Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function

Molecular Mechanisms in Coupling of Bone Formation to Resorption

(2012) T. John Martin et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome

(2010) Yun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic evidence that SOST inhibits WNT signaling in the limb

(2010) Nicole M. Collette et al.   DEVELOPMENTAL BIOLOGY

Sclerostin: A gem from the genome leads to bone-building antibodies

(2010) Chris Paszty et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Local communication on and within bone controls bone remodeling

(2009) Kim Henriksen et al.   BONE

Genetics of osteoporosis: accelerating pace in gene identification and validation

(2009) Wen-Feng Li et al.   HUMAN GENETICS

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Osteocyte-Derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt Signaling

(2008) Peter ten Dijke et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

New sequence variants associated with bone mineral density

(2008) Unnur Styrkarsdottir et al.   NATURE GENETICS

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON

Multiple Genetic Loci for Bone Mineral Density and Fractures

(2008) Unnur Styrkarsdottir et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development

(2008) Atsushi Ohazama et al.   PLoS One