Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling
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Title
Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling
Authors
Keywords
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Journal
JOURNAL OF CELL BIOLOGY
Volume 216, Issue 3, Pages 761-778
Publisher
Rockefeller University Press
Online
2017-02-13
DOI
10.1083/jcb.201608002
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Note: Only part of the references are listed.- A Novel Domain-Specific Mutation in a Sclerosteosis Patient Suggests a Role of LRP4 as an Anchor for Sclerostin in Human Bone
- (2016) Igor Fijalkowski et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System
- (2016) F. Trepiccione et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Role of Wnt/β-catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients
- (2015) Agnetha Folestad et al. Acta Orthopaedica
- LRP4 in neuromuscular junction and bone development and diseases
- (2015) Chengyong Shen et al. BONE
- Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass
- (2015) Zachary C. Ryan et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption
- (2015) Lei Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-3, Shears for Synapse Pruning
- (2014) Chengyong Shen et al. DEVELOPMENTAL CELL
- CD73-Generated Adenosine Is Critical for Immune Regulation during Toxoplasma gondii Infection
- (2014) Deeqa A. Mahamed et al. INFECTION AND IMMUNITY
- P2X4 Forms Functional ATP-activated Cation Channels on Lysosomal Membranes Regulated by Luminal pH
- (2014) Peng Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SLC17A9 Protein Functions as a Lysosomal ATP Transporter and Regulates Cell Viability
- (2014) Qi Cao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nucleotide signalling during inflammation
- (2014) Marco Idzko et al. NATURE
- Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels
- (2014) Ming-Kang Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells
- (2014) Erina Takai et al. Purinergic Signalling
- Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation
- (2013) Aránzazu Mediero et al. BRITISH JOURNAL OF PHARMACOLOGY
- (Pro)renin receptor and V-ATPase: fromDrosophilato humans
- (2013) Anthony Rousselle et al. CLINICAL SCIENCE
- Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling
- (2013) Y. Ahn et al. DEVELOPMENT
- Cenani–Lenz syndrome restricted to limb and kidney anomalies associated with a novel LRP4 missense mutation
- (2013) Tahir Naeem Khan et al. European Journal of Medical Genetics
- In Vivo Overexpression of Tissue-Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of Osteopontin
- (2013) Sonoko Narisawa et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling
- (2013) Wen-Fang Xia et al. JOURNAL OF CELL BIOLOGY
- The vesicular ATPase: A missing link between acidification and exocytosis
- (2013) Dong Wang et al. JOURNAL OF CELL BIOLOGY
- WNT signaling in bone homeostasis and disease: from human mutations to treatments
- (2013) Roland Baron et al. NATURE MEDICINE
- Extracellular ATP Released by Osteoblasts Is A Key Local Inhibitor of Bone Mineralisation
- (2013) Isabel R. Orriss et al. PLoS One
- Purinergic signalling in the musculoskeletal system
- (2013) Geoffrey Burnstock et al. Purinergic Signalling
- Adenosine and bone metabolism
- (2013) Aránzazu Mediero et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Structural basis of agrin-LRP4-MuSK signaling
- (2012) Y. Zong et al. GENES & DEVELOPMENT
- Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation
- (2012) Haitao Wu et al. NEURON
- Adenosine A2A Receptor Ligation Inhibits Osteoclast Formation
- (2011) Aránzazu Mediero et al. AMERICAN JOURNAL OF PATHOLOGY
- Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID
- (2011) A. V. Sauer et al. BLOOD
- Foreword: Bisphosphonates
- (2011) David Burr et al. BONE
- Bisphosphonates: The first 40years
- (2011) R. Graham G. Russell BONE
- Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function
- (2011) Olivier Leupin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF- -Mediated Bone Loss
- (2011) M. M. Zaiss et al. JOURNAL OF IMMUNOLOGY
- Matrix-embedded cells control osteoclast formation
- (2011) Jinhu Xiong et al. NATURE MEDICINE
- Evidence for osteocyte regulation of bone homeostasis through RANKL expression
- (2011) Tomoki Nakashima et al. NATURE MEDICINE
- Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway
- (2011) Asiri R. Wijenayaka et al. PLoS One
- Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration
- (2011) Patrick M Chen et al. Cell and Bioscience
- Denosumab and bisphosphonates: Different mechanisms of action and effects
- (2010) Roland Baron et al. BONE
- Renin, (pro)renin and receptor: an update
- (2010) Genevieve Nguyen CLINICAL SCIENCE
- Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor
- (2010) Tina Buechling et al. CURRENT BIOLOGY
- To build a synapse: signaling pathways in neuromuscular junction assembly
- (2010) H. Wu et al. DEVELOPMENT
- Regulatory Mechanism of Osteoclastogenesis by RANKL and Wnt Signals
- (2010) Naoyuki Takahashi Frontiers in Bioscience-Landmark
- Involvement of SLC17A9-dependent Vesicular Exocytosis in the Mechanism of ATP Release during T Cell Activation
- (2010) Akihiro Tokunaga et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling
- (2010) C.-M. Cruciat et al. SCIENCE
- The Mechanism of Mineralization and the Role of Alkaline Phosphatase in Health and Disease
- (2010) Hideo Orimo JOURNAL OF NIPPON MEDICAL SCHOOL
- Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells
- (2009) Domenick A. Prosdocimo et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Hypoxia stimulates vesicular ATP release from rat osteoblasts
- (2009) Isabel R. Orriss et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo
- (2009) Hong Y. Choi et al. PLoS One
- Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK
- (2008) Natalie Kim et al. CELL
- LRP4 Serves as a Coreceptor of Agrin
- (2008) Bin Zhang et al. NEURON
- Vesicular ATP transport is a hard (V)NUT to crack
- (2008) G. Rudnick PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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