Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

(2022) Christopher Hoyle et al.   IMMUNOLOGY

4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway

(2022) Qingchen Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Four-Octyl Itaconate Protects Chondrocytes against H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

(2022) Peng Zhang et al.   Oxidative Medicine and Cellular Longevity

Melatonin: A novel candidate for the treatment of osteoarthritis

(2022) Yijian Zhang et al.   AGEING RESEARCH REVIEWS

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages

(2022) Libin Ni et al.   BIOCHEMICAL PHARMACOLOGY

Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases

(2022) Min-Ji Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation

(2022) So-Ra Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury

(2022) Ruijing Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo

(2022) Shan-Chi Liu et al.   Cell Death & Disease

Cell-free fat extract attenuates osteoarthritis via chondrocytes regeneration and macrophages immunomodulation

(2022) Zhuoxuan Jia et al.   Stem Cell Research & Therapy

The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis

(2022) Maurizio Cutolo et al.   Frontiers in Immunology

Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders

(2022) Stefan W. Ryter   Antioxidants

Effect of Pulsed Low-Intensity Ultrasonography on Symptom Relief and Tibiofemoral Articular Cartilage Thickness Among Veterans Affairs Enrollees With Knee Osteoarthritis

(2022) Allen D. Sawitzke et al.   JAMA Network Open

Pulsed-Ultrasound Irradiation Induces the Production of Itaconate and Attenuates Inflammatory Responses in Macrophages

(2022) Atomu Yamaguchi et al.   Journal of Inflammation Research

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

(2022) Mateja Sirše   Life-Basel

Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy

(2022) Longfa Kou et al.   JOURNAL OF CONTROLLED RELEASE

Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32

(2022) Jianbin Yin et al.   Cell Death & Disease

Granulocyte macrophage colony-stimulating factor has come of age: from a vaccine adjuvant to antiviral immunotherapy

(2021) Maria Petrina et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Quercetin suppresses apoptosis of chondrocytes induced by IL‑1β via inactivation of p38 MAPK signaling pathway

(2021) Xiang-Peng Wang et al.   Experimental and Therapeutic Medicine

Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis

(2021) Yohei Sanada et al.   Antioxidants

A Comparative Review of Autologous Conditioned Serum and Autologous Protein Solution for Treatment of Osteoarthritis in Horses

(2021) Livia Camargo Garbin et al.   Frontiers in Veterinary Science

The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment

(2021) Ana Patrícia Cardoso et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Maresin 1 alleviates the inflammatory response, reduces oxidative stress and protects against cardiac injury in LPS-induced mice

(2021) Dan Li et al.   LIFE SCIENCES

Polarized cytokine release from airway epithelium differentially influences macrophage phenotype

(2021) W. Skronska-Wasek et al.   MOLECULAR IMMUNOLOGY

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

(2021) Zhongyang Lv et al.   Cell Death & Disease

Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages

(2021) Stephanie B. Wall et al.   Antioxidants

Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling

(2021) Peng Wang et al.   iScience

Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes

(2021) Maedeh Arabpour et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Targeted Nanosystem for Detection of Inflammatory Diseases via Fluorescent/Optoacoustic Imaging and Therapy via Modulating Nrf2/NF‐κB Pathways

(2021) Juan Ouyang et al.   Small

Quercetin‐Loaded Ceria Nanocomposite Potentiate Dual‐Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation

(2021) Yu Wang et al.   Small

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

(2021) Noymar Luque-Campos et al.   Frontiers in Immunology

5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression

(2021) Su-Lim Kim et al.   Antioxidants

Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling

(2021) Wenjun Li et al.   Journal of Inflammation Research

The role of the electron transport chain in immunity

(2021) Maureen Yin et al.   FASEB JOURNAL

The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway

(2021) Xing Luo et al.   LIFE SCIENCES

NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB

(2021) Hongchu Bao et al.   MEDIATORS OF INFLAMMATION

Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects

(2021) Seyed Hossein Shahcheraghi et al.   MOLECULES

Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization

(2021) Hongyan Lu et al.   Oxidative Medicine and Cellular Longevity

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

(2021) Jessica B. Spinelli et al.   SCIENCE

Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance

(2021) Cheng-Fang Tsai et al.   Nutrients

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

(2021) Hongjuan Ning et al.   Stem Cell Research & Therapy

Macrophage Polarization and Its Role in Liver Disease

(2021) Cheng Wang et al.   Frontiers in Immunology

Reactive Oxygen Species in Macrophages: Sources and Targets

(2021) Marcella Canton et al.   Frontiers in Immunology

Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?

(2021) Patrick Haubruck et al.   Frontiers in Immunology

NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling

(2021) Susana López-López et al.   Frontiers in Immunology

Resolvin D1 ‐loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of Osteoarthritis

(2021) Ameya A. Dravid et al.   Bioengineering & Translational Medicine

Joint synovial macrophages as a potential target for intra-articular treatment of osteoarthritis-related pain

(2021) D. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

The acetyltransferase p300 regulates NRF2 stability and localization

(2020) Athina Ganner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation

(2020) Chao Jiang et al.   CELL STRESS & CHAPERONES

The role of JAK/STAT signaling pathway and its inhibitors in diseases

(2020) Ping Xin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases

(2020) William T. Festuccia   MOLECULAR NUTRITION & FOOD RESEARCH

Macrophages regulate the progression of osteoarthritis

(2020) H. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways

(2020) Neety Sahu et al.   Stem Cell Research & Therapy

Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade

(2020) Md Badrul Alam et al.   Biomolecules

Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound

(2020) Chung-Hwan Chen et al.   International Journal of Nanomedicine

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Dual delivery of stem cells and insulin-like growth Factor-1 in coacervate-embedded composite hydrogels for enhanced cartilage regeneration in osteochondral defects

(2020) Hyeran Cho et al.   JOURNAL OF CONTROLLED RELEASE

Redox Regulation of STAT1 and STAT3 Signaling

(2020) Elena Butturini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages

(2020) Susana López-López et al.   Scientific Reports

Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis

(2020) Chih-Kang Chiang et al.   Scientific Reports

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

(2020) Jiangmei Wang et al.   Stem Cell Research & Therapy

Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

(2020) Jonathan Muri et al.   Redox Biology

SOD1 suppresses pro-inflammatory immune responses by protecting against oxidative stress in colitis

(2020) Jiyoung Hwang et al.   Redox Biology

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Adipose mesenchymal stem cell-derived antioxidative extracellular vesicles exhibit anti-oxidative stress and immunomodulatory effects under PM2.5 exposure

(2020) Yongheng Gao et al.   TOXICOLOGY

Melatonin in macrophage biology: Current understanding and future perspectives

(2019) Yaoyao Xia et al.   JOURNAL OF PINEAL RESEARCH

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

(2019) Jinwei Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hippo signaling controls NLRP 3 Activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury

(2019) Changyong Li et al.   HEPATOLOGY

Metabolic immunomodulation of macrophage functional plasticity in nonhealing wounds

(2019) Catherine B. Anders et al.   CURRENT OPINION IN INFECTIOUS DISEASES

TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages

(2019) Kritika Sudan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects

(2019) Qirui Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway

(2019) Xinyu Lin et al.   PLoS One

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88

(2019) Jing Gong et al.   BMC Complementary and Alternative Medicine

Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells via Suppressing AP-1 Activity and Activation of Nrf2/ HO-1 Pathway

(2019) Xue-Juan Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

(2019) Tao Yu et al.   Nature Communications

Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity

(2019) Da Hye Kwon et al.   Antioxidants

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

(2019) Sergio Rius-Pérez et al.   ANTIOXIDANTS & REDOX SIGNALING

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin Promotes Diabetic Wound Healing via Switching Macrophages From M1 to M2 Polarization

(2019) Jia Fu et al.   JOURNAL OF SURGICAL RESEARCH

Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis

(2019) Changsun Kang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization

(2019) G. Barreto et al.   OSTEOARTHRITIS AND CARTILAGE

Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and suggests anti-inflammatory mechanism of action

(2019) Amanda M. Hamilton et al.   PLoS One

Intrarenal Transplantation of Hypoxic Preconditioned Mesenchymal Stem Cells Improves Glomerulonephritis through Anti-Oxidation, Anti-ER Stress, Anti-Inflammation, Anti-Apoptosis, and Anti-Autophagy

(2019) Hao-Hsiang Chang et al.   Antioxidants

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

(2018) Si-tong Li et al.   ACTA PHARMACOLOGICA SINICA

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats

(2018) Linan Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway

(2018) Sun Young Park et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The Pharmacokinetics of Fumaric Acid Esters Reveal Their In Vivo Effects

(2018) Ulrich Mrowietz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Peripheral Mechanisms Contributing to Osteoarthritis Pain

(2018) Delfien Syx et al.   Current Rheumatology Reports

NF-kappaB: Two Sides of the Same Coin

(2018) Bruno Pires et al.   Genes

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

(2018) Feilong Wang et al.   EBioMedicine

Therapeutic potential of hyaluronic acid/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in�vitro evaluation in chondrocytes

(2018) Jian Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Intra-Articular Delivery of Quercetin Using Thermosensitive Hydrogel Attenuate Cartilage Degradation in an Osteoarthritis Rat Model

(2018) Sze-Wing Mok et al.   Cartilage

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

(2018) Pieter Ruytinx et al.   Frontiers in Immunology

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

(2018) Tiantian Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

M2b macrophage polarization and its roles in diseases

(2018) Le-xun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization

(2017) Woo-Jin Yi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells

(2017) Lih-Geeng Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages

(2017) Xu-Xin Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeting and modulating infarct macrophages with hemin formulated in designed lipid-based particles improves cardiac remodeling and function

(2017) Tamar Ben-Mordechai et al.   JOURNAL OF CONTROLLED RELEASE

Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules

(2017) T.V. Stabler et al.   OSTEOARTHRITIS AND CARTILAGE

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

Future therapeutic targets in rheumatoid arthritis?

