Article
Horticulture
Xiangli Sun, Zebin Yuan, Bo Wang, Liping Zheng, Jianzhong Tan
Summary: The study found that exogenous putrescine (Put) has positive effects on the chilling tolerance of Anthurium andraeanum. Pretreatment of anthurium seedlings with Put resulted in the accumulation of endogenous NO, with the NOS-dependent pathway playing a vital role in its generation. The NOS-dependent pathway was identified as the primary source of endogenous NO in Put-pretreated anthurium.
SCIENTIA HORTICULTURAE
(2023)
Article
Multidisciplinary Sciences
Grzegorz A. Czapski, Magdalena Cieslik, Emilia Bialopiotrowicz, Walter J. Lukiw, Joanna B. Strosznajder
Summary: The study found that both amyloid beta and inflammation significantly decreased the expression of cyclin D2, suggesting that amyloid beta may also contribute to the downregulation of cyclin D2 in Alzheimer's disease brain.
Article
Biochemistry & Molecular Biology
Emilio Bueno, Daniel Mania, Socorro Mesa, Eulogio J. Bedmar, Asa Frostegard, Lars R. Bakken, Maria J. Delgado
Summary: The paper investigates the nitrogen-fixing ability of Bradyrhizobium diazoefficiens, a symbiotic bacterium found in soybeans. It explores the regulatory mechanisms and factors affecting nitrogen fixation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ludan Hou, Mengran Zhao, Chenyang Huang, Qi He, Lijiao Zhang, Jinxia Zhang
Summary: This study demonstrates that the aox gene in P. ostreatus mycelia can be induced by NO under HS, regulating the TCA cycle and cell respiration to reduce ROS production, and mediating the retrograde signaling pathway in the mycelial response to HS.
MICROBIAL CELL FACTORIES
(2021)
Article
Pharmacology & Pharmacy
Soshi Narasaki, Soma Noguchi, Tomoaki Urabe, Kana Harada, Izumi Hide, Shigeru Tanaka, Yuhki Yanase, Taketoshi Kajimoto, Kazue Uchida, Yasuo M. Tsutsumi, Norio Sakai
Summary: The aim of this study was to identify the PKC domains involved in propofol-induced PKC translocation. The results showed that the C1 and C2 domains of PKCα and the C1B domain of PKC8 are involved in propofol-induced PKC translocation. In addition, the C1 domain inhibitor calphostin C inhibited propofol-induced PKC8 translocation and phosphorylation of endothelial nitric oxide synthase.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agronomy
Jialiang Liu, Wanli Zhang, Meijiao Hu, Yonggui Pan, Yueming Jiang, Zhengke Zhang, Guoxiang Jiang
Summary: This study investigates the interplay between melatonin and nitric oxide (NO) in relation to cold stress tolerance in litchi fruit. The results show that melatonin triggers NO accumulation by activating nitric oxide synthase (NOS) and nitrate reductase (NR) in refrigerated litchi fruit, improving cold tolerance. Melatonin also reduces reactive oxygen species (ROS) accumulation and increases antioxidant activity, protecting membrane integrity. However, the effect of melatonin is partially counteracted by the NO scavenger cPTIO.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Valeria Conti, Joseph Iharinjaka Randriamboavonjy, Herintsoa Rafatro, Valentina Manzo, Jessica Dal Col, Amelia Filippelli, Graziamaria Corbi, Angela Tesse
Summary: Vascular aging is associated with various factors such as reduced NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. This study investigated the effect of MOI on vascular improvement in middle-aged rats and its involvement of SIRT1. The results showed that MOI treatment enhanced SIRT1 expression and activity, reduced oxidative stress, and reversed FOXO1 expression in the aorta, suggesting its protective role against cardiovascular dysfunction due to aging.
Article
Gastroenterology & Hepatology
Yang Shen, Francesca Cingolani, Shoaib Ahmad Malik, Jing Wen, Yunshan Liu, Mark J. Czaja
Summary: Decreased hepatocyte autophagy sensitizes mice to IFN gamma-induced liver injury and inflammation through overactivation of STAT1 signaling that causes NOS2 overexpression. Hepatotoxicity is restricted to female mice, suggesting that sex-specific effects of defective autophagy may underlie the increased susceptibility of females to IFN gamma-mediated immune diseases.
