BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling

Teriparatide [rhPTH(1-34)] Increases foot Bone Remodeling In Diabetic Chronic Charcot’s Neuroarthropathy: A Randomized, Double Blind, Placebo-Controlled Study

(2019) Ashu Rastogi et al.   Journal of Diabetes

BMP9 stimulates joint regeneration at digit amputation wounds in mice

(2019) Ling Yu et al.   Nature Communications

Dentinogenesis and tooth-alveolar bone complex defects in BMP9/GDF2 knockout mice

(2019) Xia Huang et al.   STEM CELLS AND DEVELOPMENT

Multicellularity-interweaved bone regeneration of BMP-2-loaded scaffold with orchestrated kinetics of resorption and osteogenesis

(2019) Haoyi Niu et al.   BIOMATERIALS

BMP 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting from hepatic fibrosis

(2019) Agnès Desroches‐Castan et al.   HEPATOLOGY

Role of bone morphogenetic protein-9 in the regulation of glucose and lipid metabolism

(2019) Min Yang et al.   FASEB JOURNAL

The effects of tranylcypromine on osteoclastogenesis in vitro and in vivo

(2019) Zhuochao Liu et al.   FASEB JOURNAL

Absence of Dipeptidyl Peptidase 3 increases oxidative stress and causes bone loss

(2019) Ciro Menale et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone-Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment

(2019) Pascale Chavassieux et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis

(2019) Yuyu Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma

(2018) Elena Porcù et al.   CELL DEATH AND DIFFERENTIATION

Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure

(2018) Kevin J. Morine et al.   CIRCULATION

A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss

(2018) Min Jiang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells

(2018) Jing Cui et al.   LABORATORY INVESTIGATION

BMP-9 interferes with liver regeneration and promotes liver fibrosis

(2017) Katja Breitkopf-Heinlein et al.   GUT

Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae

(2017) Meng Zhou et al.   JOURNAL OF MOLECULAR HISTOLOGY

Osteoporosis: Staying strong

(2017) Carolyn Brown   NATURE

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

(2017) Kenneth G. Saag et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

BMP9 a possible alternative drug for the recently withdrawn BMP7? New perspectives for (re-)implementation by personalized medicine

(2016) Vrinda Sreekumar et al.   ARCHIVES OF TOXICOLOGY

Postmenopausal Osteoporosis

(2016) Dennis M. Black et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins

(2016) Harmen van Andel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Morphogenetic Proteins

(2016) Takenobu Katagiri et al.   Cold Spring Harbor Perspectives in Biology

Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs)

(2015) Hongmei Zhang et al.   BIOMATERIALS

WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice

(2015) Yoon-Hee Cheon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lgr6 marks nail stem cells and is required for digit tip regeneration

(2015) Jessica A. Lehoczky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emodin Regulates Bone Remodeling by Inhibiting Osteoclastogenesis and Stimulating Osteoblast Formation

(2014) Ju-Young Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

R-spondins: Novel matricellular regulators of the skeleton

(2014) M. Noelle Knight et al.   MATRIX BIOLOGY

Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes

(2013) R. A. DeFronzo et al.   DIABETES CARE

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Osteoporosis in the European Union: medical management, epidemiology and economic burden

(2013) E. Hernlund et al.   Archives of Osteoporosis

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of Osteoclast Generation: A Novel Function of the Bone Morphogenetic Protein 7/Osteogenic Protein 1

(2012) Thomas Maurer et al.   MEDIATORS OF INFLAMMATION

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

LGR6 Is a High Affinity Receptor of R-Spondins and Potentially Functions as a Tumor Suppressor

(2012) Xing Gong et al.   PLoS One

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP2/7 Heterodimer Can Modulate All Cellular Events of the In Vitro RANKL-Mediated Osteoclastogenesis, Respectively, in Different Dose Patterns

(2011) Yuanna Zheng et al.   TISSUE ENGINEERING PART A

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity

(2010) Masanori Kanatani et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Is Wnt signalling the final common pathway leading to bone formation?

(2009) Frances Milat et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/β-catenin signalling

(2008) Ni Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation

(2007) Meiheng Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY