Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis

Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation

(2020) Chao Jiang et al.   CELL STRESS & CHAPERONES

Scutellarin Attenuates the IL-1β-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression

(2020) Zucheng Luo et al.   Frontiers in Pharmacology

Nomilin targets the Keap1‐Nrf2 signalling and ameliorates the development of osteoarthritis

(2020) Xing‐He Xue et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis

(2020) Keita Nagira et al.   Scientific Reports

N-acetylcysteine Provides Cytoprotection in Murine Oligodendrocytes through Heme Oxygenase-1 Activity

(2020) Jie Zhou et al.   Biomedicines

S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway

(2020) Zhenxuan Shao et al.   Aging-US

A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H2O2, and produce large amounts CO for a highly efficient treatment of osteoarthritis

(2020) Guangzhen Yang et al.   BIOMATERIALS

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

(2020) Zijian Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hyperoside ameliorates the progression of osteoarthritis: an in vitro and in vivo study

(2020) Kai Sun et al.   PHYTOMEDICINE

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

(2020) Philip R. Coryell et al.   Nature Reviews Rheumatology

The protective effect of sinapic acid in osteoarthritis: In vitro and in vivo studies

(2019) Xiaobin Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes

(2019) Seong Jin et al.   MOLECULES

RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

(2019) Young-Ok Son et al.   Nature Communications

Alleviation of Cartilage Destruction by Sinapic Acid in Experimental Osteoarthritis

(2019) Dawei Cai et al.   Biomed Research International

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

(2019) Song Ho Chang et al.   Nature Communications

KLF2 regulates eNOS uncoupling via Nrf2/HO-1 in endothelial cells under hypoxia and reoxygenation

(2019) WeiDang Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

(2019) Zhenhan Deng et al.   BIOSCIENCE REPORTS

Expression and function of miR‑155 in rat synovial fibroblast model of rheumatoid arthritis

(2019) Hewei Li et al.   Experimental and Therapeutic Medicine

Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation

(2019) Feng-Cheng Liu et al.   Nutrients

7,8‑Dihydroxyflavone activates Nrf2/HO‑1 signaling pathways and protects against osteoarthritis

(2019) Dawei Cai et al.   Experimental and Therapeutic Medicine

Dihydroartemisinin derivative DC32 inhibits inflammatory response in osteoarthritic synovium through regulating Nrf2/NF-κB pathway

(2019) Ya-Nan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

(2019) Pallab Shaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation

(2019) Chiang-Wen Lee et al.   MOLECULAR IMMUNOLOGY

Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

(2019) Olivier Malaise et al.   Aging-US

Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis

(2019) Kai Sun et al.   Aging-US

Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways

(2019) Yifan Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation of Nrf2/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis

(2019) Xiangxiang Pan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo

(2019) Xiang Gao et al.   Oxidative Medicine and Cellular Longevity

Heme oxygenase-1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung

(2019) Sally H. Vitali et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Moracin attenuates LPS-induced inflammation in nucleus pulposus cells via Nrf2/HO-1 and NF-κB/TGF-β pathway

(2019) Ronghe Gu et al.   BIOSCIENCE REPORTS

Relevance of Nrf2 and heme oxygenase-1 in articular diseases

(2019) Maria José Alcaraz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 as a therapeutic target for rheumatic diseases

(2018) María Luisa Ferrándiz et al.   BIOCHEMICAL PHARMACOLOGY

Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes

(2018) Hiroyuki Ishitobi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis

(2018) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gene Delivery to Joints by Intra-Articular Injection

(2018) Christopher H. Evans et al.   HUMAN GENE THERAPY

Sauchinone inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2/HO-1 and NF-κB pathways

(2018) Dengying Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Senescent cells and osteoarthritis: a painful connection

(2018) Ok Hee Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid Heme Oxygenase-1 Regulates the Acute Inflammatory Response to Zymosan in the Mouse Air Pouch

(2018) Rita Brines et al.   Oxidative Medicine and Cellular Longevity

Development and characterization of various osteoarthritis models for tissue engineering