Article
Multidisciplinary Sciences
Yann D. Ladner, Angela R. Armiento, Eva J. Kubosch, Jess G. Snedeker, Martin J. Stoddart
Summary: Tissue engineering combines cells and biomaterials to treat orthopedic pathologies. Mechanical stimulation plays a crucial role in stem cell differentiation, but the interaction between different mechanical loading parameters is still unclear. In this study, we used a full factorial design of experiment to investigate the effect of different mechanical loading parameters on biological markers, and employed novel statistical methods for data analysis.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Inesa Navasardyan, Benjamin Bonavida
Summary: The T cell-mediated immune response plays a key role in combating infectious diseases and cancer, with complex underlying mechanisms. The iNOS/.NO mechanism regulates various cells and tissues that control the anti-tumor T cell response. The concentration and exposure time of .NO can have different effects on immune responses mediated by T cells.
Article
Immunology
Jingxue Wu, Yongwu Yang, Lin Liu, Weining Zhu, Min Liu, Xiran Yu, Wei Li
Summary: Giardia duodenalis is a common parasitic protozoan that infects the upper small intestine and causes giardiasis, a common gastrointestinal disease. This study found that Giardia infection can induce autophagy in intestinal epithelial cells (IECs), and that autophagy is associated with the pathogenesis of giardiasis, including tight junction defects and NO release.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yanwen Zhang, Zefeng Wang, Mei Li, Can Xu, Ning Gao, Zhuping Yin, Kemin Wang, Stephen Mann, Jianbo Liu
Summary: The design and construction of synthetic protocells capable of stimuli response and homeostatic regulation is an important challenge for synthetic protobiology. In this study, we demonstrate a reconfigurable model protocell based on osmotic reconfiguration of lipid-coated coacervate droplets into multicompartmentalized coacervate vesicles that can exhibit hypotonic stress-induced volume response and enhance enzyme reactions. The increased nitric oxide (NO) within the swollen vesicles can induce blood vessel vasodilation, showing potential applications in biomedicine, cellular diagnostics, and bioengineering.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Agronomy
Yanjun Zhang, Yongjiang Zhang, Guangya Liu, Shizhen Xu, Jianlong Dai, Weijiang Li, Zhenhuai Li, Dongmei Zhang, Cundong Li, Hezhong Dong
Summary: The study found that increasing NO concentrations in plant tissues through foliar application of SNP can alleviate waterlogging stress, ultimately reducing biological and lint yield loss.
FIELD CROPS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sergei Korneev, Jekaterina Garaliene, Gabriella Taylor, Ildiko Kemenes, Gyorgy Kemenes
Summary: Long natural antisense transcripts (NATs) are prevalent in eukaryotic organisms, particularly in the nervous system; Lym-NOS1AS is co-expressed with Lym-NOS1 mRNA in a key neuron of the memory network; Lym-NOS1AS plays a crucial role in nitric oxide-dependent long-term memory consolidation and is regulated by one-trial conditioning.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Slobodan Tepic, Daniel Arens, Tim Buchholz, Dirk Nehrbass, Olivera Cvetkovic, Martin J. Stoddart, R. G. Richards, Stephan Zeiter
Summary: Pneumonia, especially during the COVID-19 pandemic, has become a major public health and economic disaster. This study suggests that lung metabolism in inflammation may have common features regardless of the underlying cause. By comparing mice with bleomycin-induced lung inflammation to control groups, it was found that certain amino acids had significantly lower concentrations in the arterial blood, indicating that arginine replacement therapy may be beneficial in pneumonia.
