Article
Endocrinology & Metabolism
Daniela Schnyder, Giuseppe Albano, Patrycja Kucharczyk, Silvia Dolder, Mark Siegrist, Manuel Anderegg, Ganesh Pathare, Willy Hofstetter, Roland Baron, Daniel G. Fuster
Summary: Mutations in the SLC9A6 gene encoding NHE6 can lead to severe X-linked mental retardation, epilepsy, autism, and skeletal malformations in humans. Knocking out the NHE6 gene in mice caused reduced bone volume, trabecular number, and bone formation, associated with an increase in sclerostin expression.
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Review
Biochemistry & Molecular Biology
Yongguang Gao, Suryaji Patil, Jingxian Jia
Summary: Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tobias M. Ballhause, Shan Jiang, Anke Baranowsky, Sabine Brandt, Peter R. Mertens, Karl-Heinz Frosch, Timur Yorgan, Johannes Keller
Summary: Notch1-4 receptors and their signaling pathways are crucial in cell fate decision by coordinating cell proliferation, differentiation and apoptosis, with differential expression and activation observed in various organs and tissues. In bone, Notch receptors control remodeling and regeneration, with distinct expression and function depending on differentiation stages. The crosstalk between Notch signaling and other pathways in bone turnover, including Wnt/beta-catenin, BMP and RANKL/OPG, is outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Muhamed Lahtif Nor Muhamad, Sophia Ogechi Ekeuku, Sok-Kuan Wong, Kok-Yong Chin
Summary: This systematic review presents the available evidence on the skeletal protective effects of naringenin, a natural compound found in citrus fruits and grapefruit. The findings suggest that naringenin enhances bone formation and inhibits bone resorption through various signaling pathways, making it a potential dietary intervention for preventing bone loss.
Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tsutomu Takeuchi, Hiroto Yoshida, Sakae Tanaka
Summary: Rheumatoid arthritis is a common inflammatory form of arthritis closely associated with bone-related cells and inflammatory cytokines. Inhibition of disease progression and joint destruction has become an important clinical goal in the treatment of RA. Recent studies have shown that drug intervention targeting proinflammatory cytokines like IL-6 can not only suppress bone and joint destruction, but also promote bone repair.
AUTOIMMUNITY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Eijiro Jimi, Hiroaki Honda, Ichiro Nakamura
Summary: p130Cas acts as an adapter protein and serves as a mechanosensor, playing important roles in cell functions and sensing mechanical stress. It is involved in bone formation, osteoclast function, and bone invasion by cancer cells. p130Cas may be a potential therapeutic target for bone diseases and cancer bone invasion.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: This article reviews the recent advances in understanding the molecular mechanism of skeletal-neural interactions in bone homeostasis, with a focus on the functions of axon guidance molecules in the establishment and maintenance of the skeletal system.
Review
Biochemistry & Molecular Biology
Hanxuan Li, Zhousheng Xiao, L. Darryl Quarles, Wei Li
Summary: Osteoporosis is a pathological condition characterized by a loss of bone mass due to an imbalance in bone remodeling. Current treatments include anti-resorptive agents and anabolic drugs, but severe side effects and loss of efficacy may limit long term usage. Sequential and combinational use of current drugs, as well as development of novel drugs against new targets, offer alternative approaches for osteoporosis treatment.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Gemma Marcucci, Vladana Domazetovic, Chiara Nediani, Jessica Ruzzolini, Claudio Favre, Maria Luisa Brandi
Summary: This review provides a detailed report on the cellular and molecular mechanisms involved in bone remodeling, specifically in relation to oxidative stress, inflammatory factors, and estrogen deficiency. Oxidative stress is a key factor in the development of osteoporosis, leading to osteocyte apoptosis and impaired bone remodeling and resorption. Recent studies have shown that natural antioxidants found in the diet can effectively prevent and reduce the negative effects of oxidative stress on bone health. These antioxidants target osteocytes and their molecular factors, promoting bone regeneration and preventing bone loss. This suggests that incorporating antioxidants into therapeutic approaches may improve the prevention and treatment of osteoporosis and related bone diseases.
Letter
Cell & Tissue Engineering
Carla Palumbo, Marzia Ferretti
Summary: This article provides a commentary on the manuscript by O. Krasnova and I. Neganova titled "Assembling the Puzzle Pieces: Insights for in Vitro Bone Remodeling." It highlights the significance of in vivo models in validating in vitro bone remodeling systems.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Supriya Jagga, Ashish Ranjan Sharma, Yeon Hee Lee, Ju-Suk Nam, Sang-Soo Lee
Summary: The study found that Ti particles can activate the NF kappa B signaling pathway and induce COX-2 and inflammatory cytokines in FLSs, ultimately promoting osteoclast formation. Additionally, conditioned medium collected from Ti particle-stimulated FLSs contains factors that can suppress markers of osteogenesis in osteoprogenitors, affecting the WNT and BMP signaling pathways and hindering osteoblastic activity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Beth S. Lee, Cynthia Murray, Jie Liu, Minji Kim, Min Sik Hwang, Tina Yueh, Myrna Mansour, Sana Qamar, Gunjan Agarwal, Do-Gyoon Kim
Summary: The results of the experiments show that MYO9B plays a crucial role in the mechanical stress-induced responses of bone cells in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Giacomina Brunetti, Gabriele D'Amato, Stefania De Santis, Maria Grano, Maria Felicia Faienza
Summary: Bone loss associated with T1DM can begin in childhood, leading to lower bone mass and increased risk of osteoporosis. The mechanisms underlying diabetic bone fragility, including the effects of hyperglycemia and insulin deficiency, are not yet fully understood.