(2017) Tommy Tsang Cheung et al.   Seminars in Immunopathology

The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche

(2017) Amer Youssef et al.   Stem Cells International

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

(2017) Marina Diotallevi et al.   Frontiers in Immunology

Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway

(2017) Ruiling Liu et al.   PLoS One

Carbocisteine attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways

(2016) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

(2016) Sunmin Park et al.   Genes and Nutrition

IGF-I induces adipose derived mesenchymal cell chondrogenic differentiation in vitro and enhances chondrogenesis in vivo

(2016) Quan Zhou et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

NADPH Oxidases Are Essential for Macrophage Differentiation

(2016) Qing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage

(2016) P. Behrendt et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro , but not inhibited directly by anti-inflammatory (M2) macrophages

(2016) L. Utomo et al.   OSTEOARTHRITIS AND CARTILAGE

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages

(2016) Emeric Limagne et al.   Nutrients

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

(2016) Sunmin Park et al.   Genes and Nutrition

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

(2015) C. I. Caescu et al.   BLOOD

Quercetin: A flavonol with multifaceted therapeutic applications?

(2015) Gabriele D'Andrea   FITOTERAPIA

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

(2015) Pengjun Xiang et al.   INFLAMMATION RESEARCH

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

(2015) Hyun Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Arthritic and non-arthritic synovial fluids modulate IL10 and IL1RA gene expression in differentially activated primary human monocytes

(2015) S. Lopa et al.   OSTEOARTHRITIS AND CARTILAGE

STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3

(2015) Hun Sik Kim et al.   Scientific Reports

Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis

(2015) Guohui Yang   MEDICAL SCIENCE MONITOR

Regulation of Notch 1 signaling in THP-1 cells enhances M2 macrophage differentiation

(2014) Reetu D. Singla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Heme oxygenase-1 and anti-inflammatory M2 macrophages

(2014) Yuji Naito et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dimethyl fumarate protection against collagen II degradation

(2014) Ye Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin

(2014) Sarandeep S. S. Boyanapalli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

(2014) Lindsey E. Padgett et al.   DIABETES

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of a TGF- -Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid-Mediated Surface Expression of TGF-  Receptor II

(2014) A. Gratchev et al.   JOURNAL OF IMMUNOLOGY

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

(2014) N. Fahy et al.   OSTEOARTHRITIS AND CARTILAGE

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Reprograming in Macrophage Polarization

(2014) Silvia Galván-Peña et al.   Frontiers in Immunology

Redox Control of Inflammation in Macrophages

(2013) Bernhard Brüne et al.   ANTIOXIDANTS & REDOX SIGNALING

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

(2013) Maria Ester Bernardo et al.   Cell Stem Cell

BTB and CNC Homolog 1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice

(2013) Akihito Harusato et al.   INFLAMMATORY BOWEL DISEASES

Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

(2013) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

CCL18 Activates Fibroblast-like Synoviocytes in Patients with Rheumatoid Arthritis

(2013) A. TAKAYASU et al.   JOURNAL OF RHEUMATOLOGY

The epidemiology and impact of pain in osteoarthritis

(2013) T. Neogi   OSTEOARTHRITIS AND CARTILAGE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation

(2013) Yu-Jin Hwang et al.   Scientific Reports

Mesenchymal Stem Cells in Tissue Repair

(2013) Amy M. DiMarino et al.   Frontiers in Immunology

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

(2012) Ashish Bhattacharjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of macrophage activation and programming in immunity

(2012) Guangwei Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumor associated macrophages and neutrophils in tumor progression

(2012) Maria R. Galdiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Acanthopanax senticosus has a heme oxygenase-1 signaling-dependent effect on Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages

(2012) Hye Soo Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization

(2011) Palash Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF Mediates the Sustained Activation of Nrf2 in Human Monocytes

(2011) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway

(2011) Azadeh Montaseri et al.   PLoS One

Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-κB activation

(2010) Pu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1

(2010) Takuya Miyazaki et al.   CANCER SCIENCE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment

(2010) I. Gurkan et al.   OSTEOARTHRITIS AND CARTILAGE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Notch1 upregulates LPS-induced macrophage activation by increasing NF-κB activity

(2009) Eva Monsalve et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: Roles of the MAP kinases ERK1/2and JNK

(2009) D. Goven et al.   FEBS LETTERS

The role of c-Jun phosphorylation in EpRE activation of phase II genes

(2009) Smadar Levy et al.   FREE RADICAL BIOLOGY AND MEDICINE

The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells

(2009) Palash Mandal et al.   HEPATOLOGY

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

(2009) Xiaoyu Hu et al.   IMMUNOLOGICAL REVIEWS

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Heme Oxygenase-1 Contributes to an Alternative Macrophage Activation Profile Induced by Apoptotic Cell Supernatants

(2009) Nicole Weis et al.   MOLECULAR BIOLOGY OF THE CELL

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Platelet-Derived Growth Factor BB Mediates the Tropism of Human Mesenchymal Stem Cells for Malignant Gliomas

(2009) Nobuhiro Hata et al.   NEUROSURGERY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-α in human articular chondrocytes in vitro

(2008) R.D. Müller et al.   CYTOKINE

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

(2008) M. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark