Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 48, Pages E5187-E5195
Publisher
Proceedings of the National Academy of Sciences
Online
2014-11-20
DOI
10.1073/pnas.1413828111
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta
- (2014) Christina M Jacobsen et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo
- (2014) M. K. Chang et al. JOURNAL OF IMMUNOLOGY
- Romosozumab in Postmenopausal Women with Low Bone Mineral Density
- (2014) Michael R. McClung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Severe Cenani-Lenz syndrome caused by loss of LRP4 function
- (2013) Ariana Kariminejad et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation
- (2013) Stevan R. Hubbard et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- A common LRP4 haplotype is associated with bone mineral density and hip geometry in men—Data from the Odense Androgen Study (OAS)
- (2013) Eveline Boudin et al. BONE
- LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner
- (2013) Bisei Ohkawara et al. HUMAN MOLECULAR GENETICS
- Systemic Administration of Sclerostin Antibody Enhances Bone Repair in a Critical-Sized Femoral Defect in a Rat Model
- (2013) Mandeep S. Virk et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- ReversingLRP5-Dependent Osteoporosis andSOSTDeficiency-Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
- (2013) Ming-Kang Chang et al. JOURNAL OF BONE AND MINERAL RESEARCH
- WNT signaling in bone homeostasis and disease: from human mutations to treatments
- (2013) Roland Baron et al. NATURE MEDICINE
- Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome
- (2013) R. Kedlaya et al. Science Translational Medicine
- Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors
- (2012) Gill Holdsworth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta
- (2012) Benjamin P Sinder et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
- (2012) David W Dempster et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses
- (2012) Norihiro Yumoto et al. NATURE
- WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
- (2012) Hou-Feng Zheng et al. PLoS Genetics
- Sclerostin: Therapeutic Horizons Based Upon Its Actions
- (2012) Aline G. Costa et al. Current Osteoporosis Reports
- Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia
- (2011) Su Jin Kim et al. HUMAN GENETICS
- Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function
- (2011) Olivier Leupin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
- (2011) Eric Bourhis et al. STRUCTURE
- LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome
- (2010) Yun Li et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis
- (2010) Atsushi Ohazama et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells
- (2010) Jennifer R Stevens et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength
- (2010) Michael S Ominsky et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
- (2010) Mary L Bouxsein et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
- (2010) Michael S Ominsky et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Osteoporosis: impact on health and economics
- (2010) Nicholas Harvey et al. Nature Reviews Rheumatology
- Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome
- (2010) Courtney M. Karner et al. PLoS One
- Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
- (2010) S. A. Ettenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NMR structure of the Wnt modulator protein Sclerostin
- (2009) Stella E. Weidauer et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice
- (2009) Ina Kramer et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
- (2009) Fernando Rivadeneira et al. NATURE GENETICS
- The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations
- (2008) Wendy Balemans et al. CALCIFIED TISSUE INTERNATIONAL
- Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
- (2008) Xiaodong Li et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The Human Combinatorial Antibody Library HuCAL GOLD Combines Diversification of All Six CDRs According to the Natural Immune System with a Novel Display Method for Efficient Selection of High-Affinity Antibodies
- (2008) Christine Rothe et al. JOURNAL OF MOLECULAR BIOLOGY
- LRP4 Serves as a Coreceptor of Agrin
- (2008) Bin Zhang et al. NEURON
- Multiple Genetic Loci for Bone Mineral Density and Fractures
- (2008) Unnur Styrkarsdottir et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development
- (2008) Atsushi Ohazama et al. PLoS One
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started