WORLD JOURNAL OF DIABETES
(2021)
Article
Pharmacology & Pharmacy
Toshihiro Tsuruda, Taro Funamoto, Nobuyuki Udagawa, Syuji Kurogi, Yuko Nakamichi, Masanori Koide, Etsuo Chosa, Yujiro Asada, Kazuo Kitamura
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Toshiaki Ara, Masanori Koide, Hiroyuki Kitamura, Norio Sogawa
Review
Biochemistry & Molecular Biology
Kazuhiro Maeda, Yasuhiro Kobayashi, Masanori Koide, Shunsuke Uehara, Masanori Okamoto, Akihiro Ishihara, Tomohiro Kayama, Mitsuru Saito, Keishi Marumo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Masanori Koide, Teruhito Yamashita, Kohei Murakami, Shunsuke Uehara, Keigo Nakamura, Midori Nakamura, Mai Matsushita, Toshiaki Ara, Hisataka Yasuda, Josef M. Penninger, Naoyuki Takahashi, Nobuyuki Udagawa, Yasuhiro Kobayashi
SCIENTIFIC REPORTS
(2020)
Review
Endocrinology & Metabolism
Nobuyuki Udagawa, Masanori Koide, Midori Nakamura, Yuko Nakamichi, Teruhito Yamashita, Shunsuke Uehara, Yasuhiro Kobayashi, Yuriko Furuya, Hisataka Yasuda, Chie Fukuda, Eisuke Tsuda
Summary: Osteoclasts and osteoblasts play essential roles in bone remodeling, with the regulation of RANKL and OPG expression being a key mechanism. The balance between these factors is crucial for maintaining bone density and preventing bone loss.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Immunology
Aiko Ono-Ohmachi, Satoki Yamada, Satoru Uno, Masato Tamai, Kohei Soga, Shotaro Nakamura, Nobuyuki Udagawa, Yuko Nakamichi, Masanori Koide, Yoshikazu Morita, Tomohiro Takano, Takumi Itoh, Shigeru Kakuta, Chikao Morimoto, Shuji Matsuoka, Yoichiro Iwakura, Michio Tomura, Hiroshi Kiyono, Satoshi Hachimura, Haruyo Nakajima-Adachi
Summary: This study highlights the specific inflammatory relationship between MLNs and bone in food-allergic enteropathy, mediated by Th2-dominant-OVA-specific T cells and IL-4 production. Inhibition of IL-4 can reduce bone loss in EW-fed mice.
MUCOSAL IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Eisuke Tsuda, Chie Fukuda, Akiko Okada, Tsuyoshi Karibe, Yoshiharu Hiruma, Nana Takagi, Yoshitaka Isumi, Tomomaya Yamamoto, Tomoka Hasegawa, Shunsuke Uehara, Masanori Koide, Nobuyuki Udagawa, Norio Amizuka, Seiichiro Kumakura
Summary: It has been established that Siglec-15 plays a role in osteoclast differentiation and/or function, and therapies targeting Siglec-15 can potentially treat bone diseases like osteoporosis. Researchers have produced a rat monoclonal anti-Siglec-15 antibody (32A1) and a humanized monoclonal anti-Siglec-15 antibody (DS-1501a) derived from 32A1. Studies have shown that DS-1501a specifically binds to Siglec-15 and effectively inhibits osteoclast differentiation. In animal models, DS-1501a has demonstrated the ability to inhibit bone resorption markers and maintain bone mineral density, making it a promising candidate for osteoporosis treatment.
Article
Endocrinology & Metabolism
Shunsuke Uehara, Hideyuki Mukai, Teruhito Yamashita, Masanori Koide, Kohei Murakami, Nobuyuki Udagawa, Yasuhiro Kobayashi
Summary: The study suggests Pkn3 as a potential therapeutic target for treating bone loss. The p38 MAPK inhibitor SB202190 inhibits osteoclast function by suppressing the formation of resorption pits and actin rings. SB202190 also attenuates bone loss induced by ovariectomy.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Rina Iwamoto, Masanori Koide, Nobuyuki Udagawa, Yasuhiro Kobayashi
Summary: Sclerostin inhibits bone formation by suppressing the Wnt/β-catenin signaling pathway and plays a crucial role in maintaining bone mass. The expression of sclerostin is regulated by various factors, which in turn govern bone metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita-Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, Nobuyuki Udagawa, Johji Kato, Kazuo Kitamura
Summary: This study found that osteoprotegerin protects against aortic rupture and dissection in Ang II-induced hypertension by inhibiting receptor activator of nuclear factor-kappa B ligand activity and periostin expression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Masanori Koide, Teruhito Yamashita, Keigo Nakamura, Hisataka Yasuda, Nobuyuki Udagawa, Yasuhiro Kobayashi
Summary: This study found that approximately two-thirds of bone formation is remodeling-based in Sost-deficient mice, while remodeling-based bone formation accounts for most of the bone formation in Sost(+/-) mice. Anti-RANKL antibody may be useful for detecting modeling-based bone formation on trabecular bone.
Meeting Abstract
Endocrinology & Metabolism
Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Shunsuke Uehara, Naoyuki Takahashi, Nobuyuki Udagawa, Kohei Murakami, Hisataka Yasuda
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Meeting Abstract
Endocrinology & Metabolism
Nobuyuki Udagawa, Masanori Koide, Shunsuke Uehara, Atsushi Arai, Toshihide Mizoguchi, Teruhito Yamashita, Midori Nakamura, Yasuhiro Kobayashi, Naoyuki Takahashi, Seiichiro Kumakura, Chie Fukuda, Eisuke Tsuda
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Nobuyuki Udagawa, Shunsuke Uehara, Masanori Koide, Atsushi Arai, Toshihide Mizoguchi, Midori Nakamura, Yasuhiro Kobayashi, Naoyuki Takahashi, Chie Fukuda, Eisuke Tsuda
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)