Article
Endocrinology & Metabolism
Flor M. Perez-Campo, Tobias May, Jeannette Zauers, Carolina Sanudo, Jesus Delgado-Calle, Jana Arozamena, Maria T. Berciano, Miguel Lafarga, Jose A. Riancho
JOURNAL OF BONE AND MINERAL METABOLISM
(2017)
Article
Endocrinology & Metabolism
Jesus Delgado-Calle, Xiaolin Tu, Rafael Pacheco-Costa, Kevin McAndrews, Rachel Edwards, Gretel G. Pellegrini, Kali Kuhlenschmidt, Naomie Olivos, Alexander Robling, Munro Peacock, Lilian I. Plotkin, Teresita Bellido
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Editorial Material
Endocrinology & Metabolism
Jesus Delgado-Calle
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Benjamin Hancock, Elive F. Likine, Amy Y. Sato, Kevin McAndrews, Carolina Sanudo, Angela Bruzzaniti, Jose A. Riancho, James R. Tonra, Teresita Bellido
Article
Dentistry, Oral Surgery & Medicine
J. Chen, X. Yuan, I. Pilawski, X. Liu, J. Delgado-Calle, T. Bellido, H. Turkkahraman, J. A. Helms
Summary: Genetic disorders can result in distinctive facial features, affecting diagnosis and treatment. Using a mouse model, this study found that mutations in the Sost gene led to abnormal bone growth, causing changes in facial skeletal morphology and size, suggesting a role for sclerostin signaling in modulating craniofacial morphology.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Patrick L. Mulcrone, Shanique K. E. Edwards, Daniela N. Petrusca, Laura S. Haneline, Jesus Delgado-Calle, G. David Roodman
SCIENTIFIC REPORTS
(2020)
Review
Endocrinology & Metabolism
Manish Adhikari, Jesus Delgado-Calle
Summary: Cancer cells manipulate osteocytes to facilitate invasion and tumor progression in bone, disrupting physiological bone remodeling and leading to bone diseases. Targeting osteocytes and their derived factors has been shown to effectively interfere with the progression of cancer in the bone. The interaction between osteocytes and cancer cells is complex and further research is needed to understand it better.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Oncology
Hayley M. Sabol, Adam J. Ferrari, Manish Adhikari, Tania Amorim, Kevin McAndrews, Judith Anderson, Michele Vigolo, Rajwinder Lehal, Meloney Cregor, Sharmin Khan, Pedro L. Cuevas, Jill A. Helms, Noriyoshi Kurihara, Venkat Srinivasan, Frank H. Ebetino, Robert K. Boeckman, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Summary: The development of a bone-targeted Notch inhibitor, BT-GSI, reduces tumor burden in multiple myeloma and effectively prevents cancer-induced bone destruction without causing the gastrointestinal toxicity associated with conventional Notch inhibitors.
Review
Physiology
Jesus Delgado-Calle, Teresita Bellido
Summary: Osteocytes are multifunctional cells that can regulate bone homeostasis and play a role in various disorders affecting the skeleton. They are also targets and distributors of novel therapies.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Review
Oncology
Aric Anloague, Jesus Delgado-Calle
Summary: The tumor microenvironment in the bone plays a crucial role in the initiation and progression of cancer. Specifically, the interactions between cancer cells and bone cells, particularly osteocytes, have been identified as key factors in tumor growth and bone disease. Understanding the reciprocal crosstalk between these cells may lead to the development of novel therapeutic strategies for treating bone cancer.
Article
Biochemistry & Molecular Biology
Daniel Garcia-Sanchez, Alberto Gonzalez-Gonzalez, Itziar Alvarez-Iglesias, Monica del Dujo-Gutierrez, Alfonso Bolado-Carrancio, Matilde Certo, Maria Isabel Perez-Nunez, Jose A. Riancho, Jose Carlos Rodriguez-Rey, Jesus Delgado-Calle, Flor Maria Perez-Campo
Summary: The secretome from MSCs in which Sfrp1 has been silenced shows positive effects on bone regeneration by enhancing osteogenic differentiation, decreasing the expression of Wnt inhibitor Dkk1, and inhibiting osteoclastogenesis. The secretome also increases mineralization in human primary MSCs from osteoporotic patients. Proteomic analysis reveals enrichment of osteogenesis-related proteins in the secretome, suggesting that this approach can enhance the osteo-regenerative properties of MSCs' secretome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Kazuaki Miyagawa, Yasuhisa Ohata, Jesus Delgado-Calle, Jumpei Teramachi, Hua Zhou, David D. Dempster, Mark A. Subler, Jolene J. Windle, John M. Chirgwin, G. David Roodman, Noriyoshi Kurihara
Article
Endocrinology & Metabolism
Emily G. Atkinson, Jesus Delgado-Calle
Review
Endocrinology & Metabolism
Teresita Bellido, Jesus Delgado-Calle