Gain‐of‐Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin‐Deficient Diabetes

Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function

(2020) Julie Lacombe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sclerostin Regulation, Microarchitecture, And Advanced Glycation End‐Products In The Bone Of Elderly Women With Type 2 Diabetes

(2020) Alessandra Piccoli et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties

(2019) Ann-Kristin Picke et al.   Endocrine Connections

Effect of Insulin Resistance on BMD and Fracture Risk in Older Adults

(2019) Nicola Napoli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lrp4 expression by adipocytes and osteoblasts differentially impacts sclerostin’s endocrine effects on body composition and glucose metabolism

(2019) Soohyun P. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk factors for fragility fractures in type 1 diabetes

(2019) Giulia Leanza et al.   BONE

Impaired Nociception in the DiabeticIns2+/AkitaMouse

(2018) Nisha Vastani et al.   DIABETES

MECHANISMS IN ENDOCRINOLOGY: Diabetes mellitus, a state of low bone turnover – a systematic review and meta-analysis

(2017) Katrine Hygum et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2 Akita+/− mouse model of type 1 diabetes

(2017) Constanze C. Maresch et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

(2017) Soohyun P. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical bone turnover markers in diabetes mellitus — A systematic review

(2016) Jakob Starup-Linde et al.   BONE

Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes

(2016) Deborah E. Sellmeyer et al.   DIABETES

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the K ATP channel

(2016) Maria S. Remedi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mechanisms of diabetes mellitus-induced bone fragility

(2016) Nicola Napoli et al.   Nature Reviews Endocrinology

Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice

(2016) Mishaela R. Rubin et al.   PLoS One

Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells

(2015) Ken-ichiro Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Type 1 Diabetes Is Associated With an Increased Risk of Fracture Across the Life Span: A Population-Based Cohort Study Using The Health Improvement Network (THIN)

(2015) David R. Weber et al.   DIABETES CARE

High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo

(2015) Paul J Niziolek et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nonenzymatic Glycation and Degree of Mineralization Are Higher in Bone From Fractured Patients With Type 1 Diabetes Mellitus

(2015) Delphine Farlay et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

(2014) Jianwen Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

(2014) Michael R. McClung et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

(2014) Nicola Napoli et al.   International Journal of Endocrinology

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

Both spontaneousIns2+/−and streptozotocin-induced type I diabetes cause bone loss in young mice

(2012) Lindsay M. Coe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sclerostin Levels Associated with Inhibition of the Wnt/β-Catenin Signaling and Reduced Bone Turnover in Type 2 Diabetes Mellitus

(2012) Agostino Gaudio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes

(2012) Luigi Gennari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

(2011) Paul J. Niziolek et al.   BONE

Trabecular bone histomorphometry in humans with Type 1 Diabetes Mellitus

(2011) Laura A.G. Armas et al.   BONE

Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes

(2011) Ann V. Schwartz   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis

(2011) Susan K Grimston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circulating Levels of Sclerostin Are Increased in Patients with Type 2 Diabetes Mellitus

(2011) Antonia García-Martín et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

An ELISA-based method to quantify osteocalcin carboxylation in mice

(2010) Mathieu Ferron et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Alterations of the Wnt/β-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice

(2010) S. Portal-Núñez et al.   FEBS LETTERS

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms

(2010) A. Di Benedetto et al.   JOURNAL OF CELL SCIENCE

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH