Article
Endocrinology & Metabolism
Aleksandra Zdrojowy-Welna, Jowita Halupczok-Zyla, Natalia Sloka, Joanna Syrycka, Lukasz Gojny, Marek Bolanowski
Summary: Patients with primary adrenal insufficiency did not show impaired bone status compared to the control group, but had higher sclerostin concentration. The duration of the disease and higher hydrocortisone doses may negatively affect bone status.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Masanori Koide, Teruhito Yamashita, Keigo Nakamura, Hisataka Yasuda, Nobuyuki Udagawa, Yasuhiro Kobayashi
Summary: This study found that approximately two-thirds of bone formation is remodeling-based in Sost-deficient mice, while remodeling-based bone formation accounts for most of the bone formation in Sost(+/-) mice. Anti-RANKL antibody may be useful for detecting modeling-based bone formation on trabecular bone.
Article
Cell & Tissue Engineering
Cassandra R. Diegel, Ina Kramer, Charles Moes, Gabrielle E. Foxa, Mitchell J. Mcdonald, Zachary B. Madaj, Sabine Guth, Jun Liu, Jennifer L. Harris, Michaela Kneissel, Bart O. Williams
Summary: Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Treatment can alleviate symptoms in patients with high bone mass, further confirming the necessity of continuous Wnt production for sustaining high bone mass.
Article
Pharmacology & Pharmacy
Zhijie Dai, Pingfei Fang, Xiang Yan, Ronghua Zhu, Qiong Feng, Qiangyong Yan, Lingfeng Yang, Xiao Fan, Yuting Xie, Lihong Zhuang, Sheng Feng, Yantao Liu, Sheng Zhong, Zeyu Yang, Zhifeng Sheng, Zhiguang Zhou
Summary: SHR-1222, a humanized monoclonal antibody targeting sclerostin, was well tolerated at doses from 50 to 400 mg in this study, showing potential to promote bone formation and reduce bone resorption in individuals with low bone mass.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Igor Gouveia Pietrobom, Ana Cristina Carvalho de Matos, Martin H. H. De Borst, Ita Pfeferman Heilberg
Summary: The study investigated the association of urinary calcium with serum sclerostin, bone mineral density, and body composition in stone formers. The results showed that serum sclerostin is associated with urinary calcium levels, suggesting a potential additional role of sclerostin in calcium reabsorption in the kidneys.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Orlagh Feehan, Pamela Jane Magee, Laura Kirsty Pourshahidi, David John Armstrong, Mary Martina Slevin, Philip James Allsopp, Marie Catherine Conway, J. J. Strain, Emeir Mary McSorley
Summary: The study aimed to investigate the association between n-3 LCPUFA and bone density as well as bone remodeling markers. The results showed no association between n-3 LCPUFA and T-score or BMD, but a significant positive association between total n-3 LCPUFA and femur BMD was observed in women with a low n-6:n-3 ratio. Furthermore, there was a significant inverse association between ALA and urinary DPD/Cr.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Engineering, Biomedical
Daniel de Melo Pereira, Noel Davison, Pamela Habibovic
Summary: Biomineralized collagen composite materials, as an alternative to synthetic bone graft substitutes, offer a biomimetic composition similar to natural bone. In this study, we found phenotypic differences in activity and actin ring formation of human osteoclasts cultured on biomineralized collagen and pure collagen membranes, providing insights for optimized design.
BIOACTIVE MATERIALS
(2022)
Review
Endocrinology & Metabolism
Anna Oniszczuk, Agnieszka Kaczmarek, Mateusz Kaczmarek, Maria Cialowicz, Ersan Arslan, Ana Filipa Silva, Filipe Manuel Clemente, Eugenia Murawska-Cialowicz
Summary: Osteoporosis is a disease characterized by low bone mass and abnormal bone tissue microarchitecture. Exercise can inhibit the secretion of anti-anabolic protein and increase bone mineral density, thus positively impacting osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Ni Su, Cassandra Villicana, Carl Zhang, Jeehee Lee, Sauradeep Sinha, Andrew Yang, Fan Yang
Summary: Mineral particle-coated scaffolds combined with aspirin have a synergistic effect in promoting endogenous bone regeneration and reducing bone resorption. The optimized formulation shows promising potential for repairing critical-sized cranial bone defects.
