Journal
BONE
Volume 110, Issue -, Pages 378-385Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2018.02.027
Keywords
Osteoporosis; Bone mineral density; Genome-wide association study; 20p12.1; 20q13.33
Categories
Funding
- National Natural Science Foundation of China [31571291, 31771417, 31501026, 81460223]
- Natural Science Foundation of Jiangsu Province of China [BK20150323]
- NIH [R01AR059781, P20GM109036, R01AR069055, R01MH104680, U19AG055373]
- Edward G. Schlieder Endowment
- undergraduate innovation program of Jiangsu Province [201610285040Z]
- project of the priority academic program development of Jiangsu higher education institutions
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]
- NHLBI Contract [N02-HL-64278]
- NIA Division of Geriatrics and Clinical Gerontology
- parent grant, Genetic Determinants of Bone Fragility [P01-AG018397]
- NIH NIA
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In the present study, aiming to identify loci associated with osteoporosis, we conducted a joint association study of 2 independent genome-wide association meta-analyses of femoral neck and lumbar spine bone mineral densities (BMDs): 1) an in-house study of 6 samples involving 7484 subjects, and 2) the GEFOS-seq study of 7 samples involving 32,965 subjects. The in-house samples were imputed by the 1000 genomes project phase 3 reference panel. SNP-based association test was applied to 7,998,108 autosomal SNPs in each meta-analysis, and for each SNP the 2 association signals were then combined for joint analysis and for mutual replication. Combining the evidence from both studies, we identified 2 novel loci associated with BMDs at the genome-wide significance level (alpha = 5.0 x 10(-8)): 20p12.1 (rs73100693 p = 2.65 x 10(-8), closest gene MACROD2) and 20q13.33 (rs2380128 p = 3.44 x 10(-8), 088112). We also replicated 7 loci that were reported by two recent studies on heel and total body BMD. Our findings provide useful insights that enhance our understanding of bone development, osteoporosis and fracture pathogenesis. (C) 2018 Elsevier Inc. All rights reserved.
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