishvili, Cong Liu, Fengfei Xie, Deependra Tyagi, Yunjiao He, Peng George Wang
Summary: Androgenetic alopecia (AGA) is a challenging issue that requires the development of new treatment methods. The Wnt/β-catenin signaling pathway is crucial for hair growth and can be targeted for AGA therapy.
Article
Oncology
Wenyu Wang, Untack Cho, Anna Yoo, Chae-Lim Jung, Boyun Kim, Heeyeon Kim, Juwon Lee, HyunA Jo, Youngjin Han, Myoung-Hyun Song, Ja-Oh Lee, Se Ik Kim, Maria Lee, Ja-Lok Ku, Cheol Lee, Yong Sang Song
Summary: This study provides the first evidence for the anti-tumor effect of CWP232291 in ovarian cancer and suggests the inhibition of the Wnt/beta-catenin pathway as a novel therapeutic strategy against ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Food Science & Technology
Faezeh Malakoti, Erfan Mohammadi, Mahsa Akbari Oryani, Darioush Shanebandi, Bahman Yousefi, Azadeh Salehi, Zatollah Asemi
Summary: MiRNAs play a role in the occurrence and development of diabetic complications by interacting with mRNA to prevent translation, and polyphenols are considered safe drugs for treating diabetic complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Plant Sciences
Xinxin Xie, Jinxiao Chen, Da Wo, En Ma, Yongling Ning, Jun Peng, Weidong Zhu, Dan-ni Ren
Summary: The study revealed that Babao Dan inhibits tumor proliferation and stem-like properties of cancer stem cells by targeting the Wnt/beta-catenin signaling pathway, indicating its potential clinical application in cancer treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rui Bai, Cheng Yuan, Wenjie Sun, Jianguo Zhang, Yuan Luo, Yanping Gao, Yangyi Li, Yan Gong, Conghua Xie
Summary: NEK2 plays a crucial role in the oncogenesis of non-small cell lung cancer, with its deficiency inhibiting tumor cell proliferation, migration, and invasion, as well as affecting macrophage polarization and angiogenesis in the tumor microenvironment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pharmacology & Pharmacy
Shan-Shan Li, Qian Sun, Meng-Ru Hua, Ping Suo, Jia-Rong Chen, Xiao-Yong Yu, Ying-Yong Zhao
Summary: The Wnt/β-catenin signaling pathway is crucial in renal fibrosis, controlling downstream mediators in various cell types and interacting with other pathways to promote fibrosis. Blocking this pathway may be beneficial for fibrosis treatment. Antagonists of Wnt signaling and small-molecule β-catenin inhibitors show potential therapeutic effects in preventing and treating renal fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongzao Ni, Daofei Ji, Jing Li, Zongren Zhao, Jiandong Zuo
Summary: The study revealed that IPO11 knockdown suppressed the malignant phenotypes of glioma cells by inactivating the Wnt/beta-catenin pathway, leading to inhibition of cell proliferation, promotion of apoptosis, and suppression of invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Man Zhang, Jinhua Zheng, Junying Guo, Qiujin Zhang, Juan Du, Xiangfeng Zhao, Zhihua Wang, Qinyuan Liao
Summary: Breast cancer has the highest incidence rate in the world, and therapy resistance of breast cancer stem cells (CSCs) poses a major challenge in clinical treatment. This study identifies SIA-IgG as a potential therapeutic target in breast cancer and investigates its functional changes and molecular mechanisms. The results provide a potential prognostic marker and a novel therapeutic target for breast cancer.