Review
Biochemistry & Molecular Biology
Karina Akhiiarova, Rita Khusainova, Ildar Minniakhmetov, Natalia Mokrysheva, Anton Tyurin, Giuseppina Storlino
Summary: Peak bone mass refers to the amount of bone tissue formed when a stable skeletal state is achieved at a young age. It plays a crucial role in the prevention of osteoporosis. Factors such as hormonal levels, body composition, physical activity, nutrition, and heredity influence the level of peak bone mass.
Article
Endocrinology & Metabolism
Hai-yan Huang, Zhi-qi Huang, Ling-yan Hua, Wang-shu Liu, Feng Xu, Xiao-qin Ge, Chun-feng Lu, Jian-bin Su, Xue-qin Wang
Summary: The study found a significant association between low-normal serum sodium levels and low bone turnover, as well as a positive correlation between high serum sodium levels and high bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Rossella Tozzi, Davide Masi, Fiammetta Cipriani, Savina Contini, Elena Gangitano, Maria Elena Spoltore, Ilaria Barchetta, Sabrina Basciani, Mikiko Watanabe, Enke Baldini, Salvatore Ulisse, Carla Lubrano, Lucio Gnessi, Stefania Mariani
Summary: This study evaluated the relationship between SIRT1 and sclerostin with bone mass and quality, finding a negative correlation between SIRT1 and bone density, and a negative correlation between sclerostin and bone mass. The results suggest that blood measurement of SIRT1 and sclerostin, taking into account weight and adiposity, can provide a more accurate assessment of bone health.
Article
Endocrinology & Metabolism
Gill Holdsworth, James R. Staley, Peter Hall, Ian van Koeverden, Ciara Vangjeli, Remi Okoye, Rogely W. Boyce, James R. Turk, Martin Armstrong, Alison Wolfreys, Gerard Pasterkamp
Summary: The study showed that most atherosclerotic plaques in patients at risk for cardiovascular disease lacked sclerostin, and its inhibition did not have a significant association with the risk of heart attacks in a population-based cohort study.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Kentaro Matsuzaki, Shahdat Hossain, Harumi Wakatsuki, Yoko Tanabe, Miho Ohno, Setsushi Kato, Osamu Shido, Michio Hashimoto
Summary: A randomized, double-blind, placebo-controlled trial in Japanese adults suggests that long-term intake of perilla seed oil may improve age-related decline in bone mineral density by suppressing bone resorption and increasing alpha-linoleic acid levels.
PHYTOTHERAPY RESEARCH
(2023)
Review
Endocrinology & Metabolism
P. A. Rozenfeld, A. N. Crivaro, M. Ormazabal, J. M. Mucci, C. Bondar, M. V. Delpino
Summary: Gaucher disease is caused by mutations in GBA1 gene, which affects the bone tissue leading to decreased bone density. The mechanism behind reduced bone mineral density in GD is still under debate, with two opposing hypotheses suggesting increased bone resorption or impaired bone formation as the main cause. The imbalance between bone formation and resorption contributes to osteopenia/osteoporosis observed in GD.
MOLECULAR GENETICS AND METABOLISM
(2021)
Article
Anatomy & Morphology
M. Matthijs Fockens, Bernadette S. de Bakker, Roelof-Jan Oostra, Frederik G. Dikkers
Summary: This study investigated the development of tracheal cartilage in healthy human embryos and found that tracheal rings emerge from growth centers in the ventral mesenchyme at approximately 51-54 days of embryological development, indicating a centripetal growth gradient that may contribute to the occurrence of complete tracheal ring deformity.
Article
Medicine, Research & Experimental
Adrianus H. A. Baazil, Erik van Spronsen, Fenna A. Ebbens, Frederik G. Dikkers, Maarten J. F. De Wolf
Summary: The study results indicate that the surgical approach does not have a clinically relevant impact on postoperative pain after ear surgery. However, there are small but statistically significant differences in sleep, normal work, and pain medication usage among different surgical approaches.
Article
Medicine, Research & Experimental
M. Matthijs Fockens, Bernadette S. de Bakker, Krijn P. van Lienden, Frederik G. Dikkers, Carlijn E. L. Hoekstra
Article
Otorhinolaryngology
Adrianus H. A. Baazil, Maura C. Eggink, Maarten J. F. De Wolf, Fenna A. Ebbens, Frederik G. Dikkers, Erik van Spronsen
Summary: The study found no significant difference in identifying the epithelial borders with NBI compared to WLI in cholesteatoma surgery, but subjective assessment suggests a possible benefit of lighting techniques in otology.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Editorial Material
Virology
R. Y. Seedat, F. G. Dikkers
Article
Clinical Neurology
Maura C. Eggink, Maarten J. F. de Wolf, Fenna A. Ebbens, Frederik G. Dikkers, Erik van Spronsen
Summary: This study assessed the prognostic value of the ChOLE classification in predicting the severity of acquired cholesteatoma. The results showed that the classification did not predict residual or recurrent disease, nor the occurrence of adverse events (AE). However, risk factors for severe cholesteatoma were identified, which could be useful for the development of future classifications.
OTOLOGY & NEUROTOLOGY
(2022)
Review
Virology
Malgorzata Wierzbicka, Michel R. M. San Giorgi, Frederik G. Dikkers
Summary: This article examines the prevalence and routes of transmission of human papillomavirus (HPV) through a narrative review of the literature. The study suggests that HPV is mainly transmitted to the oral cavity and oropharynx through sexual contact, while transmission through saliva and daily activities is not a significant source of infection. Survivors of oropharyngeal HPV-related cancer and their partners do not have an increased risk of infection during sexual intercourse.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Otorhinolaryngology
Louis Pogoda, Fuat Ziylan, Diederik P. J. Smeeing, Frederik G. Dikkers, Rico N. P. M. Rinkel
Summary: Systemic and intralesional administration of bevacizumab are effective treatment options for severe RRP. Systemic administration may be the preferred choice of treatment.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Leonie G. M. Wijermars, Carlijn E. L. Hoekstra, Thao T. T. Nguyen, Markus F. Stevens, Frederik G. Dikkers
Article
Medicine, Research & Experimental
Craig S. Derkay, Emily E. Wikner, Seth Pransky, Simon R. Best, Karen Zur, Douglas R. Sidell, Adam Klein, Clark Rosen, Frederick G. Dikkers, Romaine Johnson
Article
Medicine, General & Internal
Ashna I. E. Ramautar, Cornelie D. Andela, Neveen A. T. Hamdy, Elizabeth M. Winter, Natasha M. Appelman-Dijkstra
Summary: This study evaluated the impact of sternocostoclavicular hyperostosis (SCCH), the main clinical manifestation of chronic non-bacterial osteomyelitis (CNO) in adults, on quality of life (QoL) and identified its determinants. The study found that patients with CNO/SCCH demonstrated significant impairments in multiple aspects of QoL, maladaptive illness perceptions, and ineffective coping strategies. Higher pain scores and limited shoulder function were identified as determinants for impaired QoL in patients with a >5-year delay in diagnosis. The study suggests that shortening delay in diagnosis, effective pain management, and psychosocial interventions targeting these factors can help minimize the negative impact of CNO/SCCH on QoL.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Frederik G. Dikkers, Michel R. M. San Giorgi, Rico N. P. M. Rinkel, Marc Remacle, Antoine Giovanni, Malgorzata Wierzbicka, Riaz Seedat, Guillermo Campos, Guri S. Sandhu
Summary: Informed consent is crucial for surgical interventions, including suspension microlaryngoscopy (SML). This study examines informed consent procedures in nine countries and identifies various risks associated with SML. The study concludes that SML is a safe procedure with low morbidity and provides recommendations for informed consent.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Biographical-Item
Otorhinolaryngology
Frederik G. Dikkers, Marc Remacle, Yakubu Karagama
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Anusha Ponduri, Monica C. C. Azmy, Eden Axler, Juan Lin, Rachel Schwartz, Magdalena Chirila, Frederik G. G. Dikkers, Christina J. J. Yang, Vikas Mehta, Mona Gangar
Summary: The efficacy of HPV vaccination as an adjuvant therapy in recurrent respiratory papillomatosis (RRP) was characterized through a systematic review and meta-analysis of 13 studies. The addition of HPV vaccination was associated with increased intervals between surgeries and decreased number of surgical procedures required. This suggests that HPV vaccination may be a beneficial adjuvant treatment for RRP.
Editorial Material
Otorhinolaryngology
Frederik G. Dikkers
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2023)