Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Fanglin Wang, Qiao Wang, Yu Zhao, Zhiyu Tian, Shijie Chang, Hao Tong, Ningwei Liu, Shuling Bai, Xiang Li, Jun Fan
Summary: This study investigated the role of miR-150-5p and its related mechanisms in the osteogenesis of adipose-derived mesenchymal stem cells (ADSCs). The results showed that miR-150-5p regulates Notch3 during ADSCs osteogenesis. It was found that inhibition of miR-150-5p enhanced the osteogenic capacity of ADSCs, and partially reversed the inhibition effect of Notch3 knockdown on osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Chiara Della Bella, Antonio Antico, Maria Piera Panozzo, Nagaja Capitani, Luisa Petrone, Marisa Benagiano, Sofia D'Elios, Clotilde Sparano, Annalisa Azzurri, Sara Pratesi, Fabio Cianchi, Diana Ortiz-Princz, Mathijs Bergman, Nicola Bizzaro, Mario Milco D'Elios
Summary: This study investigated the gastric H+/K+-ATPase-specific Th17 responses and serum IL-17 cytokine subfamily in AIG patients, showing that gastric LPMCs from AIG patients are activated by H+/K+-ATPase and produce high levels of IL-17A and IL-17F, while serum IL-17A, IL-17F, IL-21, and IL-17E levels are significantly elevated in AIG patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael Crawford, Nicholas Borcherding, Nitin Karandikar
Summary: CD4(+) T-helper 17 (Th17) T cells play a crucial role in promoting inflammation through the secretion of IL-17 and are a major therapeutic target for autoimmune disorders. Recent studies have shown that IL-17 family cytokines can directly act on CD4(+) T cells, specifically naive cells, leading to functional changes. The differences in downstream signaling and functional consequences suggest that IL-17AF heterodimer is the most influential cytokine.
Article
Immunology
Sun-Hee Hwang, Jin Seok Woo, Jeonghyeon Moon, SeungCheon Yang, Jin-Sil Park, JaeSeon Lee, JeongWon Choi, Kun Hee Lee, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho
Summary: The study found that the increase of IL-17 is associated with aging and metabolic abnormalities, and may play a key role in the onset and progression of SS.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Jia-Lu Shi, Zi-Meng Zheng, Min Chen, Hui-Hui Shen, Ming-Qing Li, Jun Shao
Summary: Interleukin-17 (IL-17) is a proinflammatory cytokine derived from Th17 cells, which plays a pivotal role in inflammatory and autoimmune diseases. It is also linked to endometriosis, where IL-17 expression is up-regulated. IL-17 is involved in the regulation of immune microenvironment and the growth and invasion of ectopic lesions, suggesting its therapeutic value in endometriosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Chenyi Shao, Yi Liu, Jiaci Li, Ziyun Liu, Yuxia Zhao, Yaqing Jing, Zhe Lv, Ting Fu, Zihan Wang, Guang Li
Summary: Osteogenesis imperfecta (OI), a congenital bone dysplasia, is mainly caused by defective production or assembly of type I collagen. Studies have found that increased osteoclasts and excessive bone resorption exist in collagen-related OI, which is associated with inflammation. Transcriptomic analysis of bone marrow cells from OI mouse models revealed dysregulated genes and pathways related to interferon response, IL17 signaling, tumor necrosis factor signaling, and osteoclast differentiation. These findings contribute to understanding the mechanism of enhanced bone absorption in OI and provide evidence for potential anti-inflammatory therapies.
Editorial Material
Immunology
Joanna R. Groom, James E. Vince
Summary: A T(H)17 cell NLRP3-caspase-8-caspase-3-GSDME axis is found to release the alarmin IL-1 alpha without inducing cell death.
Article
Cell & Tissue Engineering
Jingyan Guan, Yibao Li, Feng Lu, Jingwei Feng
Summary: Adipose-derived stem cells (ADSCs) ameliorate ovalbumin-induced atopic dermatitis (AD) in mice mainly by downregulating IL-17 secretion of Th17 cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Isabel Vogel, Valerie Acolty, Tibor Keler, Stanislas Goriely, Oberdan Leo, Muriel Moser
Summary: CD27/CD70 costimulation enhances T-cell function and suppresses IL-17 production, suggesting its potential as a therapeutic target for diseases characterized by excessive IL-17 production.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Review
Neurosciences
Jingjing Wang, Yuxiao Gao, Yujia Yuan, Huan Wang, Zhao Wang, Xiangjian Zhang
Summary: This paper reviews the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shun-Cheng Wu, Chih-Hsiang Chang, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Yi-Shan Lin, Je-Ken Chang, Mei-Ling Ho
Summary: The study found that simvastatin (SIM) can enhance ADSC-based chondrogenesis in the presence of hyaluronan (HA) microenvironment (HAM) while avoiding osteogenesis.
Article
Cell Biology
Nan Li, Shulin Chen, Weiqing Deng, Zhaohui Gong, Yu Guo, Shan Zeng, Qiang Xu
Summary: This study explored the potential mechanisms by which kaempferol regulates gouty arthritis (GA) through network pharmacology and experimental validation. The results showed that kaempferol exerts therapeutic effects on GA by regulating the IL-17, AGE-RAGE, p53, TNF, and FoxO signaling pathways. Experimental validation supported the clinical use of kaempferol for GA treatment.
Review
Immunology
Ritesh Kumar, Arianne L. Theiss, K. Venuprasad
Summary: ROR gamma t plays a crucial role in regulating IL-17-driven inflammation through multiple post-translational modifications. Understanding these pathways is essential for studying the pathogenic role of ROR gamma t+IL-17+ cells and developing potential therapeutic strategies.
TRENDS IN IMMUNOLOGY
(2021)