Wnt signaling and cellular metabolism in osteoblasts

Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse

(2016) Weiwei Sun et al.   BONE

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

(2016) Steve Stegen et al.   Cell Metabolism

Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation

(2016) Courtney M. Karner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of diabetes mellitus-induced bone fragility

(2016) Nicola Napoli et al.   Nature Reviews Endocrinology

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

(2015) Jianwen Wei et al.   CELL

PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling

(2015) Emel Esen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights

(2015) Beata Lecka-Czernik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice

(2015) Jianquan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast

(2015) Julie L. Frey et al.   MOLECULAR AND CELLULAR BIOLOGY

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

(2015) Courtney R Green et al.   Nature Chemical Biology

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway

(2015) Bin Huang et al.   PLoS Genetics

mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts

(2015) Jianquan Chen et al.   PLoS One

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

(2014) Nobuaki Shiraki et al.   Cell Metabolism

Bioenergetics During Calvarial Osteoblast Differentiation Reflect Strain Differences in Bone Mass

(2014) Anyonya R. Guntur et al.   ENDOCRINOLOGY

The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations

(2014) Kyu Sang Joeng et al.   HUMAN MOLECULAR GENETICS

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling

(2014) Courtney M. Karner et al.   JOURNAL OF CLINICAL INVESTIGATION

Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis

(2014) R. C. Riddle et al.   MOLECULAR AND CELLULAR BIOLOGY

Up-regulation of glycolytic metabolism is required for HIF1 -driven bone formation

(2014) J. N. Regan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNT7B Promotes Bone Formation in part through mTORC1

(2014) Jianquan Chen et al.   PLoS Genetics

WNT signaling in bone development and homeostasis

(2014) Zhendong Zhong et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Aerobic Glycolysis in Osteoblasts

(2014) Emel Esen et al.   Current Osteoporosis Reports

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

(2013) Emel Esen et al.   Cell Metabolism

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

(2013) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Mutations in WNT1 are a cause of osteogenesis imperfecta

(2013) Somayyeh Fahiminiya et al.   JOURNAL OF MEDICAL GENETICS

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

(2013) Christine M. Laine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition

(2013) Ryan C. Riddle et al.   PLoS One

A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice

(2013) Kevin A. Maupin et al.   Bone Research

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development

(2012) Renée van Amerongen et al.   DEVELOPMENTAL BIOLOGY

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development

(2012) Takamitsu Maruyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice

(2012) Jianquan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Wntless functions in mature osteoblasts to regulate bone mass

(2012) Z. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

(2012) Hou-Feng Zheng et al.   PLoS Genetics

Absence of Glutamine Supplementation Prevents Differentiation of Murine Calvarial Osteoblasts to a Mineralizing Phenotype

(2011) Philip M. Brown et al.   CALCIFIED TISSUE INTERNATIONAL

Control of bone formation by the serpentine receptor Frizzled-9

(2011) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Negative regulation of osteoblastogenesis through downregulation of runt-related transcription factor-2 in osteoblastic MC3T3-E1 cells with stable overexpression of the cystine/glutamate antiporter xCT subunit

(2011) Kyosuke Uno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Negative Correlation Between Expression Profiles of Runt-Related Transcription Factor-2 and Cystine/Glutamate Antiporter xCT Subunit in Ovariectomized Mouse Bone

(2011) Kyosuke Uno et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

(2010) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of parathyroid hormone on amino acid transport by cultured neonatal mouse calvarial bone cells

(2010) John A. Yee   JOURNAL OF BONE AND MINERAL RESEARCH

Growth of rat osteoblast-like cells in a lipid-enriched culture medium and regulation of function by parathyroid hormone and 1,25-dihydroxyvitamin D

(2010) Bayard D. Catherwood et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ontogenesis of ultrastructural features during osteogenic differentiation in diffusion chamber cultures of marrow cells

(2010) L. Passi-Even et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells

(2010) Mika Takarada-Iemata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I

(2010) E. Zoidis et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Genetic Control of Bone Formation

(2009) Gerard Karsenty et al.   Annual Review of Cell and Developmental Biology

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation

(2009) Florian Witte et al.   GENE EXPRESSION PATTERNS

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

(2009) Jian Wang et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function

(2008) Andreas Niemeier et al.   BONE

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis

(2008) Joyce B. J. van Meurs   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

(2008) JB Richards et al.   LANCET