Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

Genetic variants influencing phenotypic variance heterogeneity

(2018) Weronica E Ek et al.   HUMAN MOLECULAR GENETICS

Pervasive Modulation of Obesity Risk by the Environment and Genomic Background

(2018) Sini Nagpal et al.   Genes

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Identifying loci affecting trait variability and detecting interactions in genome-wide association studies

(2018) Alexander I. Young et al.   NATURE GENETICS

A linear mixed-model approach to study multivariate gene–environment interactions

(2018) Rachel Moore et al.   NATURE GENETICS

Genotype–covariate interaction effects and the heritability of adult body mass index

(2017) Matthew R Robinson et al.   NATURE GENETICS

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

(2017) Louise V Wain et al.   NATURE GENETICS

Embracing polygenicity: a review of methods and tools for psychiatric genetics research

(2017) R. M. Maier et al.   PSYCHOLOGICAL MEDICINE

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data

(2016) Huwenbo Shi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations

(2016) Sara L. Pulit et al.   GENETIC EPIDEMIOLOGY

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Selection on noise constrains variation in a eukaryotic promoter

(2015) Brian P. H. Metzger et al.   NATURE

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Another explanation for apparent epistasis

(2014) Andrew R. Wood et al.   NATURE

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

What Is the Significance of Difference in Phenotypic Variability across SNP Genotypes?

(2013) Xiangqing Sun et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity

(2013) Ying Cao et al.   GENETIC EPIDEMIOLOGY

The bigger picture of FTO—the first GWAS-identified obesity gene

(2013) Ruth J. F. Loos et al.   Nature Reviews Endocrinology

Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

(2013) Jian Yang et al.   PLoS Genetics

Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability

(2012) Lars Rönnegård et al.   BMC GENETICS

CHRNA3genotype, nicotine dependence, lung function and disease in the general population

(2012) Diljit Kaur-Knudsen et al.   EUROPEAN RESPIRATORY JOURNAL

Challenges and opportunities in genome-wide environmental interaction (GWEI) studies

(2012) Hugues Aschard et al.   HUMAN GENETICS

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus

(2012) Carolina Medina-Gomez et al.   PLoS Genetics

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Detecting Major Genetic Loci Controlling Phenotypic Variability in Experimental Crosses

(2011) Lars Rönnegård et al.   GENETICS

Genetic analysis of environmental variation

(2011) WILLIAM G. HILL et al.   Genetics Research

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

(2011) Christie D. Fowler et al.   NATURE

Genome partitioning of genetic variation for complex traits using common SNPs

(2011) Jian Yang et al.   NATURE GENETICS

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations

(2010) Maksim V Struchalin et al.   BMC GENETICS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Gene–environment-wide association studies: emerging approaches

(2010) Duncan Thomas   NATURE REVIEWS GENETICS

On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study

(2010) Guillaume Paré et al.   PLoS Genetics

Rank-Based Inverse Normal Transformations are Increasingly Used, But are They Merited?

(2009) T. Mark Beasley et al.   BEHAVIOR GENETICS

Genome-wide association study identifies five loci associated with lung function

(2009) Emmanouela Repapi et al.   NATURE GENETICS

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

(2009) Dana B Hancock et al.   NATURE GENETICS

Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip

(2009) Chris C. A. Spencer et al.   PLoS Genetics

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE