Article
Pharmacology & Pharmacy
Jing Liu, Xuehui Zheng, Chen Zhang, Chunmei Zhang, Peili Bu
Summary: The study demonstrated that ARNI alleviated myocardial fibrosis by inhibiting the Wnt/beta-catenin signaling pathway and overexpressing sFRP-1, thereby improving cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Xingren Chen, Xiaobo Zhu, Ai Wei, Fang Chen, Qi Gao, Ke Lu, Qing Jiang, Wangsen Cao
Summary: Epigenetic derepression of Nrf2 plays a critical role in the pathogenesis of osteoporosis, and running exercise can correct this process to improve bone density. Exercise also regulates the expression of other osteogenic factors and improves bone mass and microstructure.
Article
Biochemistry & Molecular Biology
Cuidi Xu, Hongli Shi, Xin Jiang, Yongqian Fan, Donghui Huang, Xinming Qi, Qun Cheng
Summary: ZEB1 is a key transcription factor in BMSC differentiation, playing a crucial role in maintaining bone health. Silencing ZEB1 can enhance osteogenesis and inhibit bone loss.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Genetics & Heredity
Ankita Sharma, Rafeeq Mir, Sanjeev Galande
Summary: This review discusses the role of the Wnt/beta-catenin pathway in cell proliferation, differentiation, and migration, as well as its impact on embryonic development, tissue regeneration, and cancer. It highlights the influence of epigenetic factors on the pathway and the crosstalk with other signaling pathways, particularly the Hippo/YAP pathway. The review also emphasizes recent advances in developing potential therapeutic interventions targeting the epigenetic machinery for treating various cancers and regenerative therapies.
FRONTIERS IN GENETICS
(2021)
Article
Hematology
Yi Gong, Xinhua Zhang, Qianqian Zhang, Yanxia Zhang, Yuhua Ye, Wenxia Yu, Congwen Shao, Tizhen Yan, Jin Huang, Jianmei Zhong, Li Wang, Yaoyun Li, Liren Wang, Xiangmin Xu
Summary: The study identified a novel DNMT1 mutation (S878F) which affects DNMT1 phosphorylation, stability, and interactions with other proteins, resulting in epigenetic derepression of gamma-globin expression. This mutation was found to modulate fetal hemoglobin synthesis and could potentially be a new therapeutic target for beta-hemoglobinopathies.
Article
Pharmacology & Pharmacy
Shuyuan Li, Hongliang Zhou, Cheng Hu, Jiabao Yang, Jinfei Ye, Yuexi Zhou, Zige Li, Leilei Chen, Qishi Zhou
Summary: Total flavonoids of Rhizoma drynariae (TFRD) can promote mineralization of bone graft and differentiation of osteoblasts in Masquelet induced membrane technique in rats, which is partly related to the activation of Wnt/beta-catenin signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: The study reveals that Qishen Yiqi dripping pill exerts renal-protective function by inhibiting the Wnt/beta-catenin and TGF-beta/Smad2 signaling pathways in diabetic rats, as evidenced by reduced levels of serum markers and improved kidney histology and fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little III, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz M. P. Mariani, Larissa Costa Amorim, Ana Claudia Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K. N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida Barisson Villares Fragoso, David T. Breault, Antonio Marcondes Lerario, Gary D. Hammer
Summary: In adrenocortical carcinoma, 3-catenin regulates cellular differentiation and cancer growth by binding with SF1 and EZH2. Inhibiting EZH2 reverses differentiation and restrains cancer growth.
Article
Biotechnology & Applied Microbiology
Jie Gao, Jiayuan Zhang, Lianheng Xia, Xuewei Liang, Wukun Ding, Meiyu Song, Linggen Li, Zhen Jia
Summary: Chitosan up-regulates CAV1 expression and promotes canonical Wnt signaling pathway activity, providing pharmacological effects on wound healing and angiogenesis.
Article
Orthopedics
Lu Gan, Zhonghao Deng, Yiran Wei, Hongfang Li, Liang Zhao
Summary: The study found that GEM expression decreased in cartilage tissues of OA patients and OA mimic chondrocytes, but increased during chondrogenesis and cartilage matrix formation. Silencing GEM suppressed chondrogenic differentiation and specific gene expressions, with the Wnt signaling pathway playing a crucial role.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Wenchao Hu, Rui Wang, Bei Sun
Summary: Metrnl improves beta cell function by inhibiting beta cell apoptosis and promoting beta cell proliferation, activating the WNT/beta-catenin pathway. In experiments, Metrnl reversed the apoptosis of MIN6 cells and inhibition of beta cell proliferation induced by high glucose.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Minfeng Wu, Jianhua Huang, Jingjuan Shi, Lei Shi, Qingyu Zeng, Hongwei Wang
Summary: Ruyi Jinhuang Powder (RJP) has significant therapeutic effects on diabetic ulcers as it promotes fibroblast proliferation and migration through activating Wnt/beta-catenin signaling pathway. In addition, RJP reduces inflammation and improves wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhaohua Yang, Jinying Wei, Yashu Wang, Yunxia Du, Shan Song, Jiawei Li, Ziyuan Su, Yonghong Shi, Haijiang Wu
Summary: This study aimed to investigate the role of irisin in diabetic kidney disease (DKD) and analyze its effects in vitro and in vivo. The results showed that irisin reduced tubulointerstitial fibrosis (TIF) in diabetic mice by regulating the Smad4/beta-catenin signaling pathway. This study revealed the potential of irisin as a therapeutic target for DKD.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Dan Xiong, Wei Hu, Xiaofang Han, Yahong Cai
Summary: This study found that rhein inhibited oxidative stress and podocyte injury induced by high glucose, attenuating diabetic nephropathy by regulating the Rac1/NOX1/beta-catenin axis.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Medicine, Research & Experimental
Wenbei Ma, Zhengyuan Xie, Hui Chen, Lina Zeng, Xiaohong Chen, Songfu Feng, Xiaohe Lu
Summary: High glucose levels in diabetic corneal epithelial cells lead to abnormalities in cell junctions, with decreased E-cadherin expression and increased levels of beta-catenin in the nucleus. This disruption of the beta-catenin/E-cadherin complex promotes nuclear translocation of beta-catenin and activates the transcription and expression of matrix metallopeptidase and snail, interfering with cell adhesion. Targeting the stability of the beta-catenin/E-cadherin complex may provide a potential therapeutic approach for refractory corneal ulcers in diabetic patients.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Kazufumi Tanigawa, Masashi Maekawa, Takeshi Kiyoi, Jun Nakayama, Riko Kitazawa, Sohei Kitazawa, Kentaro Semba, Tomohiko Taguchi, Satoshi Akita, Motohira Yoshida, Kei Ishimaru, Yuji Watanabe, Shigeki Higashiyama
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Ryuma Haraguchi, Riko Kitazawa, Yukihiro Kohara, Aoi Ikedo, Yuuki Imai, Sohei Kitazawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Yukihiro Kohara, Ryuma Haraguchi, Riko Kitazawa, Sohei Kitazawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Ryuma Haraguchi, Yukihiro Kohara, Kanako Matsubayashi, Riko Kitazawa, Sohei Kitazawa
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2020)
Article
Biochemistry & Molecular Biology
Yukihiro Kohara, Ryuma Haraguchi, Riko Kitazawa, Yuuki Imai, Sohei Kitazawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cardiac & Cardiovascular Systems
Shungo Yukumi, Hideaki Suzuki, Masamitsu Morimoto, Hisayuki Shigematsu, Ryujiro Sugimoto, Nobuhiko Sakao, Masahiro Abe, Akira Watanabe, Sohei Kitazawa, Yoshifumi Sano
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Letter
Hematology
Yuichi Ikeda, Kazushi Tanimoto, Taichi Azuma, Hiroshi Fujiwara, Toshiki Ochi, Hiroaki Asai, Shogo Nabe, Masaki Maruta, Kazuto Takeuchi, Jun Yamanouchi, Sohei Kitazawa, Katsuto Takenaka
ANNALS OF HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yukihiro Kohara, Sohei Kitazawa, Riko Kitazawa, Ryuma Haraguchi, Kiyotaka Arai, Hajime Amasaki, Satoshi Soeta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Ryuma Haraguchi, Gen Yamada, Aki Murashima, Daisuke Matsumaru, Riko Kitazawa, Sohei Kitazawa
Summary: The development of the female reproductive tract in mammals relies on the interaction between Wolffian ducts (WDs) and Mullerian ducts (MDs), regulated by Hedgehog (Hh) signaling. Deficiency of Sonic hedgehog (Shh), exclusively expressed in WDs, prevents the MD mesenchyme from affecting uterine growth. In vivo cell tracking reveals that cells responding to WD-derived Hh signal continue to contribute to the formation of various tissues in the developing female reproductive tract.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sohei Kitazawa, Yuki Takaoka, Yasuo Ueda, Riko Kitazawa
Summary: The study identified CALML5 as an important protein in squamous epithelial cell structures, with potential implications for cervical cancer. The regulation of CALML5 involves the transcription factors ZNF750 and KLF4 through their nuclear translocation. Changes in CALML5 expression levels during cancer progression could serve as a diagnostic marker for differentiating cervical cancer stages.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Riko Kitazawa, Ryuma Haraguchi, Yukihiro Kohara, Sohei Kitazawa
Summary: The RANK receptor regulates the differentiation and function of osteoclasts through direct binding of NFATc1. The RANKL signal positively regulates RANK transcription, promoting accelerated terminal differentiation of osteoclast precursors to mature osteoclasts.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa
Summary: Macrophages play a crucial role in bone regeneration by promoting angiogenesis and wound healing. Through RNA-seq analysis, TGFBI, uPA, and TGF-beta 1 secreted by macrophages were identified as genes mediating angiogenesis and wound healing. Treatment with uPA inhibitor or TGF-beta receptor inhibitors confirmed their importance in bone regeneration.
Article
Cell Biology
Sohei Kitazawa, Ryuma Haraguchi, Yuki Takaoka, Riko Kitazawa
Summary: This article introduces a novel histochemical technique that allows for the observation of sequence-specific DNA methylation status while maintaining tissue architecture. By optimizing the treatment conditions, it is possible to selectively detect the presence of a single methylated cytosine in individual cells.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Letter
Pathology
Sohei Kitazawa, Riko Kitazawa
PATHOLOGY INTERNATIONAL
(2023)
Letter
Pathology
Sohei Kitazawa, Riko Kitazawa
PATHOLOGY INTERNATIONAL
(2023)