(2018) Ji Eun Kim et al.   PLoS One

Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis

(2018) Gang Zheng et al.   Food & Function

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

(2018) Claire Vinatier et al.   Frontiers in Physiology

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

(2018) Tiantian Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inhibition of protein kinase CK2 facilitates cellular senescence by inhibiting the expression of HO-1 in articular chondrocytes

(2018) Kang Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Induction of Krüppel-like factor 2 reduces K/BxN serum-induced arthritis

(2018) Manjusri Das et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes

(2017) Nazir M. Khan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Inflammatory Effects of Licochalcone A on IL-1β-Stimulated Human Osteoarthritis Chondrocytes

(2017) Tao Jia et al.   INFLAMMATION

Role of microRNA-155 in rheumatoid arthritis

(2017) Lin-Chong Su et al.   International Journal of Rheumatic Diseases

The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis

(2017) Carlos Vaamonde-Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis

(2017) Jamilah Abusarah et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review

(2017) Jonathan Kershaw et al.   JOURNAL OF MEDICINAL FOOD

Chemokines and inflammation in osteoarthritis: Insights from patients and animal models

(2017) Carla R. Scanzello   JOURNAL OF ORTHOPAEDIC RESEARCH

Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model

(2017) Yong-Jian Wang et al.   LIFE SCIENCES

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells

(2017) Shohei Murakami et al.   MOLECULAR AND CELLULAR BIOLOGY

Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis

(2017) Jie Sun et al.   MOLECULAR IMMUNOLOGY

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

(2017) Yulong Wei et al.   Molecular Medicine Reports

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The STR/ort mouse model of spontaneous osteoarthritis – an update

(2017) K.A. Staines et al.   OSTEOARTHRITIS AND CARTILAGE

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

(2017) Young-Ok Son et al.   Nature Communications

Piceatannol inhibits the IL-1β-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2

(2017) Qian Tang et al.   Food & Function

Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis

(2017) Shu-Jui Kuo et al.   PLoS One

ROS/oxidative stress signaling in osteoarthritis

(2016) Panagiotis Lepetsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

(2016) Hiroyasu Tabe et al.   CHEMICAL COMMUNICATIONS

Daily sesame oil supplement attenuates joint pain by inhibiting muscular oxidative stress in osteoarthritis rat model

(2016) Dur-Zong Hsu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins

(2016) S. D'Adamo et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

(2016) Stefan W. Ryter et al.   Translational Research

Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

(2016) Shulin Pan et al.   Oncotarget

The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity

(2016) Yusheng Li et al.   Journal of Orthopaedic Surgery and Research

Animal models of osteoarthritis: classification, update, and measurement of outcomes

(2016) Emmanuel L. Kuyinu et al.   Journal of Orthopaedic Surgery and Research

Roles of Nrf2 in cell proliferation and differentiation

(2015) Shohei Murakami et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α

(2015) Wuyin Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells

(2015) SUN-OH JEONG et al.   Molecular Medicine Reports

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1

(2015) Tsuyoshi Takada et al.   ARTHRITIS RESEARCH & THERAPY

Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

(2015) Masato Koike et al.   Scientific Reports

Reflecting on the global burden of musculoskeletal conditions: lessons learnt from the Global Burden of Disease 2010 Study and the next steps forward

(2014) Damian G Hoy et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia-Responsive MicroRNA-101 Promotes Angiogenesis via Heme Oxygenase-1/Vascular Endothelial Growth Factor Axis by Targeting Cullin 3

(2014) Ji-Hee Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme oxygenase-1 and anti-inflammatory M2 macrophages

(2014) Yuji Naito et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Induction of heme oxygenase-1 expression protects articular chondrocytes against cilostazol-induced cellular senescence

(2014) KANG MI KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Age Dependent Changes in Cartilage Matrix, Subchondral Bone Mass, and Estradiol Levels in Blood Serum, in Naturally Occurring Osteoarthritis in Guinea Pigs

(2014) Jin-Yin Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Signaling Function of Heme Oxygenase Proteins

(2013) Phyllis A. Dennery   ANTIOXIDANTS & REDOX SIGNALING

Sulforaphane Represses Matrix-Degrading Proteases and Protects Cartilage From Destruction In Vitro and In Vivo

(2013) Rose K. Davidson et al.   ARTHRITIS AND RHEUMATISM

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

(2013) Victoria Clérigues et al.   CLINICAL SCIENCE

Useful animal models for the research of osteoarthritis

(2013) Kalliopi Lampropoulou-Adamidou et al.   European Journal of Orthopaedic Surgery and Traumatology

Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes

(2013) Francis Rousset et al.   PLoS One

Heme oxygenase 1 attenuates interleukin-1β-induced cytosolic phospholipase A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator protein 1 activation in rheumatoid arthritis synovial fibroblasts

(2012) Pei-Ling Chi et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice

(2012) Ryo Ohta et al.   EUROPEAN SPINE JOURNAL

Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation

(2012) Miguel G. Salom et al.   KIDNEY INTERNATIONAL

In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice

(2012) Junghyun Kim et al.   KIDNEY INTERNATIONAL

Bone remodelling in osteoarthritis

(2012) David B. Burr et al.   Nature Reviews Rheumatology

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

Local gene delivery of heme oxygenase-1 by adeno-associated virus into osteoarthritic mouse joints exhibiting synovial oxidative stress

(2012) S. Kyostio-Moore et al.   OSTEOARTHRITIS AND CARTILAGE

Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription

(2012) Mathias Glehr et al.   PHYTOMEDICINE

Procyanidin B3 Prevents Articular Cartilage Degeneration and Heterotopic Cartilage Formation in a Mouse Surgical Osteoarthritis Model

(2012) Hailati Aini et al.   PLoS One

Heme Oxygenase-1 Regulates the Progression of K/BxN Serum Transfer Arthritis

(2012) Rita Brines et al.   PLoS One

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

(2012) Marc C. Hochberg et al.   ARTHRITIS CARE & RESEARCH

Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease

(2011) Nuria Maicas et al.   ANTIOXIDANTS & REDOX SIGNALING

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Bach1 regulates osteoclastogenesis in a mouse model via both heme oxygenase 1-dependent and heme oxygenase 1-independent pathways

(2011) Maasa Hama et al.   ARTHRITIS AND RHEUMATISM

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1

(2011) Pu Wang et al.   FASEB JOURNAL

Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells

(2011) Kati H. Pulkkinen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases

(2011) Yuji Naito et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Oxidative stress induces senescence in chondrocytes

(2011) Anita Brandl et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees

(2011) K.A. Payne et al.   OSTEOARTHRITIS AND CARTILAGE

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR/OrtCrlj mice by measuring the biomarkers for oxidative stress and type II collagen degradation/synthesis

(2011) TAIJI WATARI et al.   Experimental and Therapeutic Medicine

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

(2010) C. J. Wruck et al.   ANNALS OF THE RHEUMATIC DISEASES

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Bach1-dependent and -independent Regulation of Heme Oxygenase-1 in Keratinocytes

(2010) Shuko Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Heme Oxygenase-1 Protein Expression by miR-377 in Combination with miR-217

(2010) Joan D. Beckman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sp1 Regulates Chromatin Looping between an Intronic Enhancer and Distal Promoter of the Human Heme Oxygenase-1 Gene in Renal Cells

(2010) Jessy Deshane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCAAT/Enhancer-binding Protein β and NF-κB Mediate High Level Expression of Chemokine GenesCCL3andCCL4by Human Chondrocytes in Response to IL-1β

(2010) Zhiqi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

(2010) Haruhiko Siomi et al.   MOLECULAR CELL

Genetic epidemiology of hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis

(2010) Fei Zhu et al.   PLoS One

Haem oxygenase-1 down-regulates high mobility group box 1 and matrix metalloproteinases in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   RHEUMATOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins

(2009) Weihong Hou et al.   HEPATOLOGY

Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf2

(2009) S. Naidu et al.   JOURNAL OF IMMUNOLOGY

N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis

(2009) Shuji Nakagawa et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair

(2009) S. Panicker et al.   OSTEOARTHRITIS AND CARTILAGE

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

(2008) Joost O. Fledderus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative stress reaction in the meniscus of Bach 1 deficient mice: Potential prevention of meniscal degeneration

(2008) Satoshi Ochiai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis

(2007) C.M. Davies et al.   OSTEOARTHRITIS AND CARTILAGE